Igfbp5 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Summary

Gene Symbol	Igfbp5
Entrez Gene ID	16011
Full Name	insulin-like growth factor binding protein 5
Synonyms	AI256729,AW208790,IGFBP-5,IGFBP-5P
General protein information	Preferred Names insulin-like growth factor binding protein 5 Names insulin-like growth factor-binding protein 5 IBP-5 IGF-binding protein 5
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 1 Map Location: 1 C3\|1 36.94 cM

mRNA and Protein(s)

mRNA	Protein	Name
NM_010518.2	NP_034648.2	insulin-like growth factor-binding protein 5 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	IGFBP5	NP_001098797.1
Mus musculus (house mouse)	Igfbp5	NP_034648.2
Xenopus tropicalis (tropical clawed frog)	igfbp5	NP_001016042.1
Canis lupus familiaris (dog)	IGFBP5	XP_852885.1
Gallus gallus (chicken)	IGFBP5	XP_422069.3
	IGFBP5	XP_001087664.1
Danio rerio (zebrafish)	igfbp5b	NP_001092224.1
Homo sapiens (human)	IGFBP5	NP_000590.1
Pan troglodytes (chimpanzee)	IGFBP5	XP_003309513.1
Rattus norvegicus (Norway rat)	Igfbp5	NP_036949.1
Danio rerio (zebrafish)	igfbp5a	NP_001119935.1

Gene Ontology
Bibliography

Related articles in PubMed

ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice.
Ho L, van Dijk M, Chye STJ, Messerschmidt DM, Chng SC, Ong S, Yi LK, Boussata S, Goh GH, Afink GB, Lim CY, Dunn NR, Solter D, Knowles BB, Reversade B
Science (New York, N.Y.)357(6352)707-713(2017 08)

The Wilms tumor protein WT1 stimulates transcription of the gene encoding insulin-like growth factor binding protein 5 (IGFBP5).
M?ller M, Persson AB, Krueger K, Kirschner KM, Scholz H
Gene61921-29(2017 Jul)

A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.
Bibollet-Bahena O, Okafuji T, Hokamp K, Tear G, Mitchell KJ
PloS one12(5)e0177977(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data demonstrate that dysregulation of miR-143-3p:Igfbp5 interactions in satellite cells with age may be responsible for age-related changes in satellite cell function.
Title: Age-related changes in miR-143-3p:Igfbp5 interactions affect muscle regeneration.

proliferation of IGFBP5-mutated cancer cells is selectively blocked by IGF-1R inhibitors
Title: Secreted IGFBP5 mediates mTORC1-dependent feedback inhibition of IGF-1 signalling.

Results from mouse models suggest that inhibiting the up-regulation of IGFBP5 expression in peripheral nerves might prevent or slow down diabetic neuropathy disease progression
Title: Dysregulated IGFBP5 expression causes axon degeneration and motoneuron loss in diabetic neuropathy.

IGFBP-5 induces its pro-fibrotic effects, at least in part, via DOK5. IGFBP-5 and DOK5 are both increased in systemic sclerosis fibroblasts and tissues and may thus be acting in concert to promote fibrosis.
Title: The membrane-associated adaptor protein DOK5 is upregulated in systemic sclerosis and associated with IGFBP-5-induced fibrosis.

Igfbp2-5 are expressed in distinct and complementary patterns during cochlear development.
Title: Expression of insulin-like growth factor binding proteins during mouse cochlear development.

The following Igfbp5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Igfbp5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMu17958	NM_010518.2 Latest version!	Mus musculus insulin-like growth factor binding protein 5 (Igfbp5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Igfbp5 ( NM_010518.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_034648.2 Mus musculus insulin-like growth factor binding protein 5 (Igfbp5), mRNA.

Price & Availability↑

CloneID	OMu17958
Clone ID Related Accession (Same CDS sequence)	NM_010518.2
Accession Version	NM_010518.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 816bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Mus musculus(house mouse)
Product	insulin-like growth factor-binding protein 5 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC057447.1, BC029321.1 and BC018579.1. On Jul 16, 2005 this sequence version replaced NM_010518.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC057447.1, L12447.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849385, SAMN01164131 [ECO:0000348] ##Evidence-Data-END##

ATGGTGATCA GCGTGGTCCT CCTGCTGCTG GCCGCCTATG CCGTACCGGC TCAAGGCCTG 
GGTTCTTTCG TGCACTGTGA ACCCTGCGAC GAGAAAGCTC TGTCCATGTG TCCCCCCAGC 
CCTCTGGGCT GTGAGCTGGT CAAAGAGCCC GGCTGTGGCT GCTGCATGAC TTGCGCCCTG 
GCGGAGGGAC AGTCGTGTGG CGTCTACACG GAGCGCTGCG CCCAGGGTTT GCGCTGCCTC 
CCCCGGCAGG ATGAGGAGAA GCCGCTGCAC GCCCTGCTGC ACGGCCGCGG GGTTTGCCTC 
AACGAAAAGA GCTACGGCGA GCAAACCAAG ATAGAGAGAG ACTCTCGGGA ACACGAGGAA 
CCCACCACCT CCGAGATGGC TGAAGAGACC TACTCCCCCA AGGTCTTCCG GCCCAAGCAC 
ACTCGCATTT CCGAGCTGAA GGCTGAGGCT GTGAAGAAGG ACCGCAGAAA GAAGCTGACC 
CAGTCCAAGT TTGTGGGGGG TGCAGAGAAC ACTGCCCACC CCAGAGTCAT CCCTGCACCT 
GAGATGAGAC AGGAATCCGA ACAAGGCCCC TGCCGCAGAC ACATGGAAGC TTCCCTCCAG 
GAGTTCAAAG CCAGCCCACG CATGGTGCCC CGTGCTGTGT ACCTGCCCAA CTGTGACCGC 
AAAGGATTCT ACAAGAGAAA GCAGTGTAAG CCCTCCCGTG GCCGCAAACG TGGCATCTGC 
TGGTGTGTGG ACAAGTACGG AATGAAGCTG CCGGGCATGG AGTACGTGGA TGGGGACTTT 
CAGTGCCACG CCTTCGACAG CAGTAACGTT GAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_034648.2
CDS	727..1542
Translation	MVISVVLLLLAAYAVPAQGLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYGEQTKIERDSREHEEPTTSEMAEETYSPKVFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRVIPAPEMRQESEQGPCRRHMEASLQEFKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHAFDSSNVE

Target ORF information:

RefSeq Version	NM_010518.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus insulin-like growth factor binding protein 5 (Igfbp5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_010518.2

ORF Insert Sequence:

ATGGTGATCA GCGTGGTCCT CCTGCTGCTG GCCGCCTATG CCGTACCGGC TCAAGGCCTG 
GGTTCTTTCG TGCACTGTGA ACCCTGCGAC GAGAAAGCTC TGTCCATGTG TCCCCCCAGC 
CCTCTGGGCT GTGAGCTGGT CAAAGAGCCC GGCTGTGGCT GCTGCATGAC TTGCGCCCTG 
GCGGAGGGAC AGTCGTGTGG CGTCTACACG GAGCGCTGCG CCCAGGGTTT GCGCTGCCTC 
CCCCGGCAGG ATGAGGAGAA GCCGCTGCAC GCCCTGCTGC ACGGCCGCGG GGTTTGCCTC 
AACGAAAAGA GCTACGGCGA GCAAACCAAG ATAGAGAGAG ACTCTCGGGA ACACGAGGAA 
CCCACCACCT CCGAGATGGC TGAAGAGACC TACTCCCCCA AGGTCTTCCG GCCCAAGCAC 
ACTCGCATTT CCGAGCTGAA GGCTGAGGCT GTGAAGAAGG ACCGCAGAAA GAAGCTGACC 
CAGTCCAAGT TTGTGGGGGG TGCAGAGAAC ACTGCCCACC CCAGAGTCAT CCCTGCACCT 
GAGATGAGAC AGGAATCCGA ACAAGGCCCC TGCCGCAGAC ACATGGAAGC TTCCCTCCAG 
GAGTTCAAAG CCAGCCCACG CATGGTGCCC CGTGCTGTGT ACCTGCCCAA CTGTGACCGC 
AAAGGATTCT ACAAGAGAAA GCAGTGTAAG CCCTCCCGTG GCCGCAAACG TGGCATCTGC 
TGGTGTGTGG ACAAGTACGG AATGAAGCTG CCGGGCATGG AGTACGTGGA TGGGGACTTT 
CAGTGCCACG CCTTCGACAG CAGTAACGTT GAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice.
Science (New York, N.Y.)357(6352)707-713(2017 08)
Ho L,van Dijk M,Chye STJ,Messerschmidt DM,Chng SC,Ong S,Yi LK,Boussata S,Goh GH,Afink GB,Lim CY,Dunn NR,Solter D,Knowles BB,Reversade B

The Wilms tumor protein WT1 stimulates transcription of the gene encoding insulin-like growth factor binding protein 5 (IGFBP5).
Gene61921-29(2017 Jul)
M?ller M,Persson AB,Krueger K,Kirschner KM,Scholz H

A dual-strategy expression screen for candidate connectivity labels in the developing thalamus.
PloS one12(5)e0177977(2017)
Bibollet-Bahena O,Okafuji T,Hokamp K,Tear G,Mitchell KJ

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Igfbp5 cDNA ORF clone, Mus musculus(house mouse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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