Kat2b cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Kat2b |
| Entrez Gene ID | 18519 |
| Full Name | K(lysine) acetyltransferase 2B |
| Synonyms | A930006P13Rik,AI461839,AW536563,Pcaf,p/CAF |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| XM_006523820.3 | XP_006523883.1 | histone acetyltransferase KAT2B isoform X1 |
| NM_020005.4 | NP_064389.2 | histone acetyltransferase KAT2B isoform 1 |
| NM_001190846.1 | NP_001177775.1 | histone acetyltransferase KAT2B isoform 2 |
| Canis lupus familiaris (dog) | KAT2B | XP_005634698.1 |
| Bos taurus (cattle) | KAT2B | XP_002684762.1 |
| Mus musculus (house mouse) | Kat2b | NP_064389.2 |
| Eremothecium gossypii | AGOS_AER297C | NP_985154.1 |
| LOC698283 | XP_001086807.1 | |
| Gallus gallus (chicken) | KAT2B | XP_426001.4 |
| Xenopus tropicalis (tropical clawed frog) | kat2b | XP_002932452.1 |
| Pan troglodytes (chimpanzee) | KAT2B | XP_516321.3 |
| Danio rerio (zebrafish) | kat2b | NP_001038499.1 |
| Magnaporthe oryzae (rice blast fungus) | MGG_03677 | XP_003716207.1 |
| Rattus norvegicus (Norway rat) | Pcaf | XP_003750665.2 |
| Saccharomyces cerevisiae (baker's yeast) | GCN5 | NP_011768.1 |
| Kluyveromyces lactis | KLLA0A05115g | XP_451225.1 |
| Homo sapiens (human) | KAT2B | NP_003875.3 |
| Caenorhabditis elegans (roundworm) | pcaf-1 | NP_491173.1 |
| Schizosaccharomyces pombe (fission yeast) | gcn5 | NP_594807.1 |
| Neurospora crassa | NCU10847 | XP_001728480.1 |
Related articles in PubMed
mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis.
Wan W, You Z, Xu Y, Zhou L, Guan Z, Peng C, Wong CCL, Su H, Zhou T, Xia H, Liu W
Molecular cell68(2)323-335.e6(2017 Oct)
The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development.
de Jong RCM, Ewing MM, de Vries MR, Karper JC, Bastiaansen AJNM, Peters HAB, Baghana F, van den Elsen PJ, Gongora C, Jukema JW, Quax PHA
PloS one12(10)e0185820(2017)
Histone H3K9 Acetyltransferase PCAF Is Essential for Osteogenic Differentiation Through Bone Morphogenetic Protein Signaling and May Be Involved in Osteoporosis.
Zhang P, Liu Y, Jin C, Zhang M, Lv L, Zhang X, Liu H, Zhou Y
Stem cells (Dayton, Ohio)34(9)2332-41(2016 09)
KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response.
Rabhi N, Denechaud PD, Gromada X, Hannou SA, Zhang H, Rashid T, Salas E, Durand E, Sand O, Bonnefond A, Yengo L, Chavey C, Bonner C, Kerr-Conte J, Abderrahmani A, Auwerx J, Fajas L, Froguel P, Annicotte JS
Cell reports15(5)1051-1061(2016 05)
Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes.
Panda S, Nilsson JA, Gekara NO
Immunity43(4)647-59(2015 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These results uncover p300 as a direct target of mTORC1 and suggest that the mTORC1-p300 pathway plays a pivotal role in cell metabolism by coordinately controlling cell anabolism and catabolism
Title: mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis.
The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development.
Title: The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development.
histone H3K9 acetyltransferase PCAF plays a critical role in osteogenic differentiation of mesenchymal stem cells.
Title: Histone H3K9 Acetyltransferase PCAF Is Essential for Osteogenic Differentiation Through Bone Morphogenetic Protein Signaling and May Be Involved in Osteoporosis.
This study demonstrated that pcaf increase in skeletal muscle in muscle atrophy.
Title: Differential expression of HDAC and HAT genes in atrophying skeletal muscle.
Treatment with a pan-acetylase inhibitor, anacardic acid, reduced the binding affinity of p300 and PCAF to the NKX2.5, beta-MHC, Cx43 promoters and attenuated H3K9 hyperacetylation.
Title: Alcohol-induced histone H3K9 hyperacetylation and cardiac hypertrophy are reversed by a histone acetylases inhibitor anacardic acid in developing murine hearts.
The following Kat2b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kat2b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu11684 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_020005.4 | |
| Accession Version | NM_020005.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2442bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-12-29 | |
| Organism | Mus musculus(house mouse) | |
| Product | histone acetyltransferase KAT2B isoform 1 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC131785.3, BC082581.1 and AC140263.3. On Jul 3, 2010 this sequence version replaced NM_020005.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK156290.1, AK132486.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGCCGAGG CTGGCGGGGC CGGGTCCCCA GCACTGCCTC CCGCGCCCCC GCACGGTTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_064389.2 |
| CDS | 360..2801 |
| Misc Feature(1) | 525..1280 |
| Misc Feature(2) | 1761..2780 |
| Misc Feature(3) | 1950..2168 |
| Misc Feature(4) | order(2022..2030,2058..2063) |
| Misc Feature(5) | 2022..2030 |
| Misc Feature(6) | 2043..2063 |
| Misc Feature(7) | 2136..2147 |
| Misc Feature(8) | 2481..2780 |
| Misc Feature(9) | order(2556..2558,2571..2573,2580..2582,2697..2699,2709..2711,2727..2729) |
| Exon (1) | 1..608 |
| Exon (2) | 609..735 |
| Exon (3) | 736..881 |
| Exon (4) | 882..974 |
| Exon (5) | 975..1156 |
| Exon (6) | 1157..1348 |
| Exon (7) | 1349..1455 |
| Exon (8) | 1456..1578 |
| Exon (9) | 1579..1715 |
| Exon (10) | 1716..1924 |
| Exon (11) | 1925..2051 |
| Exon (12) | 2052..2162 |
| Exon (13) | 2163..2306 |
| Exon (14) | 2307..2421 |
| Exon (15) | 2422..2458 |
| Exon (16) | 2459..2522 |
| Exon (17) | 2523..2607 |
| Exon (18) | 2608..4654 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_020005.4 |
ORF Insert Sequence:
1 | ATGGCCGAGG CTGGCGGGGC CGGGTCCCCA GCACTGCCTC CCGCGCCCCC GCACGGTTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu53270 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006523820.3 | |
| Accession Version | XM_006523820.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2025bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-06-22 | |
| Organism | Mus musculus(house mouse) | |
| Product | histone acetyltransferase KAT2B isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000083.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006523820.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGACAGAC TCCTGGGAAT TGTGTTGGAT GTGGAGTACC TCTTCACCTG CGTCCACAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006523883.1 |
| CDS | 243..2267 |
| Misc Feature(1) | <243..746 |
| Misc Feature(2) | 1227..2246 |
| Misc Feature(3) | 1416..1634 |
| Misc Feature(4) | order(1488..1496,1524..1529) |
| Misc Feature(5) | 1947..2246 |
| Misc Feature(6) | order(2022..2024,2037..2039,2046..2048,2163..2165,2175..2177,2193..2195) |
| Translation |
Target ORF information:
Target ORF information:
|
XM_006523820.3 |
ORF Insert Sequence:
1 | ATGGACAGAC TCCTGGGAAT TGTGTTGGAT GTGGAGTACC TCTTCACCTG CGTCCACAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu01359 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001190846.1 | |
| Accession Version | NM_001190846.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2208bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-12-29 | |
| Organism | Mus musculus(house mouse) | |
| Product | histone acetyltransferase KAT2B isoform 2 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK030070.1 and AC140263.3. Transcript Variant: This variant (2) contains an alternate 5' exon and uses an alternate start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter and distinct N-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK030070.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGAGTCCTG AAATGGCAGA GGAGTCCTGT AAATGCAATG GCTGGAAGAA CCCTAACCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001177775.1 |
| CDS | 40..2247 |
| Misc Feature(1) | 4..6 |
| Misc Feature(2) | 61..726 |
| Misc Feature(3) | 1207..2226 |
| Misc Feature(4) | 1396..1614 |
| Misc Feature(5) | order(1468..1476,1504..1509) |
| Misc Feature(6) | 1927..2226 |
| Misc Feature(7) | order(2002..2004,2017..2019,2026..2028,2143..2145,2155..2157,2173..2175) |
| Exon (1) | 1..54 |
| Exon (2) | 55..181 |
| Exon (3) | 182..327 |
| Exon (4) | 328..420 |
| Exon (5) | 421..602 |
| Exon (6) | 603..794 |
| Exon (7) | 795..901 |
| Exon (8) | 902..1024 |
| Exon (9) | 1025..1161 |
| Exon (10) | 1162..1370 |
| Exon (11) | 1371..1497 |
| Exon (12) | 1498..1608 |
| Exon (13) | 1609..1752 |
| Exon (14) | 1753..1867 |
| Exon (15) | 1868..1904 |
| Exon (16) | 1905..1968 |
| Exon (17) | 1969..2053 |
| Exon (18) | 2054..4100 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001190846.1 |
ORF Insert Sequence:
1 | ATGAGTCCTG AAATGGCAGA GGAGTCCTGT AAATGCAATG GCTGGAAGAA CCCTAACCCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis. |
|
The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development. |
|
Histone H3K9 Acetyltransferase PCAF Is Essential for Osteogenic Differentiation Through Bone Morphogenetic Protein Signaling and May Be Involved in Osteoporosis. |
|
KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response. |
|
Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes. |