Gene Symbol | Kng1 |
Entrez Gene ID | 16644 |
Full Name | kininogen 1 |
Synonyms | Kng |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Kng1 cDNA ORF clone
Gene Symbol | Kng1 |
Entrez Gene ID | 16644 |
Full Name | kininogen 1 |
Synonyms | Kng |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006521812.3 | XP_006521875.1 | kininogen-1 isoform X1 |
NM_001102411.1 | NP_001095881.1 | kininogen-1 isoform 1 precursor |
NM_001102412.1 | NP_001095882.1 | kininogen-1 isoform 3 precursor |
NM_023125.3 | NP_075614.1 | kininogen-1 isoform 2 precursor |
XM_030248988.1 | XP_030104848.1 | kininogen-1 isoform X2 |
XM_006521812.2 | XP_006521875.1 | kininogen-1 isoform X1 |
XM_006521813.1 | XP_006521876.1 | kininogen-1 isoform X3 |
Pan troglodytes (chimpanzee) | KNG1 | XP_516935.3 |
Rattus norvegicus (Norway rat) | Kng2 | NP_036873.1 |
Xenopus tropicalis (tropical clawed frog) | kng1 | XP_002937873.2 |
Bos taurus (cattle) | KNG1 | NP_786968.2 |
Mus musculus (house mouse) | Kng1 | NP_001095881.1 |
Mus musculus (house mouse) | Kng2 | NP_958763.1 |
Homo sapiens (human) | KNG1 | NP_001095886.1 |
Canis lupus familiaris (dog) | KNG1 | XP_003434170.1 |
Gallus gallus (chicken) | KNG1 | XP_422766.2 |
KNG1 | XP_001101685.1 |
Limited role of kininogen in the host response during gram-negative pneumonia derived sepsis.
Ding C, Van't Veer C, Roelofs JJTH, Shukla M, McCrae KR, Revenko AS, Crosby J, van der Poll T
American journal of physiology. Lung cellular and molecular physiologyajplung002882017(2017 Nov)
Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO
Scientific reports740495(2017 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
uPAR mediates efferocytosis through high molecular weight kininogen interaction with phosphatidylserine on apoptotic cells
Title: High molecular weight kininogen binds phosphatidylserine and opsonizes urokinase plasminogen activator receptor-mediated efferocytosis.
mice deficient in KNG showed less severe blood-brain barrier damage and edema formation, and the local inflammatory response was reduced compared with controls.
Title: Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation.
The vascular compartment is the main site of AngI and bradykinin-(1-9) formation and metabolism.
Title: Genetic models provide unique insight into angiotensin and bradykinin peptides in the extravascular compartment of the heart in vivo.
mKng1 is responsible for production of plasma kininogen
Title: Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis.
in the kidney K2 is strongly expressed as both HMWK and LMWK, whereas K1 is not expressed as HMWK and expressed only very weakly as LMWK
Title: A second expressed kininogen gene in mice.
The following Kng1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kng1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu21010 | |
Clone ID Related Accession (Same CDS sequence) | NM_001102412.1 | |
Accession Version | NM_001102412.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-09 | |
Organism | Mus musculus(house mouse) | |
Product | kininogen-1 isoform 3 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC154540.2, AK005547.1 and AA277668.1. Transcript Variant: This variant (3) uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY660571.1, AY462058.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAAGCTCA TTACTACACT GCTCCTCTGC TCCGGACTCC TGCTGACTTT AACACAGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001095882.1 |
CDS | 145..1587 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001102412.1 |
1 | ATGAAGCTCA TTACTACACT GCTCCTCTGC TCCGGACTCC TGCTGACTTT AACACAGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu51890 | |
Clone ID Related Accession (Same CDS sequence) | XM_006521812.3 , XM_006521812.2 | |
Accession Version | XM_006521812.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1185bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | kininogen-1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006521812.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGCTCA TTACTACACT GCTCCTCTGC TCCGGACTCC TGCTGACTTT AACACAGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006521875.1 |
CDS | 225..1409 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006521812.2 |
1 | ATGAAGCTCA TTACTACACT GCTCCTCTGC TCCGGACTCC TGCTGACTTT AACACAGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu51891 | |
Clone ID Related Accession (Same CDS sequence) | XM_006521813.1 | |
Accession Version | XM_006521813.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1386bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | kininogen-1 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGCTCA TTACTACACT GCTCCTCTGC TCCGGACTCC TGCTGACTTT AACACAGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006521876.1 |
CDS | 225..1610 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006521813.1 |
1 | ATGAAGCTCA TTACTACACT GCTCCTCTGC TCCGGACTCC TGCTGACTTT AACACAGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu21009 | |
Clone ID Related Accession (Same CDS sequence) | NM_023125.3 | |
Accession Version | NM_023125.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1299bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-09 | |
Organism | Mus musculus(house mouse) | |
Product | kininogen-1 isoform 2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC154540.2, AK005547.1 and BY463622.1. On Aug 23, 2007 this sequence version replaced NM_023125.2. Transcript Variant: This variant (2) uses an alternate splice pattern in the 3' coding region, compared to variant 1. The resulting isoform (2), also known as LMW kininogen-I, has a shorter and distinct C-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK005547.1, BC018158.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164134 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAAGCTCA TTACTACACT GCTCCTCTGC TCCGGACTCC TGCTGACTTT AACACAGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_075614.1 |
CDS | 145..1443 |
Translation |
Target ORF information:
Target ORF information:
|
NM_023125.3 |
1 | ATGAAGCTCA TTACTACACT GCTCCTCTGC TCCGGACTCC TGCTGACTTT AACACAGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu51890 | |
Clone ID Related Accession (Same CDS sequence) | XM_006521812.3 , XM_006521812.2 | |
Accession Version | XM_006521812.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1185bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | kininogen-1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006521812.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGCTCA TTACTACACT GCTCCTCTGC TCCGGACTCC TGCTGACTTT AACACAGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006521875.1 |
CDS | 225..1409 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006521812.3 |
1 | ATGAAGCTCA TTACTACACT GCTCCTCTGC TCCGGACTCC TGCTGACTTT AACACAGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu86890 | |
Clone ID Related Accession (Same CDS sequence) | XM_030248988.1 | |
Accession Version | XM_030248988.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1041bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | kininogen-1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGCTCA TTACTACACT GCTCCTCTGC TCCGGACTCC TGCTGACTTT AACACAGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030104848.1 |
CDS | 225..1265 |
Translation |
Target ORF information:
Target ORF information:
|
XM_030248988.1 |
1 | ATGAAGCTCA TTACTACACT GCTCCTCTGC TCCGGACTCC TGCTGACTTT AACACAGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu03702 | |
Clone ID Related Accession (Same CDS sequence) | NM_001102411.1 | |
Accession Version | NM_001102411.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1986bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-09 | |
Organism | Mus musculus(house mouse) | |
Product | kininogen-1 isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC154540.2 and BC108936.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1), also known as HMW kininogen-I. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC108936.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849383, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAAGCTCA TTACTACACT GCTCCTCTGC TCCGGACTCC TGCTGACTTT AACACAGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001095881.1 |
CDS | 145..2130 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001102411.1 |
1 | ATGAAGCTCA TTACTACACT GCTCCTCTGC TCCGGACTCC TGCTGACTTT AACACAGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Limited role of kininogen in the host response during gram-negative pneumonia derived sepsis. |
Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. |