Gene Symbol | Nrxn2 |
Entrez Gene ID | 18190 |
Full Name | neurexin II |
Synonyms | 6430591O13Rik,mKIAA0921 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Nrxn2 cDNA ORF clone
gRNAs
Gene Symbol | Nrxn2 |
Entrez Gene ID | 18190 |
Full Name | neurexin II |
Synonyms | 6430591O13Rik,mKIAA0921 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001205235.2 | NP_001192164.1 | neurexin-2 isoform 3 precursor |
NM_001205234.2 | NP_001192163.1 | neurexin-2 isoform 1 precursor |
NM_020253.4 | NP_064649.2 | neurexin-2 isoform 2 precursor |
NM_020253.3 | NP_064649.2 | neurexin-2 isoform 2 precursor |
NM_001205235.1 | NP_001192164.1 | neurexin-2 isoform 3 precursor |
NM_001205234.1 | NP_001192163.1 | neurexin-2 isoform 1 precursor |
NM_001369363.1 | NP_001356292.1 | neurexin-2 isoform 4 precursor |
Homo sapiens (human) | NRXN2 | NP_055895.1 |
Mus musculus (house mouse) | Nrxn2 | NP_001192163.1 |
Rattus norvegicus (Norway rat) | Nrxn2 | NP_446298.1 |
Danio rerio (zebrafish) | nrxn2a | NP_001073439.1 |
Danio rerio (zebrafish) | nrxn2b | NP_001073453.1 |
Xenopus tropicalis (tropical clawed frog) | nrxn2 | XP_004913566.1 |
NRXN2 | XP_001118257.2 | |
Canis lupus familiaris (dog) | NRXN2 | XP_005631577.1 |
Pan troglodytes (chimpanzee) | NRXN2 | XP_001165542.2 |
Bos taurus (cattle) | NRXN2 | NP_001179851.1 |
IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2?.
Tanabe Y, Naito Y, Vasuta C, Lee AK, Soumounou Y, Linhoff MW, Takahashi H
Nature communications8(1)408(2017 09)
Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins.
Chen LY, Jiang M, Zhang B, Gokce O, S?dhof TC
Neuron94(3)611-625.e4(2017 May)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
IgSF21 interacts with neurexin2alpha to induce presynaptic differentiation of inhibitory synapses, and mice lacking IgSF21 exhibit deficits in inhibitory synaptic transmission
Title: IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2?.
After pan-neurexin deletions, we observed in these synapses severe but dramatically different synaptic phenotypes that ranged from major impairments in their distribution and function (climbing-fiber synapses) to large decreases in synapse numbers (parvalbumin-positive synapses) and severe alterations in action potential-induced presynaptic Ca(2+) transients (somatostatin-positive synapses).
Title: Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins.
The results indicate that Nrx2alpha and NL1 are targets of Abeta oligomers and that prevention of this interaction reduces the deleterious impact of Abeta oligomers on synapses and cognition.
Title: Interaction of amyloid-? (A?) oligomers with neurexin 2? and neuroligin 1 mediates synapse damage and memory loss in mice.
Findings demonstrate that the heterozygous loss of alpha-neurexin I and alpha-neurexin II in mice leads to phenotypes relevant to autism and schizophrenia
Title: Heterozygous deletion of ?-neurexin I or ?-neurexin II results in behaviors relevant to autism and schizophrenia.
The loss of Nrxn2alpha plays a causal role in the genesis of autism-related behaviors in mice.
Title: Deletion of ?-neurexin II results in autism-related behaviors in mice.
The following Nrxn2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nrxn2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu84935 | |
Clone ID Related Accession (Same CDS sequence) | NM_001369363.1 | |
Accession Version | NM_001369363.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5133bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2020-01-01 | |
Organism | Mus musculus(house mouse) | |
Product | neurexin-2 isoform 4 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC167245.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## |
1 | ATGGCGCTCG GGAGTCGGTG GCAACCGCCA CCCCAGCTGC CGCCGCTGCT GTTGCTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001356292.1 |
CDS | 462..5594 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCGCTCG GGAGTCGGTG GCAACCGCCA CCCCAGCTGC CGCCGCTGCT GTTGCTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu02916 | |
Clone ID Related Accession (Same CDS sequence) | NM_001205234.2 , NM_001205234.1 | |
Accession Version | NM_001205234.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5112bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2020-01-01 | |
Organism | Mus musculus(house mouse) | |
Product | neurexin-2 isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC167245.2. On Apr 8, 2019 this sequence version replaced NM_001205234.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK147295.1, AK147665.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGCTCG GGAGTCGGTG GCAACCGCCA CCCCAGCTGC CGCCGCTGCT GTTGCTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001192163.1 |
CDS | 462..5573 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCGCTCG GGAGTCGGTG GCAACCGCCA CCCCAGCTGC CGCCGCTGCT GTTGCTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu02916 | |
Clone ID Related Accession (Same CDS sequence) | NM_001205234.2 , NM_001205234.1 | |
Accession Version | NM_001205234.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5112bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-22 | |
Organism | Mus musculus(house mouse) | |
Product | neurexin-2 isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK162611.1, AK147295.1, AC167245.2 and BM899646.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK147295.1, AK147665.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGCTCG GGAGTCGGTG GCAACCGCCA CCCCAGCTGC CGCCGCTGCT GTTGCTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001192163.1 |
CDS | 480..5591 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCGCTCG GGAGTCGGTG GCAACCGCCA CCCCAGCTGC CGCCGCTGCT GTTGCTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu02918 | |
Clone ID Related Accession (Same CDS sequence) | NM_001205235.2 , NM_001205235.1 | |
Accession Version | NM_001205235.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4512bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2020-01-01 | |
Organism | Mus musculus(house mouse) | |
Product | neurexin-2 isoform 3 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC167245.2. On Apr 8, 2019 this sequence version replaced NM_001205235.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BC145496.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGCTCG GGAGTCGGTG GCAACCGCCA CCCCAGCTGC CGCCGCTGCT GTTGCTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001192164.1 |
CDS | 462..4973 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCGCTCG GGAGTCGGTG GCAACCGCCA CCCCAGCTGC CGCCGCTGCT GTTGCTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu02918 | |
Clone ID Related Accession (Same CDS sequence) | NM_001205235.2 , NM_001205235.1 | |
Accession Version | NM_001205235.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4512bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-22 | |
Organism | Mus musculus(house mouse) | |
Product | neurexin-2 isoform 3 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK162611.1, AC167245.2 and BM899646.1. On or before Jan 4, 2012 this sequence version replaced XR_107151.1, XR_106195.1. Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: BC145496.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGCTCG GGAGTCGGTG GCAACCGCCA CCCCAGCTGC CGCCGCTGCT GTTGCTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001192164.1 |
CDS | 480..4991 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCGCTCG GGAGTCGGTG GCAACCGCCA CCCCAGCTGC CGCCGCTGCT GTTGCTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu11936 | |
Clone ID Related Accession (Same CDS sequence) | NM_020253.4 , NM_020253.3 | |
Accession Version | NM_020253.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4536bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2020-01-01 | |
Organism | Mus musculus(house mouse) | |
Product | neurexin-2 isoform 2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC167245.2. On Apr 8, 2019 this sequence version replaced NM_020253.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK129239.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGCTCG GGAGTCGGTG GCAACCGCCA CCCCAGCTGC CGCCGCTGCT GTTGCTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_064649.2 |
CDS | 462..4997 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCGCTCG GGAGTCGGTG GCAACCGCCA CCCCAGCTGC CGCCGCTGCT GTTGCTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu11936 | |
Clone ID Related Accession (Same CDS sequence) | NM_020253.4 , NM_020253.3 | |
Accession Version | NM_020253.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4536bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-22 | |
Organism | Mus musculus(house mouse) | |
Product | neurexin-2 isoform 2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC167245.2 and BM899646.1. On Apr 1, 2011 this sequence version replaced NM_020253.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK129239.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGCTCG GGAGTCGGTG GCAACCGCCA CCCCAGCTGC CGCCGCTGCT GTTGCTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_064649.2 |
CDS | 480..5015 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCGCTCG GGAGTCGGTG GCAACCGCCA CCCCAGCTGC CGCCGCTGCT GTTGCTGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2?. |
Conditional Deletion of All Neurexins Defines Diversity of Essential Synaptic Organizer Functions for Neurexins. |