Gene Symbol | Lipa |
Entrez Gene ID | 16889 |
Full Name | lysosomal acid lipase A |
Synonyms | AA960673,Lal,Lip-1,Lip1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Lipa cDNA ORF clone
Gene Symbol | Lipa |
Entrez Gene ID | 16889 |
Full Name | lysosomal acid lipase A |
Synonyms | AA960673,Lal,Lip-1,Lip1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001111100.1 | NP_001104570.1 | lysosomal acid lipase/cholesteryl ester hydrolase precursor |
NM_021460.3 | NP_067435.3 | lysosomal acid lipase/cholesteryl ester hydrolase precursor |
Homo sapiens (human) | LIPA | NP_001121077.1 |
Pan troglodytes (chimpanzee) | LIPA | XP_003312800.1 |
Caenorhabditis elegans (roundworm) | lipl-7 | NP_501877.2 |
Saccharomyces cerevisiae (baker's yeast) | TGL1 | NP_012782.1 |
Mus musculus (house mouse) | Lipa | NP_067435.3 |
Rattus norvegicus (Norway rat) | Lipa | NP_036864.3 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP001652 | XP_321444.5 |
Caenorhabditis elegans (roundworm) | lipl-4 | NP_504662.1 |
LIPA | XP_001085160.2 | |
Bos taurus (cattle) | LIPA | NP_001096793.1 |
Caenorhabditis elegans (roundworm) | lipl-5 | NP_503184.1 |
Caenorhabditis elegans (roundworm) | lipl-3 | NP_503233.1 |
Caenorhabditis elegans (roundworm) | lipl-2 | NP_505527.1 |
Neurospora crassa | NCU02148 | XP_964507.2 |
Xenopus tropicalis (tropical clawed frog) | lipa | NP_001015847.2 |
Canis lupus familiaris (dog) | LIPA | XP_005636708.1 |
Gallus gallus (chicken) | LIPA | XP_421661.3 |
Caenorhabditis elegans (roundworm) | lipl-1 | NP_506229.1 |
Caenorhabditis elegans (roundworm) | lipl-6 | NP_504755.2 |
Schizosaccharomyces pombe (fission yeast) | SPCC1672.09 | NP_587880.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_02622 | XP_003721170.1 |
Danio rerio (zebrafish) | lipf | NP_998569.1 |
Eremothecium gossypii | AGOS_AFR206C | NP_985753.1 |
CISD2 Haploinsufficiency Disrupts Calcium Homeostasis, Causes Nonalcoholic Fatty Liver Disease, and Promotes Hepatocellular Carcinoma.
Shen ZQ, Chen YF, Chen JR, Jou YS, Wu PC, Kao CH, Wang CH, Huang YL, Chen CF, Huang TS, Shyu YC, Tsai SF, Kao LS, Tsai TF
Cell reports21(8)2198-2211(2017 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
results indicate that LAL is the major acid RE hydrolase and required for functional retinoid homeostasis.
Title: Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover.
The activity of lysosomal acid lipase was also decreased on treatment of macrophages with each modified LDL.
Title: Role of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function: A Contributing Factor to Macrophage Dysfunction in Atherosclerosis?
hLAL expression reduced tumor-promoting myeloid-derived suppressive cells in the liver of lal(-/-) mice
Title: Hepatocyte-Specific Expression of Human Lysosome Acid Lipase Corrects Liver Inflammation and Tumor Metastasis in lal(-/-) Mice.
effect the loss of SOAT2 function has on tissue esterified cholesterol sequestration in lysosomal acid lipase-deficient mice in a model of cholesteryl ester storage disease
Title: Deletion of sterol O-acyltransferase 2 (SOAT2) function in mice deficient in lysosomal acid lipase (LAL) dramatically reduces esterified cholesterol sequestration in the small intestine and liver.
Lipolysis of triacylglycerol substrates by LAL is important for M2 macrophage activation, and its inhibition suppresses M2 activation.
Title: Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages.
The following Lipa gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Lipa cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu22026 | |
Clone ID Related Accession (Same CDS sequence) | NM_001111100.1 , NM_021460.3 | |
Accession Version | NM_001111100.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1194bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-26 | |
Organism | Mus musculus(house mouse) | |
Product | lysosomal acid lipase/cholesteryl ester hydrolase precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK164007.1, AK169567.1, BE449010.1, BE198807.1 and AA881350.1. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK164007.1, AK169567.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCAACTCC AGGGCCTGGT GTTCGTTTTC ACCATTGGGA TCCTGCTTTC TCGGGTGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001104570.1 |
CDS | 110..1303 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001111100.1 |
1 | ATGCAACTCC AGGGCCTGGT GTTCGTTTTC ACCATTGGGA TCCTGCTTTC TCGGGTGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu22026 | |
Clone ID Related Accession (Same CDS sequence) | NM_001111100.1 , NM_021460.3 | |
Accession Version | NM_021460.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1194bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Mus musculus(house mouse) | |
Product | lysosomal acid lipase/cholesteryl ester hydrolase precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK164007.1, AK149791.1, AK169567.1, BE449010.1, BE198807.1 and AA881350.1. On Dec 5, 2007 this sequence version replaced NM_021460.2. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC058564.1, AK154804.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849386, SAMN01164137 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCAACTCC AGGGCCTGGT GTTCGTTTTC ACCATTGGGA TCCTGCTTTC TCGGGTGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_067435.3 |
CDS | 114..1307 |
Translation |
Target ORF information:
Target ORF information:
|
NM_021460.3 |
1 | ATGCAACTCC AGGGCCTGGT GTTCGTTTTC ACCATTGGGA TCCTGCTTTC TCGGGTGCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CISD2 Haploinsufficiency Disrupts Calcium Homeostasis, Causes Nonalcoholic Fatty Liver Disease, and Promotes Hepatocellular Carcinoma. |