Gene Symbol | Nlk |
Entrez Gene ID | 18099 |
Full Name | nemo like kinase |
Synonyms | AI194375 |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Nlk cDNA ORF clone
gRNAs
Gene Symbol | Nlk |
Entrez Gene ID | 18099 |
Full Name | nemo like kinase |
Synonyms | AI194375 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_008702.3 | NP_032728.3 | serine/threonine-protein kinase NLK |
Mus musculus (house mouse) | Nlk | NP_032728.3 |
Homo sapiens (human) | NLK | NP_057315.3 |
Gallus gallus (chicken) | NLK | XP_415915.3 |
Drosophila melanogaster (fruit fly) | nmo | NP_729318.1 |
Caenorhabditis elegans (roundworm) | lit-1 | NP_001022806.1 |
Rattus norvegicus (Norway rat) | Nlk | NP_001178853.1 |
Danio rerio (zebrafish) | nlk2 | NP_001106957.1 |
Pan troglodytes (chimpanzee) | NLK | XP_001147662.2 |
Canis lupus familiaris (dog) | NLK | XP_868108.2 |
Bos taurus (cattle) | NLK | NP_001180182.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP005898 | XP_315928.3 |
Xenopus tropicalis (tropical clawed frog) | nlk | NP_001116885.1 |
Wip1 directly dephosphorylates NLK and increases Wnt activity during germ cell development.
Cho SJ, Cha BS, Kwon OS, Lim J, Shin DM, Han DW, Ishitani T, Jho EH, Fornace AJ, Cha HJ
Biochimica et biophysica acta1863(4)1013-1022(2017 Apr)
Correlated evolution between CK1? Protein and the Serine-rich Motif Contributes to Regulating the Mammalian Circadian Clock.
Xing L, An Y, Shi G, Yan J, Xie P, Qu Z, Zhang Z, Liu Z, Pan D, Xu Y
The Journal of biological chemistry292(1)161-171(2017 Jan)
Phosphorylation by NLK inhibits YAP-14-3-3-interactions and induces its nuclear localization.
Moon S, Kim W, Kim S, Kim Y, Song Y, Bilousov O, Kim J, Lee T, Cha B, Kim M, Kim H, Katanaev VL, Jho EH
EMBO reports18(1)61-71(2017 01)
Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart.
Liu R, Khalil H, Lin SJ, Sargent MA, York AJ, Molkentin JD
PloS one11(10)e0164897(2016)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
our data suggest that NLK/Nemo acts as an endogenous regulator of Hippo signaling by controlling nuclear localization and activity of YAP/Yorkie.
Title: Phosphorylation by NLK inhibits YAP-14-3-3-interactions and induces its nuclear localization.
NLK is a novel signaling molecule for proper lung development through the interconnection between epithelial and endothelial cells during lung morphogenesis
Title: Nemo-like kinase regulates the expression of vascular endothelial growth factor (VEGF) in alveolar epithelial cells.
NLK can phosphorylate the mutant polyglutamine-expanded androgen receptor protein, enhance its aggregation, and promote androgen receptor-dependent gene transcription by regulating androgen receptor-cofactor interactions.
Title: Nemo-like kinase is a novel regulator of spinal and bulbar muscular atrophy.
Nlk is a negative regulator of skeletal homeostasis.
Title: Nemo-like kinase regulates postnatal skeletal homeostasis.
either reducing NLK enzymatic activity or decreasing NLK expression levels can have beneficial effects against the toxicity induced by polyglutamine-expanded ATXN1
Title: Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1.
The following Nlk gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nlk cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu02584 | |
Clone ID Related Accession (Same CDS sequence) | NM_008702.3 | |
Accession Version | NM_008702.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1584bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Mus musculus(house mouse) | |
Product | serine/threonine-protein kinase NLK | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY137033.1, BY237029.1, BU923375.1, AK078118.1, CB234984.1, AK160340.1 and CO042120.1. On Jun 22, 2007 this sequence version replaced NM_008702.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC058652.1, SRR1660819.30727.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTCTCTTT GTGGCACAAG AGCCAACGCA AAAATGATGG CGGCTTACAA TGGCGGTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032728.3 |
CDS | 1160..2743 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGTCTCTTT GTGGCACAAG AGCCAACGCA AAAATGATGG CGGCTTACAA TGGCGGTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Wip1 directly dephosphorylates NLK and increases Wnt activity during germ cell development. |
Correlated evolution between CK1? Protein and the Serine-rich Motif Contributes to Regulating the Mammalian Circadian Clock. |
Phosphorylation by NLK inhibits YAP-14-3-3-interactions and induces its nuclear localization. |
Nemo-Like Kinase (NLK) Is a Pathological Signaling Effector in the Mouse Heart. |