Il11ra1 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Il11ra1 |
| Entrez Gene ID | 16157 |
| Full Name | interleukin 11 receptor, alpha chain 1 |
| Synonyms | AI314697,GP130,Il-11ra,Il11ra,Il11ra2,NR1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_010549.3 | NP_034679.1 | interleukin-11 receptor subunit alpha-1 precursor |
| NM_001163401.1 | NP_001156873.1 | interleukin-11 receptor subunit alpha-1 precursor |
| NM_001172054.1 | NP_001165525.1 | interleukin-11 receptor subunit alpha-1 precursor |
| Canis lupus familiaris (dog) | IL11RA | XP_005626799.1 |
| Mus musculus (house mouse) | Il11ra1 | NP_034679.1 |
| Mus musculus (house mouse) | Gm13305 | NP_001092818.1 |
| Mus musculus (house mouse) | Il11ra2 | NP_034680.3 |
| Gallus gallus (chicken) | IL11RA | NP_001038139.1 |
| IL11RA | XP_001093448.2 | |
| Xenopus tropicalis (tropical clawed frog) | il11ra | NP_001093752.1 |
| Homo sapiens (human) | IL11RA | NP_001136256.1 |
| Pan troglodytes (chimpanzee) | IL11RA | NP_001238787.1 |
| Bos taurus (cattle) | IL11RA | NP_001029511.1 |
| Rattus norvegicus (Norway rat) | Il11ra1 | NP_620816.1 |
| Mus musculus (house mouse) | LOC100861969 | XP_006542822.1 |
| Mus musculus (house mouse) | Gm2002 | NP_001094066.1 |
| Danio rerio (zebrafish) | il11ra | NP_001106971.1 |
Related articles in PubMed
IL-11 is a crucial determinant of cardiovascular fibrosis.
Schafer S, Viswanathan S, Widjaja AA, Lim WW, Moreno-Moral A, DeLaughter DM, Ng B, Patone G, Chow K, Khin E, Tan J, Chothani SP, Ye L, Rackham OJL, Ko NSJ, Sahib NE, Pua CJ, Zhen NTG, Xie C, Wang M, Maatz H, Lim S, Saar K, Blachut S, Petretto E, Schmidt S, Putoczki T, Guimar?es-Camboa N, Wakimoto H, van Heesch S, Sigmundsson K, Lim SL, Soon JL, Chao VTT, Chua YL, Tan TE, Evans SM, Loh YJ, Jamal MH, Ong KK, Chua KC, Ong BH, Chakaramakkil MJ, Seidman JG, Seidman CE, Hubner N, Sin KYK, Cook SA
Nature552(7683)110-115(2017 Dec)
Interleukin-11 classic but not trans-signaling is essential for fertility in mice.
Agthe M, Garbers Y, Putoczki T, Garbers C
Placenta5713-16(2017 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome.
Title: Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome.
In spite of clear changes in the temporal expression of both IL-11 and its receptor, no significant differences in motor function are found after spinal cord injury.
Title: Evaluating the role of IL-11, a novel cytokine in the IL-6 family, in a mouse model of spinal cord injury.
Signaling through the IL-35 receptor required the transcription factors STAT1 and STAT4.
Title: The composition and signaling of the IL-35 receptor are unconventional.
Demyelination and oligodendrocyte death are exacerbated in IL-11 receptor alpha-deficient mice, suggesting avenues to enhance oligodendrocyte viability and restrict central nervous system inflammation in multiple sclerosis.
Title: Proapoptotic and antiapoptotic actions of Stat1 versus Stat3 underlie neuroprotective and immunoregulatory functions of IL-11.
These results provide, at least in part, an explanation for the defective small decidua of mice lacking the Il11ra gene, and reveal for the first time that cyclin D3, CDKN1A (p21), and BIRC5 (Survivin) are targets of IL11 in the decidua.
Title: Involvement of cyclin D3, CDKN1A (p21), and BIRC5 (Survivin) in interleukin 11 stimulation of decidualization in mice.
The following Il11ra1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Il11ra1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu06340 | |
| Clone ID Related Accession (Same CDS sequence) | NM_010549.3 , NM_001163401.1 , NM_001172054.1 | |
| Accession Version | NM_010549.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1299bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-27 | |
| Organism | Mus musculus(house mouse) | |
| Product | interleukin-11 receptor subunit alpha-1 precursor | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY149476.1, AK159559.1 and AK146742.1. On Jul 18, 2009 this sequence version replaced NM_010549.2. Transcript Variant: This variant (1) represents use of an alternate promoter and 5' UTR, compared to variant 3. Variants 1-3 all encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X74953.1, BC057664.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGAGCAGCA GCTGCTCAGG GCTGACCAGG GTCCTGGTGG CCGTGGCTAC AGCCCTGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_034679.1 |
| CDS | 115..1413 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_010549.3 |
ORF Insert Sequence:
1 | ATGAGCAGCA GCTGCTCAGG GCTGACCAGG GTCCTGGTGG CCGTGGCTAC AGCCCTGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu06340 | |
| Clone ID Related Accession (Same CDS sequence) | NM_010549.3 , NM_001163401.1 , NM_001172054.1 | |
| Accession Version | NM_001163401.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1299bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-26 | |
| Organism | Mus musculus(house mouse) | |
| Product | interleukin-11 receptor subunit alpha-1 precursor | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY777524.1, AK159559.1 and AK146742.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Variants 1-3 all encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK146742.1, AK159559.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGAGCAGCA GCTGCTCAGG GCTGACCAGG GTCCTGGTGG CCGTGGCTAC AGCCCTGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001156873.1 |
| CDS | 110..1408 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001163401.1 |
ORF Insert Sequence:
1 | ATGAGCAGCA GCTGCTCAGG GCTGACCAGG GTCCTGGTGG CCGTGGCTAC AGCCCTGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu06340 | |
| Clone ID Related Accession (Same CDS sequence) | NM_010549.3 , NM_001163401.1 , NM_001172054.1 | |
| Accession Version | NM_001172054.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1299bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-27 | |
| Organism | Mus musculus(house mouse) | |
| Product | interleukin-11 receptor subunit alpha-1 precursor | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL807796.17. Transcript Variant: This variant (3) represents the longest transcript. Variants 1-3 all encode the same protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC069984.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGAGCAGCA GCTGCTCAGG GCTGACCAGG GTCCTGGTGG CCGTGGCTAC AGCCCTGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001165525.1 |
| CDS | 196..1494 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001172054.1 |
ORF Insert Sequence:
1 | ATGAGCAGCA GCTGCTCAGG GCTGACCAGG GTCCTGGTGG CCGTGGCTAC AGCCCTGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
IL-11 is a crucial determinant of cardiovascular fibrosis. |
|
Interleukin-11 classic but not trans-signaling is essential for fertility in mice. |