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IL7R cDNA ORF clone, Mus musculus(House mouse)

Gene Symbol IL7R
Entrez Gene ID 16197
Full Name interleukin 7 receptor
Synonyms CD127,IL-7Ralpha
General protein information
Preferred Names

interleukin 7 receptor

Names

interleukin-7 receptor subunit alpha
IL-7 receptor alpha chain
IL-7 receptor subunit alpha
IL-7R subunit alpha
IL-7R-alpha
IL-7RA
interleukin 7 receptor alpha chain

Gene Type protein-coding
Organism Mus musculus(House mouse)
Genome

15

15 A1|15 4.16 cM

Summary Interleukin-7 is a glycoptorein involved in the regulation of lymphopoiesis. Response of cells to IL7 is dependent on the presence of the interleukin 7 receptor (IL7R); the active receptor is a alpha/gamma chain heterodimer. The gamma(c) chain, which also associates with the interleukin-2 receptor, serves primarily to activate signal transduction by the IL7R complex, while the alpha chain of IL7R determines specific signaling events through its association with cytoplasmic signaling molecules. [provided by RefSeq, Jul 2008].

mRNA and Protein(s)

mRNA Protein Name
NM_008372.4 NP_032398.3 interleukin-7 receptor subunit alpha precursor
XM_017316439.1 XP_017171928.1 interleukin-7 receptor subunit alpha isoform X1



Canis lupus familiaris (dog) IL7R XP_855408.1
Bos taurus (cattle) IL7R NP_001192816.1
Mus musculus (house mouse) Il7r NP_032398.3
Macaca mulatta (rhesus monkey) IL7R XP_001092582.1
Pan troglodytes (chimpanzee) IL7R XP_517807.2
Gallus gallus (chicken) IL7R NP_001073575.1
Homo sapiens (human) IL7R NP_002176.2
Rattus norvegicus (Norway rat) Il7r NP_001099888.1


Related articles in PubMed

DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions.
Huang W, Thomas B, Flynn RA, Gavzy SJ, Wu L, Kim SV, Hall JA, Miraldi ER, Ng CP, Rigo F, Rigo FW, Meadows S, Montoya NR, Herrera NG, Domingos AI, Rastinejad F, Myers RM, Fuller-Pace FV, Bonneau R, Chang HY, Acuto O, Littman DR
Nature528(7583)517-22(2015 Dec)

IL-7 receptor deletion ameliorates diet-induced obesity and insulin resistance in mice.
Lee M, Song SJ, Choi MS, Yu R, Park T
Diabetologia58(10)2361-70(2015 Oct)

IL-7R signaling in regulatory T cells maintains peripheral and allograft tolerance in mice.
Schmaler M, Broggi MA, Lagarde N, Stöcklin BF, King CG, Finke D, Rossi SW
Proceedings of the National Academy of Sciences of the United States of America112(43)13330-5(2015 Oct)

An Enhancer of the IL-7 Receptor α-Chain Locus Controls IL-7 Receptor Expression and Maintenance of Peripheral T Cells.
Abe A, Tani-ichi S, Shitara S, Cui G, Yamada H, Miyachi H, Kitano S, Hara T, Abe R, Yoshikai Y, Ikuta K
Journal of immunology (Baltimore, Md. : 1950)195(7)3129-38(2015 Oct)

IL-7/IL-7 Receptor Signaling Differentially Affects Effector CD4+ T Cell Subsets Involved in Experimental Autoimmune Encephalomyelitis.
Arbelaez CA, Glatigny S, Duhen R, Eberl G, Oukka M, Bettelli E
Journal of immunology (Baltimore, Md. : 1950)195(5)1974-83(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These studies provide in vivo evidence that IL-7Ralpha signals positively regulate normal human B-cell production and proliferation beyond the fetal period and suggest that TSLP can replace IL-7 in providing these signals.
Title: TSLP or IL-7 provide an IL-7Rα signal that is critical for human B lymphopoiesis.

results suggest that LNK suppresses IL-7R/JAK/STAT signaling to restrict pro-/pre-B progenitor expansion and leukemia development, providing a pathogenic mechanism and a potential therapeutic approach for B-ALLs with LNK mutations.
Title: LNK/SH2B3 regulates IL-7 receptor signaling in normal and malignant B-progenitors.

Bcl6 promoted T follicular helper cell differentiation through antagonizing IL-7R / STAT5a axis.
Title: Genome-wide Analysis Identifies Bcl6-Controlled Regulatory Networks during T Follicular Helper Cell Differentiation.

IL-7R signaling in regulatory T cells maintains peripheral and allograft tolerance in mice.
Title: IL-7R signaling in regulatory T cells maintains peripheral and allograft tolerance in mice.

This work demonstrates that the CNS1 element controls IL-7Ralpha expression and maintenance of peripheral T cells, suggesting differential regulation of IL-7Ralpha expression between central and peripheral lymphoid organs.
Title: An Enhancer of the IL-7 Receptor α-Chain Locus Controls IL-7 Receptor Expression and Maintenance of Peripheral T Cells.

The following IL7R gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IL7R cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OMu22595 NM_008372.4
Latest version!
Mus musculus interleukin 7 receptor (Il7r), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $223.30
$319.00
OMu79005 XM_017316439.1
Latest version!
Mus musculus interleukin 7 receptor (Il7r), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 9-11 $223.30
$319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OMu22595
Clone ID Related Accession (Same CDS sequence) NM_008372.4
Accession Version NM_008372.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1380bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-03
Organism Mus musculus(House mouse)
Product interleukin-7 receptor subunit alpha precursor
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY776757.1, AK040364.1, AK042264.1 and BC089571.1. On Feb 22, 2008 this sequence version replaced NM_008372.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M29697.1, AK042264.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGATGGCTC TGGGTAGAGC TTTCGCTATA GTTTTCTGCT TAATTCAAGC TGTTTCTGGA 
GAAAGTGGAA ATGCCCAGGA TGGAGACCTA GAAGATGCAG ACGCGGACGA TCACTCCTTC
TGGTGCCACA GCCAGTTGGA AGTGGATGGA AGTCAACATT TATTGACTTG TGCTTTTAAT
GACTCAGACA TCAACACAGC TAATCTGGAA TTTCAAATAT GTGGGGCTCT TTTACGAGTG
AAATGCCTAA CTCTTAACAA GCTGCAAGAT ATATATTTTA TAAAGACATC AGAATTCTTA
CTGATTGGTA GCAGCAATAT ATGTGTGAAG CTTGGACAAA AGAATTTAAC TTGCAAAAAT
ATGGCTATAA ACACAATAGT TAAAGCCGAG GCTCCCTCTG ACCTGAAAGT CGTTTATCGC
AAAGAAGCAA ATGATTTTTT GGTGACATTT AATGCACCTC ACTTGAAAAA GAAATATTTA
AAAAAAGTAA AGCATGATGT GGCCTACCGC CCAGCAAGGG GTGAAAGCAA CTGGACGCAT
GTATCTTTAT TCCACACAAG AACAACAATC CCACAGAGAA AACTACGACC AAAAGCAATG
TATGAAATCA AAGTCCGATC CATTCCCCAT AACGATTACT TCAAAGGCTT CTGGAGCGAG
TGGAGTCCAA GTTCTACCTT CGAAACTCCA GAACCCAAGA ATCAAGGAGG ATGGGATCCT
GTCTTGCCAA GTGTCACCAT TCTGAGTTTG TTCTCTGTGT TTTTGTTGGT CATCTTAGCC
CATGTGCTAT GGAAAAAAAG GATTAAACCT GTCGTATGGC CTAGTCTCCC CGATCATAAG
AAAACTCTGG AACAACTATG TAAGAAGCCA AAAACGAGTC TGAATGTGAG TTTCAATCCC
GAAAGTTTCC TGGACTGCCA GATTCATGAG GTGAAAGGCG TTGAAGCCAG GGACGAGGTG
GAAAGTTTTC TGCCCAATGA TCTTCCTGCA CAGCCAGAGG AGTTGGAGAC ACAGGGACAC
AGAGCCGCTG TACACAGTGC AAACCGCTCG CCTGAGACTT CAGTCAGCCC ACCAGAAACA
GTTAGAAGAG AGTCACCCTT AAGATGCCTG GCTAGAAATC TGAGTACCTG CAATGCCCCT
CCACTCCTTT CCTCTAGGTC CCCTGACTAC AGAGATGGTG ACAGAAATAG GCCTCCTGTG
TATCAAGACT TGCTGCCAAA CTCTGGAAAC ACAAATGTCC CTGTCCCTGT CCCTCAACCA
TTGCCTTTCC AGTCGGGAAT CCTGATACCA GTTTCTCAGA GACAGCCCAT CTCCACTTCC
TCAGTACTGA ATCAAGAAGA AGCGTATGTC ACCATGTCTA GTTTTTACCA AAACAAATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_032398.3
CDS135..1514
Misc Feature(1)525..791
Misc Feature(2)786..800
Misc Feature(3)order(786..791,795..800)
Misc Feature(4)852..926
Misc Feature(5)948..974
Misc Feature(6)978..980
Exon (1)1..216
Exon (2)217..355
Exon (3)356..513
Exon (4)514..671
Exon (5)672..840
Exon (6)841..934
Exon (7)935..1010
Exon (8)1011..3210
Translation

Target ORF information:

RefSeq Version NM_008372.4
Organism Mus musculus(House mouse)
Definition Mus musculus interleukin 7 receptor (Il7r), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_008372.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGATGGCTC TGGGTAGAGC TTTCGCTATA GTTTTCTGCT TAATTCAAGC TGTTTCTGGA 
GAAAGTGGAA ATGCCCAGGA TGGAGACCTA GAAGATGCAG ACGCGGACGA TCACTCCTTC
TGGTGCCACA GCCAGTTGGA AGTGGATGGA AGTCAACATT TATTGACTTG TGCTTTTAAT
GACTCAGACA TCAACACAGC TAATCTGGAA TTTCAAATAT GTGGGGCTCT TTTACGAGTG
AAATGCCTAA CTCTTAACAA GCTGCAAGAT ATATATTTTA TAAAGACATC AGAATTCTTA
CTGATTGGTA GCAGCAATAT ATGTGTGAAG CTTGGACAAA AGAATTTAAC TTGCAAAAAT
ATGGCTATAA ACACAATAGT TAAAGCCGAG GCTCCCTCTG ACCTGAAAGT CGTTTATCGC
AAAGAAGCAA ATGATTTTTT GGTGACATTT AATGCACCTC ACTTGAAAAA GAAATATTTA
AAAAAAGTAA AGCATGATGT GGCCTACCGC CCAGCAAGGG GTGAAAGCAA CTGGACGCAT
GTATCTTTAT TCCACACAAG AACAACAATC CCACAGAGAA AACTACGACC AAAAGCAATG
TATGAAATCA AAGTCCGATC CATTCCCCAT AACGATTACT TCAAAGGCTT CTGGAGCGAG
TGGAGTCCAA GTTCTACCTT CGAAACTCCA GAACCCAAGA ATCAAGGAGG ATGGGATCCT
GTCTTGCCAA GTGTCACCAT TCTGAGTTTG TTCTCTGTGT TTTTGTTGGT CATCTTAGCC
CATGTGCTAT GGAAAAAAAG GATTAAACCT GTCGTATGGC CTAGTCTCCC CGATCATAAG
AAAACTCTGG AACAACTATG TAAGAAGCCA AAAACGAGTC TGAATGTGAG TTTCAATCCC
GAAAGTTTCC TGGACTGCCA GATTCATGAG GTGAAAGGCG TTGAAGCCAG GGACGAGGTG
GAAAGTTTTC TGCCCAATGA TCTTCCTGCA CAGCCAGAGG AGTTGGAGAC ACAGGGACAC
AGAGCCGCTG TACACAGTGC AAACCGCTCG CCTGAGACTT CAGTCAGCCC ACCAGAAACA
GTTAGAAGAG AGTCACCCTT AAGATGCCTG GCTAGAAATC TGAGTACCTG CAATGCCCCT
CCACTCCTTT CCTCTAGGTC CCCTGACTAC AGAGATGGTG ACAGAAATAG GCCTCCTGTG
TATCAAGACT TGCTGCCAAA CTCTGGAAAC ACAAATGTCC CTGTCCCTGT CCCTCAACCA
TTGCCTTTCC AGTCGGGAAT CCTGATACCA GTTTCTCAGA GACAGCCCAT CTCCACTTCC
TCAGTACTGA ATCAAGAAGA AGCGTATGTC ACCATGTCTA GTTTTTACCA AAACAAATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu79005
Clone ID Related Accession (Same CDS sequence) XM_017316439.1
Accession Version XM_017316439.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1011bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-22
Organism Mus musculus(House mouse)
Product interleukin-7 receptor subunit alpha isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000081.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTTCATAG TTCCCTGTCT GTGGTTTAGC AGGCACAGAG CTGGTTTGGG TCTCCCTCTC 
TCTCATTCAC TTGCACATAC AAGCGTGCTT CTTCTCTATT CTTTCTCTCT CTCTCTCTCT
CTCTCTCTCT CTCTCTCTCT CTCTCTCAGA ATGATGGCTC TGGGTAGAGC TTTCGCTATA
GTTTTCTGCT TAATTCAAGC TGTTTCTGGA GAAAGTGGAA ATGCCCAGGA TGGAGACCTA
GAAGATGCAG ACGCGGACGA TCACTCCTTC TGGTGCCACA GCCAGTTGGA AGTGGATGGA
AGTCAACATT TATTGACTTG TGCTTTTAAT GACTCAGACA TCAACACAGC TAATCTGGAA
TTTCAAATAT GTGGGGCTCT TTTACGAGTG AAATGCCTAA CTCTTAACAA GCTGCAAGAT
ATATATTTTA TAAAGACATC AGAATTCTTA CTGATTGGTA GCAGCAATAT ATGTGTGAAG
CTTGGACAAA AGAATTTAAC TTGCAAAAAT ATGGCTATAA ACACAATAGT TAAAGCCGAG
GCTCCCTCTG ACCTGAAAGT CGTTTATCGC AAAGAAGCAA ATGATTTTTT GGTGACATTT
AATGCACCTC ACTTGAAAAA GAAATATTTA AAAAAAGTAA AGCATGATGT GGCCTACCGC
CCAGCAAGGG GTGAAAGCAA CTGGACGCAT GTATCTTTAT TCCACACAAG AACAACAATC
CCACAGAGAA AACTACGACC AAAAGCAATG TATGAAATCA AAGTCCGATC CATTCCCCAT
AACGATTACT TCAAAGGCTT CTGGAGCGAG TGGAGTCCAA GTTCTACCTT CGAAACTCCA
GAACCCAAGA ATCAAGGAGG ATGGGATCCT GTCTTGCCAA GTGTCACCAT TCTGAGTTTG
TTCTCTGTGT TTTTGTTGGT CATCTTAGCC CATGTGCTAT GGAAAAAAAG GATTAAACCT
GTCGTATGGC CTAGTCTCCC CGATCATAAG AAAACTCTGG AACAACTATA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_017171928.1
CDS44..1054
Translation

Target ORF information:

RefSeq Version XM_017316439.1
Organism Mus musculus(House mouse)
Definition Mus musculus interleukin 7 receptor (Il7r), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_017316439.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTTCATAG TTCCCTGTCT GTGGTTTAGC AGGCACAGAG CTGGTTTGGG TCTCCCTCTC 
TCTCATTCAC TTGCACATAC AAGCGTGCTT CTTCTCTATT CTTTCTCTCT CTCTCTCTCT
CTCTCTCTCT CTCTCTCTCT CTCTCTCAGA ATGATGGCTC TGGGTAGAGC TTTCGCTATA
GTTTTCTGCT TAATTCAAGC TGTTTCTGGA GAAAGTGGAA ATGCCCAGGA TGGAGACCTA
GAAGATGCAG ACGCGGACGA TCACTCCTTC TGGTGCCACA GCCAGTTGGA AGTGGATGGA
AGTCAACATT TATTGACTTG TGCTTTTAAT GACTCAGACA TCAACACAGC TAATCTGGAA
TTTCAAATAT GTGGGGCTCT TTTACGAGTG AAATGCCTAA CTCTTAACAA GCTGCAAGAT
ATATATTTTA TAAAGACATC AGAATTCTTA CTGATTGGTA GCAGCAATAT ATGTGTGAAG
CTTGGACAAA AGAATTTAAC TTGCAAAAAT ATGGCTATAA ACACAATAGT TAAAGCCGAG
GCTCCCTCTG ACCTGAAAGT CGTTTATCGC AAAGAAGCAA ATGATTTTTT GGTGACATTT
AATGCACCTC ACTTGAAAAA GAAATATTTA AAAAAAGTAA AGCATGATGT GGCCTACCGC
CCAGCAAGGG GTGAAAGCAA CTGGACGCAT GTATCTTTAT TCCACACAAG AACAACAATC
CCACAGAGAA AACTACGACC AAAAGCAATG TATGAAATCA AAGTCCGATC CATTCCCCAT
AACGATTACT TCAAAGGCTT CTGGAGCGAG TGGAGTCCAA GTTCTACCTT CGAAACTCCA
GAACCCAAGA ATCAAGGAGG ATGGGATCCT GTCTTGCCAA GTGTCACCAT TCTGAGTTTG
TTCTCTGTGT TTTTGTTGGT CATCTTAGCC CATGTGCTAT GGAAAAAAAG GATTAAACCT
GTCGTATGGC CTAGTCTCCC CGATCATAAG AAAACTCTGG AACAACTATA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions.
Nature528(7583)517-22(2015 Dec)
Huang W,Thomas B,Flynn RA,Gavzy SJ,Wu L,Kim SV,Hall JA,Miraldi ER,Ng CP,Rigo F,Rigo FW,Meadows S,Montoya NR,Herrera NG,Domingos AI,Rastinejad F,Myers RM,Fuller-Pace FV,Bonneau R,Chang HY,Acuto O,Littman DR


book

IL-7 receptor deletion ameliorates diet-induced obesity and insulin resistance in mice.
Diabetologia58(10)2361-70(2015 Oct)
Lee M,Song SJ,Choi MS,Yu R,Park T


book

IL-7R signaling in regulatory T cells maintains peripheral and allograft tolerance in mice.
Proceedings of the National Academy of Sciences of the United States of America112(43)13330-5(2015 Oct)
Schmaler M,Broggi MA,Lagarde N,Stöcklin BF,King CG,Finke D,Rossi SW


book

An Enhancer of the IL-7 Receptor α-Chain Locus Controls IL-7 Receptor Expression and Maintenance of Peripheral T Cells.
Journal of immunology (Baltimore, Md. : 1950)195(7)3129-38(2015 Oct)
Abe A,Tani-ichi S,Shitara S,Cui G,Yamada H,Miyachi H,Kitano S,Hara T,Abe R,Yoshikai Y,Ikuta K


book

IL-7/IL-7 Receptor Signaling Differentially Affects Effector CD4+ T Cell Subsets Involved in Experimental Autoimmune Encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)195(5)1974-83(2015 Sep)
Arbelaez CA,Glatigny S,Duhen R,Eberl G,Oukka M,Bettelli E


 
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