Gene Symbol | Htr6 |
Entrez Gene ID | 15565 |
Full Name | 5-hydroxytryptamine (serotonin) receptor 6 |
Synonyms | 5-HT6 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Htr6 cDNA ORF clone
Gene Symbol | Htr6 |
Entrez Gene ID | 15565 |
Full Name | 5-hydroxytryptamine (serotonin) receptor 6 |
Synonyms | 5-HT6 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_011250196.1 | XP_011248498.1 | 5-hydroxytryptamine receptor 6 isoform X1 |
NM_001377096.1 | NP_001364025.1 | 5-hydroxytryptamine receptor 6 |
XM_011250196.2 | XP_011248498.1 | 5-hydroxytryptamine receptor 6 isoform X1 |
NM_021358.2 | NP_067333.1 | 5-hydroxytryptamine receptor 6 |
Mus musculus (house mouse) | Htr6 | NP_067333.1 |
Rattus norvegicus (Norway rat) | Htr6 | NP_077341.1 |
Danio rerio (zebrafish) | LOC568269 | XP_696681.5 |
Bos taurus (cattle) | HTR6 | NP_001192646.1 |
Homo sapiens (human) | HTR6 | NP_000862.1 |
Pan troglodytes (chimpanzee) | HTR6 | NP_001029264.1 |
LOC716776 | XP_001107724.2 | |
Gallus gallus (chicken) | HTR6 | NP_001166911.1 |
Xenopus tropicalis (tropical clawed frog) | htr6 | XP_002942005.2 |
Canis lupus familiaris (dog) | HTR6 | XP_544528.4 |
Serotonin 5-HT6 receptors affect cognition in a mouse model of Alzheimer's disease by regulating cilia function.
Hu L, Wang B, Zhang Y
Alzheimer's research & therapy9(1)76(2017 Sep)
5-HT
Brodsky M, Lesiak AJ, Croicu A, Cohenca N, Sullivan JM, Neumaier JF
Brain research166010-19(2017 04)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
5-HT6/7 receptor antagonist ADN-1184 displays anxiolytic-like activity in animal models of anxiety which employed punished stimuli.
Title: ADN-1184, a monoaminergic ligand with 5-HT6/7 receptor antagonist action, exhibits activity in animal models of anxiety.
SNX14 is a dual endogenous negative regulator in 5-HT6R-mediated signaling pathway.
Title: SNX14 is a bifunctional negative regulator for neuronal 5-HT6 receptor signaling.
Constitutive expression of 5-HT6R controls pyramidal neuron migration through an agonist-independent mechanism that requires Cdk5 activity.
Title: The serotonin 6 receptor controls neuronal migration during corticogenesis via a ligand-independent Cdk5-dependent mechanism.
Knockdown of MAO-A expression in embryos induces high serotonin levels and abnormal brain development, which can be rescued by inactivation of serotonin receptor-6.
Title: Serotonin receptor 6 mediates defective brain development in monoamine oxidase A-deficient mouse embryos.
The following Htr6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Htr6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu12234 | |
Clone ID Related Accession (Same CDS sequence) | XM_011250196.1 , NM_001377096.1 , XM_011250196.2 , NM_021358.2 | |
Accession Version | NM_001377096.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1323bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-12 | |
Organism | Mus musculus(house mouse) | |
Product | 5-hydroxytryptamine receptor 6 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL805923.6. On Dec 13, 2019 this sequence version replaced XM_011250196.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7974084.501.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849378, SAMN00849379 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length. |
1 | ATGGTTCCAG AGCCCGGCCC TGTCAACAGT AGCACCCCAG CCTGGGGCCC CGGGCCACCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001364025.1 |
CDS | 707..2029 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001377096.1 |
1 | ATGGTTCCAG AGCCCGGCCC TGTCAACAGT AGCACCCCAG CCTGGGGCCC CGGGCCACCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu12234 | |
Clone ID Related Accession (Same CDS sequence) | XM_011250196.1 , NM_001377096.1 , XM_011250196.2 , NM_021358.2 | |
Accession Version | NM_021358.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1323bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | 5-hydroxytryptamine receptor 6 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL805923.6. On Nov 17, 2006 this sequence version replaced NM_021358.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC116653.1, AF134158.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849378, SAMN00849379 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGTTCCAG AGCCCGGCCC TGTCAACAGT AGCACCCCAG CCTGGGGCCC CGGGCCACCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_067333.1 |
CDS | 29..1351 |
Translation |
Target ORF information:
Target ORF information:
|
NM_021358.2 |
1 | ATGGTTCCAG AGCCCGGCCC TGTCAACAGT AGCACCCCAG CCTGGGGCCC CGGGCCACCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu12234 | |
Clone ID Related Accession (Same CDS sequence) | XM_011250196.1 , NM_001377096.1 , XM_011250196.2 , NM_021358.2 | |
Accession Version | XM_011250196.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1323bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-02-08 | |
Organism | Mus musculus(House mouse) | |
Product | 5-hydroxytryptamine receptor 6 isoform X1 | |
Comment |
1 | ATGGTTCCAG AGCCCGGCCC TGTCAACAGT AGCACCCCAG CCTGGGGCCC CGGGCCACCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011248498.1 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011250196.1 |
1 | ATGGTTCCAG AGCCCGGCCC TGTCAACAGT AGCACCCCAG CCTGGGGCCC CGGGCCACCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu12234 | |
Clone ID Related Accession (Same CDS sequence) | XM_011250196.1 , NM_001377096.1 , XM_011250196.2 , NM_021358.2 | |
Accession Version | XM_011250196.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1323bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | 5-hydroxytryptamine receptor 6 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000070.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011250196.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGTTCCAG AGCCCGGCCC TGTCAACAGT AGCACCCCAG CCTGGGGCCC CGGGCCACCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011248498.1 |
CDS | 658..1980 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011250196.2 |
1 | ATGGTTCCAG AGCCCGGCCC TGTCAACAGT AGCACCCCAG CCTGGGGCCC CGGGCCACCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Serotonin 5-HT6 receptors affect cognition in a mouse model of Alzheimer's disease by regulating cilia function. |
5-HT |