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Kras cDNA ORF clone, Mus musculus(house mouse)

Summary

Gene Symbol Kras
Entrez Gene ID 16653
Full Name Kirsten rat sarcoma viral oncogene homolog
Synonyms AI929937,K-Ras,K-Ras 2,K-ras,Ki-ras,Kras-2,Kras2,c-K-ras,c-Ki-ras,p21B,ras
General protein information
Preferred Names

Kirsten rat sarcoma viral oncogene homolog

Names

GTPase KRas
Kirsten rat sarcoma oncogene 2, expressed
p21 protein
v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
Gene Type protein-coding
Organism Mus musculus(house mouse)
Genome

6

6 G3|6 77.37 cM

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_006506919.3 XP_006506982.1 GTPase KRas isoform X2
NM_021284.6 NP_067259.4 GTPase KRas
XM_006506918.3 XP_006506981.1 GTPase KRas isoform X1

Pathways from BioSystems


Homologies


Canis lupus familiaris (dog) KRAS XP_003433608.2
Homo sapiens (human) KRAS NP_203524.1
Drosophila melanogaster (fruit fly) Ras85D NP_476699.1
Anopheles gambiae (African malaria mosquito) AgaP_AGAP002219 XP_307965.4
Xenopus tropicalis (tropical clawed frog) LOC100485959 XP_004920180.1
Pan troglodytes (chimpanzee) KRAS XP_003313842.1
Mus musculus (house mouse) Kras NP_067259.4
Caenorhabditis elegans (roundworm) let-60 NP_502213.3
Bos taurus (cattle) KRAS NP_001103471.1
Rattus norvegicus (Norway rat) Kras NP_113703.1
Gallus gallus (chicken) KRAS NP_001243091.1
Danio rerio (zebrafish) kras NP_001003744.1

Gene Ontology


Bibliography

Related articles in PubMed

Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA.
Coelho MA, de Carn? Tr?cesson S, Rana S, Zecchin D, Moore C, Molina-Arcas M, East P, Spencer-Dene B, Nye E, Barnouin K, Snijders AP, Lai WS, Blackshear PJ, Downward J
Immunity47(6)1083-1099.e6(2017 Dec)

Myc Cooperates with Ras by Programming Inflammation and Immune Suppression.
Kortlever RM, Sodir NM, Wilson CH, Burkhart DL, Pellegrinet L, Brown Swigart L, Littlewood TD, Evan GI
Cell171(6)1301-1315.e14(2017 Nov)

c-Jun N-terminal kinase in pancreatic tumor stroma augments tumor development in mice.
Sato T, Shibata W, Hikiba Y, Kaneta Y, Suzuki N, Ihara S, Ishii Y, Sue S, Kameta E, Sugimori M, Yamada H, Kaneko H, Sasaki T, Ishii T, Tamura T, Kondo M, Maeda S
Cancer science108(11)2156-2165(2017 Nov)

Mice expressing KrasG12D in hematopoietic multipotent progenitor cells develop neonatal myeloid leukemia.
Tarnawsky SP, Kobayashi M, Chan RJ, Yoder MC
The Journal of clinical investigation127(10)3652-3656(2017 10)

Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivity.
Turrell FK, Kerr EM, Gao M, Thorpe H, Doherty GJ, Cridge J, Shorthouse D, Speed A, Samarajiwa S, Hall BA, Griffiths M, Martins CP
Genes & development(2017 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RAS signaling can upregulate tumor cell PD-L1 expression through a mechanism involving increases in PD-L1 mRNA stability via modulation of the AU-rich element-binding protein tristetraprolin.
Title: Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA.

In a mouse lung model of KRas(G12D)-driven adenomas, co-activation of Myc drives the immediate transition to highly proliferative and invasive adenocarcinomas marked by highly inflammatory, angiogenic, and immune-suppressed stroma.
Title: Myc Cooperates with Ras by Programming Inflammation and Immune Suppression.

Transgenic mouse line expressing the human Ki-Ras bearing an activating mutation (Ki-Ras((G12V))) selectively in the mammary epithelium develop estrogen receptor alpha (ERalpha)-positive ductal adenocarcinomas with 100% incidence within 3-9 months after Ki-Ras((G12V)) induction.
Title: Conditional expression of Ki-Ras

a KrasG12D mouse model that reproducibly develops JMML-like disease. This model will prove useful for preclinical drug studies and for elucidating the developmental origins of pediatric neoplasms.
Title: Mice expressing KrasG12D in hematopoietic multipotent progenitor cells develop neonatal myeloid leukemia.

High KRAS expression is associated with Gastric Tumorigenesis.
Title: Oncogenic KRAS and p53 Loss Drive Gastric Tumorigenesis in Mice That Can Be Attenuated by E-Cadherin Expression.

The following Kras gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kras cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OMu37793 XM_006506918.3
Latest version!		 Mus musculus Kirsten rat sarcoma viral oncogene homolog (Kras), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $69.30
$99.00
OMu23142 NM_021284.6
Latest version!		 Mus musculus Kirsten rat sarcoma viral oncogene homolog (Kras), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OMu37794 XM_006506919.3
Latest version!		 Mus musculus Kirsten rat sarcoma viral oncogene homolog (Kras), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OMu37793
Clone ID Related Accession (Same CDS sequence) XM_006506918.3
Accession Version XM_006506918.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 570bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-22
Organism Mus musculus(house mouse)
Product GTPase KRas isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006506918.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
ATGACTGAGT ATAAACTTGT GGTGGTTGGA GCTGGTGGCG TAGGCAAGAG CGCCTTGACG 
ATACAGCTAA TTCAGAATCA CTTTGTGGAT GAGTATGACC CTACGATAGA GGACTCCTAC 
AGGAAACAAG TAGTAATTGA TGGAGAAACC TGTCTCTTGG ATATTCTCGA CACAGCAGGT 
CAAGAGGAGT ACAGTGCAAT GAGGGACCAG TACATGAGAA CTGGGGAGGG CTTTCTTTGT 
GTATTTGCCA TAAATAATAC TAAATCATTT GAAGATATTC ACCATTATAG AGAACAAATT 
AAAAGAGTAA AGGACTCTGA AGATGTGCCT ATGGTCCTGG TAGGGAATAA GTGTGATTTG 
CCTTCTAGAA CAGTAGACAC GAAACAGGCT CAGGAGTTAG CAAGGAGTTA CGGGATTCCG 
TTCATTGAGA CCTCAGCAAA GACAAGACAG AGAGTGGAGG ATGCTTTTTA TACATTGGTG 
AGAGAGATCC GACAGTACAG ATTGAAAAAA ATCAGCAAAG AAGAAAAGAC TCCTGGCTGT 
GTGAAAATTA AAAAATGCGT TATAATGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006506981.1
CDS255..824
Misc Feature(1)261..746
Misc Feature(2)282..305
Misc Feature(3)order(285..290,429..434)
Misc Feature(4)order(288..308,336..344,348..350,357..359,432..434,600..605,609..614,687..692)
Misc Feature(5)order(303..308,342..350,354..356,363..365,372..377,414..419,423..425,429..437,441..449,453..455,459..467,471..473,558..563,693..695)
Misc Feature(6)order(327..329,363..377)
Misc Feature(7)351..374
Misc Feature(8)357..359
Misc Feature(9)423..434
Misc Feature(10)429..485
Misc Feature(11)600..611
Misc Feature(12)687..695
Translation

Target ORF information:

RefSeq Version XM_006506918.3
Organism Mus musculus(house mouse)
Definition Mus musculus Kirsten rat sarcoma viral oncogene homolog (Kras), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_006506918.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGACTGAGT ATAAACTTGT GGTGGTTGGA GCTGGTGGCG TAGGCAAGAG CGCCTTGACG 
ATACAGCTAA TTCAGAATCA CTTTGTGGAT GAGTATGACC CTACGATAGA GGACTCCTAC 
AGGAAACAAG TAGTAATTGA TGGAGAAACC TGTCTCTTGG ATATTCTCGA CACAGCAGGT 
CAAGAGGAGT ACAGTGCAAT GAGGGACCAG TACATGAGAA CTGGGGAGGG CTTTCTTTGT 
GTATTTGCCA TAAATAATAC TAAATCATTT GAAGATATTC ACCATTATAG AGAACAAATT 
AAAAGAGTAA AGGACTCTGA AGATGTGCCT ATGGTCCTGG TAGGGAATAA GTGTGATTTG 
CCTTCTAGAA CAGTAGACAC GAAACAGGCT CAGGAGTTAG CAAGGAGTTA CGGGATTCCG 
TTCATTGAGA CCTCAGCAAA GACAAGACAG AGAGTGGAGG ATGCTTTTTA TACATTGGTG 
AGAGAGATCC GACAGTACAG ATTGAAAAAA ATCAGCAAAG AAGAAAAGAC TCCTGGCTGT 
GTGAAAATTA AAAAATGCGT TATAATGTAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu23142
Clone ID Related Accession (Same CDS sequence) NM_021284.6
Accession Version NM_021284.6 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 567bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2018-01-01
Organism Mus musculus(house mouse)
Product GTPase KRas
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK164065.1 and AC157091.6. On Nov 11, 2009 this sequence version replaced NM_021284.5. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK155064.1, SRR1660821.133153.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849386 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
ATGACTGAGT ATAAACTTGT GGTGGTTGGA GCTGGTGGCG TAGGCAAGAG CGCCTTGACG 
ATACAGCTAA TTCAGAATCA CTTTGTGGAT GAGTATGACC CTACGATAGA GGACTCCTAC 
AGGAAACAAG TAGTAATTGA TGGAGAAACC TGTCTCTTGG ATATTCTCGA CACAGCAGGT 
CAAGAGGAGT ACAGTGCAAT GAGGGACCAG TACATGAGAA CTGGGGAGGG CTTTCTTTGT 
GTATTTGCCA TAAATAATAC TAAATCATTT GAAGATATTC ACCATTATAG AGAACAAATT 
AAAAGAGTAA AGGACTCTGA AGATGTGCCT ATGGTCCTGG TAGGGAATAA GTGTGATTTG 
CCTTCTAGAA CAGTAGACAC GAAACAGGCT CAGGAGTTAG CAAGGAGTTA CGGGATTCCG 
TTCATTGAGA CCTCAGCAAA GACAAGACAG GGTGTTGACG ATGCCTTCTA TACATTAGTC 
CGAGAAATTC GAAAACATAA AGAAAAGATG AGCAAAGATG GGAAGAAGAA GAAGAAGAAG 
TCAAGGACAA GGTGTACAGT TATGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_067259.4
CDS195..761
Misc Feature(1)132..134
Misc Feature(2)201..686
Misc Feature(3)222..245
Misc Feature(4)order(225..230,369..374)
Misc Feature(5)order(228..248,276..284,288..290,297..299,372..374,540..545,549..554,627..632)
Misc Feature(6)240..692
Misc Feature(7)order(243..248,282..290,294..296,303..305,312..317,354..359,363..365,369..377,381..389,393..395,399..407,411..413,498..503,633..635)
Misc Feature(8)order(267..269,303..317)
Misc Feature(9)291..314
Misc Feature(10)297..299
Misc Feature(11)363..374
Misc Feature(12)369..425
Misc Feature(13)540..551
Misc Feature(14)627..635
Exon (1)1..183
Exon (2)184..305
Exon (3)306..484
Exon (4)485..644
Exon (5)645..4670
Translation

Target ORF information:

RefSeq Version NM_021284.6
Organism Mus musculus(house mouse)
Definition Mus musculus Kirsten rat sarcoma viral oncogene homolog (Kras), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_021284.6

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGACTGAGT ATAAACTTGT GGTGGTTGGA GCTGGTGGCG TAGGCAAGAG CGCCTTGACG 
ATACAGCTAA TTCAGAATCA CTTTGTGGAT GAGTATGACC CTACGATAGA GGACTCCTAC 
AGGAAACAAG TAGTAATTGA TGGAGAAACC TGTCTCTTGG ATATTCTCGA CACAGCAGGT 
CAAGAGGAGT ACAGTGCAAT GAGGGACCAG TACATGAGAA CTGGGGAGGG CTTTCTTTGT 
GTATTTGCCA TAAATAATAC TAAATCATTT GAAGATATTC ACCATTATAG AGAACAAATT 
AAAAGAGTAA AGGACTCTGA AGATGTGCCT ATGGTCCTGG TAGGGAATAA GTGTGATTTG 
CCTTCTAGAA CAGTAGACAC GAAACAGGCT CAGGAGTTAG CAAGGAGTTA CGGGATTCCG 
TTCATTGAGA CCTCAGCAAA GACAAGACAG GGTGTTGACG ATGCCTTCTA TACATTAGTC 
CGAGAAATTC GAAAACATAA AGAAAAGATG AGCAAAGATG GGAAGAAGAA GAAGAAGAAG 
TCAAGGACAA GGTGTACAGT TATGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu37794
Clone ID Related Accession (Same CDS sequence) XM_006506919.3
Accession Version XM_006506919.3 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 684bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-22
Organism Mus musculus(house mouse)
Product GTPase KRas isoform X2
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006506919.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
ATGACTGAGT ATAAACTTGT GGTGGTTGGA GCTGGTGGCG TAGGCAAGAG CGCCTTGACG 
ATACAGCTAA TTCAGAATCA CTTTGTGGAT GAGTATGACC CTACGATAGA GGACTCCTAC 
AGGAAACAAG TAGTAATTGA TGGAGAAACC TGTCTCTTGG ATATTCTCGA CACAGCAGGT 
CAAGAGGAGT ACAGTGCAAT GAGGGACCAG TACATGAGAA CTGGGGAGGG CTTTCTTTGT 
GTATTTGCCA TAAATAATAC TAAATCATTT GAAGATATTC ACCATTATAG AGAACAAATT 
AAAAGAGTAA AGGACTCTGA AGATGTGCCT ATGGTCCTGG TAGGGAATAA GTGTGATTTG 
CCTTCTAGAA CAGTAGACAC GAAACAGGCT CAGGAGTTAG CAAGGAGTTA CGGGATTCCG 
TTCATTGAGA CCTCAGCAAA GACAAGACAG AGAGTGGAGG ATGCTTTTTA TACATTGGTG 
AGAGAGATCC GACAGTACAG ATTGAAAAAA ATCAGCAAAG AAGAAAAGAC TCCTGGCTGT 
GTGAAAATTA AAAAATGCGT TATAATGGGT GTTGACGATG CCTTCTATAC ATTAGTCCGA 
GAAATTCGAA AACATAAAGA AAAGATGAGC AAAGATGGGA AGAAGAAGAA GAAGAAGTCA 
AGGACAAGGT GTACAGTTAT GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006506982.1
CDS255..938
Misc Feature(1)261..746
Misc Feature(2)282..305
Misc Feature(3)order(285..290,429..434)
Misc Feature(4)order(288..308,336..344,348..350,357..359,432..434,600..605,609..614,687..692)
Misc Feature(5)300..752
Misc Feature(6)order(303..308,342..350,354..356,363..365,372..377,414..419,423..425,429..437,441..449,453..455,459..467,471..473,558..563,693..695)
Misc Feature(7)order(327..329,363..377)
Misc Feature(8)351..374
Misc Feature(9)357..359
Misc Feature(10)423..434
Misc Feature(11)429..485
Misc Feature(12)600..611
Misc Feature(13)687..695
Translation

Target ORF information:

RefSeq Version XM_006506919.3
Organism Mus musculus(house mouse)
Definition Mus musculus Kirsten rat sarcoma viral oncogene homolog (Kras), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_006506919.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGACTGAGT ATAAACTTGT GGTGGTTGGA GCTGGTGGCG TAGGCAAGAG CGCCTTGACG 
ATACAGCTAA TTCAGAATCA CTTTGTGGAT GAGTATGACC CTACGATAGA GGACTCCTAC 
AGGAAACAAG TAGTAATTGA TGGAGAAACC TGTCTCTTGG ATATTCTCGA CACAGCAGGT 
CAAGAGGAGT ACAGTGCAAT GAGGGACCAG TACATGAGAA CTGGGGAGGG CTTTCTTTGT 
GTATTTGCCA TAAATAATAC TAAATCATTT GAAGATATTC ACCATTATAG AGAACAAATT 
AAAAGAGTAA AGGACTCTGA AGATGTGCCT ATGGTCCTGG TAGGGAATAA GTGTGATTTG 
CCTTCTAGAA CAGTAGACAC GAAACAGGCT CAGGAGTTAG CAAGGAGTTA CGGGATTCCG 
TTCATTGAGA CCTCAGCAAA GACAAGACAG AGAGTGGAGG ATGCTTTTTA TACATTGGTG 
AGAGAGATCC GACAGTACAG ATTGAAAAAA ATCAGCAAAG AAGAAAAGAC TCCTGGCTGT 
GTGAAAATTA AAAAATGCGT TATAATGGGT GTTGACGATG CCTTCTATAC ATTAGTCCGA 
GAAATTCGAA AACATAAAGA AAAGATGAGC AAAGATGGGA AGAAGAAGAA GAAGAAGTCA 
AGGACAAGGT GTACAGTTAT GTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Oncogenic RAS Signaling Promotes Tumor Immunoresistance by Stabilizing PD-L1 mRNA.
Immunity47(6)1083-1099.e6(2017 Dec)
Coelho MA,de Carn? Tr?cesson S,Rana S,Zecchin D,Moore C,Molina-Arcas M,East P,Spencer-Dene B,Nye E,Barnouin K,Snijders AP,Lai WS,Blackshear PJ,Downward J


book

Myc Cooperates with Ras by Programming Inflammation and Immune Suppression.
Cell171(6)1301-1315.e14(2017 Nov)
Kortlever RM,Sodir NM,Wilson CH,Burkhart DL,Pellegrinet L,Brown Swigart L,Littlewood TD,Evan GI


book

c-Jun N-terminal kinase in pancreatic tumor stroma augments tumor development in mice.
Cancer science108(11)2156-2165(2017 Nov)
Sato T,Shibata W,Hikiba Y,Kaneta Y,Suzuki N,Ihara S,Ishii Y,Sue S,Kameta E,Sugimori M,Yamada H,Kaneko H,Sasaki T,Ishii T,Tamura T,Kondo M,Maeda S


book

Mice expressing KrasG12D in hematopoietic multipotent progenitor cells develop neonatal myeloid leukemia.
The Journal of clinical investigation127(10)3652-3656(2017 10)
Tarnawsky SP,Kobayashi M,Chan RJ,Yoder MC


book

Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivity.
Genes & development(2017 Aug)
Turrell FK,Kerr EM,Gao M,Thorpe H,Doherty GJ,Cridge J,Shorthouse D,Speed A,Samarajiwa S,Hall BA,Griffiths M,Martins CP