Gene Symbol | Ifrd1 |
Entrez Gene ID | 15982 |
Full Name | interferon-related developmental regulator 1 |
Synonyms | Ifnl,PC4,Tis7 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Ifrd1 cDNA ORF clone
Gene Symbol | Ifrd1 |
Entrez Gene ID | 15982 |
Full Name | interferon-related developmental regulator 1 |
Synonyms | Ifnl,PC4,Tis7 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_013562.2 | NP_038590.2 | interferon-related developmental regulator 1 |
XM_030246563.1 | XP_030102423.1 | interferon-related developmental regulator 1 isoform X1 |
Homo sapiens (human) | IFRD1 | NP_001007246.1 |
Oryza sativa (rice) | Os07g0588000 | NP_001060139.1 |
Arabidopsis thaliana (thale cress) | SAT32 | NP_564294.1 |
Xenopus tropicalis (tropical clawed frog) | ifrd1 | NP_001016124.1 |
Gallus gallus (chicken) | IFRD1 | NP_001001468.1 |
Drosophila melanogaster (fruit fly) | CG31694 | NP_722858.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP001032 | XP_003437180.1 |
Caenorhabditis elegans (roundworm) | F58B3.6 | NP_502197.2 |
Pan troglodytes (chimpanzee) | IFRD1 | XP_001167483.1 |
IFRD1 | XP_001099740.1 | |
Canis lupus familiaris (dog) | IFRD1 | XP_539525.2 |
Mus musculus (house mouse) | Ifrd1 | NP_038590.2 |
Danio rerio (zebrafish) | ifrd1 | NP_001070023.1 |
Oryza sativa (rice) | Os03g0448700 | NP_001050472.1 |
Bos taurus (cattle) | IFRD1 | NP_001029901.1 |
Rattus norvegicus (Norway rat) | Ifrd1 | NP_062115.1 |
A Novel Diterpenoid Suppresses Osteoclastogenesis and Promotes Osteogenesis by Inhibiting Ifrd1- and I?B?-Mediated p65 Nuclear Translocation.
Xie Z, Yu H, Sun X, Tang P, Jie Z, Chen S, Wang J, Qin A, Fan S
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research(2017 Nov)
The transcriptional modulator Ifrd1 controls PGC-1? expression under short-term adrenergic stimulation in brown adipocytes.
Park G, Horie T, Kanayama T, Fukasawa K, Iezaki T, Onishi Y, Ozaki K, Nakamura Y, Yoneda Y, Takarada T, Hinoi E
The FEBS journal284(5)784-795(2017 03)
The transcriptional modulator Ifrd1 is a negative regulator of BMP-2-dependent osteoblastogenesis.
Onishi Y, Park G, Iezaki T, Horie T, Kanayama T, Fukasawa K, Ozaki K, Hinoi E
Biochemical and biophysical research communications482(2)329-334(2017 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
adrenergic stimulation induced complex formation between Ifrd1, Sp1 and mSIN3B, which is a component of the SIN complex containing histone deacetylase, in brown adipocytes. These findings, therefore, suggest that Ifrd1 could be a pivotal negative regulator of sympathetic regulation of thermogenic and mitochondrial gene expression in brown adipocytes by interacting with Sp1 and the mSIN3 complex.
Title: The transcriptional modulator Ifrd1 controls PGC-1? expression under short-term adrenergic stimulation in brown adipocytes.
These results suggest that BMP-2 directly induces Ifrd1 expression at the transcriptional level in osteoblasts via the Smad pathway, and Ifrd1 negatively regulates BMP-2-dependent osteoblastogenesis.
Title: The transcriptional modulator Ifrd1 is a negative regulator of BMP-2-dependent osteoblastogenesis.
Ifrd1 has a pivotal role in bone homeostasis through its expression in osteoblasts in vivo and represents a therapeutic target for bone diseases.
Title: The Transcriptional Modulator Interferon-Related Developmental Regulator 1 in Osteoblasts Suppresses Bone Formation and Promotes Bone Resorption.
High-fat diet feeding in the setting of tis7 deletion resulted in postresection anastomotic inflammation and small bowel obstruction.
Title: Tis7 deletion reduces survival and induces intestinal anastomotic inflammation and obstruction in high-fat diet-fed mice with short bowel syndrome.
TIS7 predominantly interacted with beta-catenin in the nucleus.
Title: Repression of adipogenesis through promotion of Wnt/?-catenin signaling by TIS7 up-regulated in adipocytes under hypoxia.
The following Ifrd1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ifrd1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu09616 | |
Clone ID Related Accession (Same CDS sequence) | NM_013562.2 | |
Accession Version | NM_013562.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1350bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-27 | |
Organism | Mus musculus(house mouse) | |
Product | interferon-related developmental regulator 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC157571.6 and BC043723.1. On Apr 1, 2009 this sequence version replaced NM_013562.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC043723.1, AK078888.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164134, SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCCGAAGA ACAAGAAGCG GAACGCTCCC CACCGCGGTG GCGGGGGTGG CGGCGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_038590.2 |
CDS | 234..1583 |
Translation |
Target ORF information:
Target ORF information:
|
NM_013562.2 |
1 | ATGCCGAAGA ACAAGAAGCG GAACGCTCCC CACCGCGGTG GCGGGGGTGG CGGCGGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu85999 | |
Clone ID Related Accession (Same CDS sequence) | XM_030246563.1 | |
Accession Version | XM_030246563.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1206bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | interferon-related developmental regulator 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000078.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAGCCACT GCAGCGGCTA TAGCGATCCT TCCAGTTTTG CGGAGGATGG GCCAGAAGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030102423.1 |
CDS | 852..2057 |
Translation |
Target ORF information:
Target ORF information:
|
XM_030246563.1 |
1 | ATGAGCCACT GCAGCGGCTA TAGCGATCCT TCCAGTTTTG CGGAGGATGG GCCAGAAGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
A Novel Diterpenoid Suppresses Osteoclastogenesis and Promotes Osteogenesis by Inhibiting Ifrd1- and I?B?-Mediated p65 Nuclear Translocation. |
The transcriptional modulator Ifrd1 controls PGC-1? expression under short-term adrenergic stimulation in brown adipocytes. |
The transcriptional modulator Ifrd1 is a negative regulator of BMP-2-dependent osteoblastogenesis. |