Gene Symbol | Msh2 |
Entrez Gene ID | 17685 |
Full Name | mutS homolog 2 |
Synonyms | AI788990 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Msh2 cDNA ORF clone
Gene Symbol | Msh2 |
Entrez Gene ID | 17685 |
Full Name | mutS homolog 2 |
Synonyms | AI788990 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_008628.3 | NP_032654.1 | DNA mismatch repair protein Msh2 |
NM_008628.2 | NP_032654.1 | DNA mismatch repair protein Msh2 |
Rattus norvegicus (Norway rat) | Msh2 | NP_112320.1 |
Gallus gallus (chicken) | MSH2 | XP_426110.4 |
Saccharomyces cerevisiae (baker's yeast) | MSH2 | NP_014551.1 |
Kluyveromyces lactis | KLLA0F02706g | XP_455202.1 |
Eremothecium gossypii | AGOS_AFR603C | NP_986150.1 |
Schizosaccharomyces pombe (fission yeast) | msh2 | XP_001713136.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_00879 | XP_003718090.1 |
Danio rerio (zebrafish) | msh2 | NP_998689.1 |
Arabidopsis thaliana (thale cress) | MSH2 | NP_566804.3 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010282 | XP_319476.4 |
Homo sapiens (human) | MSH2 | NP_000242.1 |
Canis lupus familiaris (dog) | MSH2 | XP_538482.2 |
Bos taurus (cattle) | MSH2 | NP_001029756.1 |
Mus musculus (house mouse) | Msh2 | NP_032654.1 |
Drosophila melanogaster (fruit fly) | spel1 | NP_001246031.1 |
Neurospora crassa | NCU02230 | XP_959643.1 |
Xenopus tropicalis (tropical clawed frog) | msh2 | XP_002935427.2 |
Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1.
Als?e L, Sarno A, Carracedo S, Domanska D, Dingler F, Lirussi L, SenGupta T, Tekin NB, Jobert L, Alexandrov LB, Galashevskaya A, Rada C, Sandve GK, Rognes T, Krokan HE, Nilsen H
Scientific reports7(1)7199(2017 Aug)
Mismatch repair deficient hematopoietic stem cells are preleukemic stem cells.
Qing Y, Gerson SL
PloS one12(8)e0182175(2017)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Normal Msh2-deficient organoids showed increased inheritable transient cyst-like growth, which became independent of R-spondin. intestinal stem cell (ISC) proceeded faster in vitro than in vivo independent of the underlying genotype but more under Mutations in mismatch repair deficiency.
Title: Different in vivo and in vitro transformation of intestinal stem cells in mismatch repair deficiency.
Deletion of the MSH2 C-terminus severely affected the stability of the MSH2/MSH6 heterodimer and consequently strongly attenuated DNA mismatch repair. The C-terminal truncation MSH2 mutant predisposed mice to tumor formation.Mutations deleting the MSH2 C-terminus can therefore unambiguously be considered as pathogenic and a cause of Lynch syndrome.
Title: Truncation of the MSH2 C-terminal 60 amino acids disrupts effective DNA mismatch repair and is causative for Lynch syndrome.
Study shows that MSH2-/- mice develop spontaneous thymic lymphomas.
Title: Mismatch repair deficient hematopoietic stem cells are preleukemic stem cells.
Data show that in mutS homolog 2 protein Msh2(+/-) mice, azathioprine (Aza) induced a high incidence of microsatellite instability (MSI) lymphomas in a dose-dependent manner.
Title: Azathioprine induction of tumors with microsatellite instability: risk evaluation using a mouse model.
In Msh2-/- mice, red meat enhanced survival compared to control (p<0.01) and lowered total tumour burden compared to resistant starch (p<0.167).
Title: Role of Red Meat and Resistant Starch in Promutagenic Adduct Formation, MGMT Repair, Thymic Lymphoma and Intestinal Tumourigenesis in Msh2 -Deficient Mice.
The following Msh2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Msh2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu18389 | |
Clone ID Related Accession (Same CDS sequence) | NM_008628.3 , NM_008628.2 | |
Accession Version | NM_008628.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2808bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-26 | |
Organism | Mus musculus(house mouse) | |
Product | DNA mismatch repair protein Msh2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC163652.3. On Jul 13, 2018 this sequence version replaced NM_008628.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC047117.1, U21011.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGGTGC AGCCTAAGGA GACGCTGCAG TTGGAAGGCG CGGCCGAGGC GGGCTTCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032654.1 |
CDS | 65..2872 |
Translation |
Target ORF information:
Target ORF information:
|
NM_008628.3 |
1 | ATGGCGGTGC AGCCTAAGGA GACGCTGCAG TTGGAAGGCG CGGCCGAGGC GGGCTTCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu18389 | |
Clone ID Related Accession (Same CDS sequence) | NM_008628.3 , NM_008628.2 | |
Accession Version | NM_008628.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2808bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-12-09 | |
Organism | Mus musculus(house mouse) | |
Product | DNA mismatch repair protein Msh2 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC163652.3. On Nov 17, 2006 this sequence version replaced NM_008628.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC047117.1, AK157842.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCGGTGC AGCCTAAGGA GACGCTGCAG TTGGAAGGCG CGGCCGAGGC GGGCTTCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032654.1 |
CDS | 40..2847 |
Translation |
Target ORF information:
Target ORF information:
|
NM_008628.2 |
1 | ATGGCGGTGC AGCCTAAGGA GACGCTGCAG TTGGAAGGCG CGGCCGAGGC GGGCTTCGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Uracil Accumulation and Mutagenesis Dominated by Cytosine Deamination in CpG Dinucleotides in Mice Lacking UNG and SMUG1. |
Mismatch repair deficient hematopoietic stem cells are preleukemic stem cells. |