Gene Symbol | Ltb |
Entrez Gene ID | 16994 |
Full Name | lymphotoxin B |
Synonyms | AI662801,LTbeta,Tnfc,Tnfsf3,Tnlg1c,p33 |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Ltb cDNA ORF clone
gRNAs
Gene Symbol | Ltb |
Entrez Gene ID | 16994 |
Full Name | lymphotoxin B |
Synonyms | AI662801,LTbeta,Tnfc,Tnfsf3,Tnlg1c,p33 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_008518.2 | NP_032544.1 | lymphotoxin-beta |
Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM
Hu Z, Chen M, Zhou H, Tharakan A, Wang X, Qiu L, Liang S, Qin X, Zhang Y, Wang W, Xu Y, Ying Z
Toxicology390100-108(2017 09)
Increased Abundance of M Cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility.
Donaldson DS, Sehgal A, Rios D, Williams IR, Mabbott NA
PLoS pathogens12(12)e1006075(2016 Dec)
Comparative genomic analysis of eutherian tumor necrosis factor ligand genes.
Premzl M
Immunogenetics68(2)125-32(2016 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
TNF/Lymphotoxin alpha/beta deficiency influences PM2.5 exposure-induced response of energy metabolism through alterations in both food intake and energy expenditure.
Title: Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM
The expression of lymphotoxin (LT)-B was significantly downregulated in the absence of T cells from nude mice and was recovered after the transfusion of T cells.
Title: T lymphocytes maintain structure and function of fibroblastic reticular cells via lymphotoxin (LT)-B.
Expression of LT alpha and beta on acinar cells in mice led to chronic pancreatitis and sufficed to reproduce key features of human autoimmune pancreatitis including the development of autoimmunity and AIP associated secondary extra pancreatic pathologies.
Title: The role of lymphotoxin signaling in the development of autoimmune pancreatitis and associated secondary extra-pancreatic pathologies.
TNF is able to upregulate LT-beta expression in hepatic cells at the transcriptional level by the binding of NF-kappaB p50/p65 heterodimers and Ets1 to their respective sites in the LT-beta promoter.
Title: TNF-inducible expression of lymphotoxin-? in hepatic cells: an essential role for NF-?B and Ets1 transcription factors.
Lymphotoxin-beta-receptor (LTbetaR) signaling, a pathway essential for lymphoid organogenesis, abrogates tertiary lymphoid organ development in heart transplantation.
Title: Blocking lymphotoxin signaling abrogates the development of ectopic lymphoid tissue within cardiac allografts and inhibits effector antibody responses.
The following Ltb gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ltb cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu16496 | |
Clone ID Related Accession (Same CDS sequence) | NM_008518.2 | |
Accession Version | NM_008518.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 921bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-22 | |
Organism | Mus musculus(house mouse) | |
Product | lymphotoxin-beta | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CR974444.18, U16985.1 and BC064062.1. On Dec 5, 2007 this sequence version replaced NM_008518.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript from the same strain was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U16985.1, BC114919.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGGGACAC GGGGACTGCA GGGCCTGGGT GGGAGACCCC AGGGGAGGGG CTGCCTCTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032544.1 |
CDS | 16..936 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGGGGACAC GGGGACTGCA GGGCCTGGGT GGGAGACCCC AGGGGAGGGG CTGCCTCTTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Inactivation of TNF/LT locus alters mouse metabolic response to concentrated ambient PM |
Increased Abundance of M Cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility. |
Comparative genomic analysis of eutherian tumor necrosis factor ligand genes. |