Gene Symbol | Itga2 |
Entrez Gene ID | 16398 |
Full Name | integrin alpha 2 |
Synonyms | CD49B,DX5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Itga2 cDNA ORF clone
gRNAs
Gene Symbol | Itga2 |
Entrez Gene ID | 16398 |
Full Name | integrin alpha 2 |
Synonyms | CD49B,DX5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_008396.2 | NP_032422.2 | integrin alpha-2 precursor |
NM_008396.3 | NP_032422.2 | integrin alpha-2 precursor |
Bos taurus (cattle) | ITGA2 | NP_001159971.1 |
Mus musculus (house mouse) | Itga2 | NP_032422.2 |
Gallus gallus (chicken) | ITGA2 | XP_003643030.2 |
Danio rerio (zebrafish) | itga2.2 | XP_003199352.2 |
ITGA2 | XP_001095246.1 | |
Canis lupus familiaris (dog) | ITGA2 | XP_005619391.1 |
Rattus norvegicus (Norway rat) | Itga2 | XP_345157.5 |
Pan troglodytes (chimpanzee) | ITGA2 | XP_526928.2 |
Xenopus tropicalis (tropical clawed frog) | itga2 | XP_002933089.2 |
Homo sapiens (human) | ITGA2 | NP_002194.2 |
Danio rerio (zebrafish) | LOC100333484 | XP_003199351.2 |
Gene and Protein Expression Profiles in a Mouse Model of Collagen-Induced Arthritis.
Gwon SY, Rhee KJ, Sung HJ
International journal of medical sciences15(1)77-85(2018)
The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina.
Ha T, Moon KH, Dai L, Hatakeyama J, Yoon K, Park HS, Kong YY, Shimamura K, Kim JW
Cell reports19(2)351-363(2017 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
low expression of alpha2beta1 integrin increased protein kinase B (AKT) activation and alpha-smooth muscle actin (alpha-SMA) expression. This occurred due to the instability of phosphatase and tensin homolog (PTEN) in myofibroblasts on fibrillar collagen.
Title: Fibrillar Type I Collagen Enhances the Differentiation and Proliferation of Myofibroblasts by Lowering
A sulfonamide-type small-molecule inhibitor of alpha2beta1 integrin decreased average platelet adhesion in individuals with the C/T807T genotype but not in those harboring C807C.
Title: Platelet response to a small molecule inhibitor of ?2?1 integrin is associated with ITGA2 C807T dimorphism.
Ceacam1 is essential for normal integrin aIIbb3-mediated platelet function; the disruption of mouse Ceacam1 induced moderate integrin aIIbb3-mediated functional defects.
Title: CEACAM1 regulates integrin ?IIb?3-mediated functions in platelets.
HRG binds to alpha2 integrin through low-affinity interactions in a heparin sulfate-independent manner, thereby blocking endothelial cells adhesion to collagen I.
Title: Histidine-rich glycoprotein blocks collagen-binding integrins and adhesion of endothelial cells through low-affinity interaction with ?2 integrin.
LG3, through interactions with alpha2beta1 integrins on recipient-derived cells leading to activation of ERK1/2 and increased migration, favors myointimal thickening
Title: The perlecan fragment LG3 regulates homing of mesenchymal stem cells and neointima formation during vascular rejection.
The following Itga2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Itga2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu16695 | |
Clone ID Related Accession (Same CDS sequence) | NM_008396.2 , NM_008396.3 | |
Accession Version | NM_008396.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3537bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-11-25 | |
Organism | Mus musculus(house mouse) | |
Product | integrin alpha-2 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC065139.1. On or before May 4, 2006 this sequence version replaced XM_982915.1, NM_008396.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC065139.1, AK051050.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGGACCGG GACAGGCAGG GGGCGCGCTC CTGCTGCGGC TGCTAATGCT AGTTCAAGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032422.2 |
CDS | 109..3645 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGACCGG GACAGGCAGG GGGCGCGCTC CTGCTGCGGC TGCTAATGCT AGTTCAAGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu16695 | |
Clone ID Related Accession (Same CDS sequence) | NM_008396.2 , NM_008396.3 | |
Accession Version | NM_008396.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3537bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-29 | |
Organism | Mus musculus(house mouse) | |
Product | integrin alpha-2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK036572.1, BC065139.1, CT025598.9, AK028540.1 and CJ248007.1. On Apr 13, 2018 this sequence version replaced NM_008396.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK156604.1, AK051050.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGACCGG GACAGGCAGG GGGCGCGCTC CTGCTGCGGC TGCTAATGCT AGTTCAAGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032422.2 |
CDS | 168..3704 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGACCGG GACAGGCAGG GGGCGCGCTC CTGCTGCGGC TGCTAATGCT AGTTCAAGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Gene and Protein Expression Profiles in a Mouse Model of Collagen-Induced Arthritis. |
The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina. |