Gene Symbol | Nid2 |
Entrez Gene ID | 18074 |
Full Name | nidogen 2 |
Synonyms | AW547149,Ly111,NID-2,entactin-2,nidogen-2 |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Nid2 cDNA ORF clone
gRNAs
Gene Symbol | Nid2 |
Entrez Gene ID | 18074 |
Full Name | nidogen 2 |
Synonyms | AW547149,Ly111,NID-2,entactin-2,nidogen-2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_008695.2 | NP_032721.2 | nidogen-2 precursor |
Homo sapiens (human) | NID2 | NP_031387.3 |
Canis lupus familiaris (dog) | NID2 | XP_537445.4 |
Mus musculus (house mouse) | Nid2 | NP_032721.2 |
Danio rerio (zebrafish) | nid2a | XP_005169909.1 |
Gallus gallus (chicken) | NID2 | XP_421471.4 |
NID2 | XP_001098764.1 | |
Xenopus tropicalis (tropical clawed frog) | nid2 | NP_001090732.1 |
Pan troglodytes (chimpanzee) | NID2 | XP_001158556.2 |
Rattus norvegicus (Norway rat) | Nid2 | NP_001012005.2 |
Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO
Scientific reports740495(2017 Jan)
Laminins and Nidogens in the Pericellular Matrix of Chondrocytes: Their Role in Osteoarthritis and Chondrogenic Differentiation.
Schminke B, Frese J, Bode C, Goldring MB, Miosge N
The American journal of pathology186(2)410-8(2016 Feb)
The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3' processing.
Abe K, Yamamoto R, Franke V, Cao M, Suzuki Y, Suzuki MG, Vlahovicek K, Svoboda P, Schultz RM, Aoki F
The EMBO journal34(11)1523-37(2015 Jun)
The growth factor-like adipokine tartrate-resistant acid phosphatase 5a interacts with the rod G3 domain of adipocyte-produced nidogen-2.
Patlaka C, Mai HA, L?ng P, Andersson G
Biochemical and biophysical research communications454(3)446-52(2014 11)
Lung epithelial branching program antagonizes alveolar differentiation.
Chang DR, Martinez Alanis D, Miller RK, Ji H, Akiyama H, McCrea PD, Chen J
Proceedings of the National Academy of Sciences of the United States of America110(45)18042-51(2013 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Nidogen-2, a protein shown to be expressed intracellularly and for secretion by pre-adipocytes, was shown to interact, through its globular G3 domain, with TRAP 5a in vitro.
Title: The growth factor-like adipokine tartrate-resistant acid phosphatase 5a interacts with the rod G3 domain of adipocyte-produced nidogen-2.
finding demonstrates that nidogens, although homologous proteins, exert their effect on BM assembly through different binding domains, which may in turn result in alterations of BM structure and functions
Title: Different domains in nidogen-1 and nidogen-2 drive basement membrane formation in skin organotypic cocultures.
show that loss of nidogen 2, but not of nidogen 1, promotes lung metastasis of melanoma cells. Histological and ultrastructural analysis of nidogen 1- and 2-deficient lungs did not reveal differences in morphology and ultrastructure of basement membrane
Title: Absence of the basement membrane component nidogen 2, but not of nidogen 1, results in increased lung metastasis in mice.
Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain.
Title: Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain.
Neuromuscular junctions in mutant mice lacking nidogen-2 appear normal at birth, but become topologically abnormal as they mature
Title: A synaptic nidogen: developmental regulation and role of nidogen-2 at the neuromuscular junction.
The following Nid2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nid2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu22078 | |
Clone ID Related Accession (Same CDS sequence) | NM_008695.2 | |
Accession Version | NM_008695.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4212bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Mus musculus(house mouse) | |
Product | nidogen-2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY143483.1, AK164258.1, AK052839.1 and AY074820.1. On Jan 5, 2006 this sequence version replaced NM_008695.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC054746.1, AK140832.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTTTCGGG ACCCGACAGC CGGGTGGCTA ACACCGCCAT CACCGCTATC GCTGCTGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032721.2 |
CDS | 82..4293 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGTTTCGGG ACCCGACAGC CGGGTGGCTA ACACCGCCAT CACCGCTATC GCTGCTGGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. |
Laminins and Nidogens in the Pericellular Matrix of Chondrocytes: Their Role in Osteoarthritis and Chondrogenic Differentiation. |
The first murine zygotic transcription is promiscuous and uncoupled from splicing and 3' processing. |
The growth factor-like adipokine tartrate-resistant acid phosphatase 5a interacts with the rod G3 domain of adipocyte-produced nidogen-2. |
Lung epithelial branching program antagonizes alveolar differentiation. |