Plaa cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Plaa |
| Entrez Gene ID | 18786 |
| Full Name | phospholipase A2, activating protein |
| Synonyms | 2410007N06,AI536418,AU018445,AW208417,D4Ertd618e,PLA2P,PLAP,Ufd3 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_172695.2 | NP_766283.2 | phospholipase A-2-activating protein |
| Gallus gallus (chicken) | PLAA | XP_424941.2 |
| Danio rerio (zebrafish) | plaa | NP_997855.1 |
| Schizosaccharomyces pombe (fission yeast) | lub1 | NP_596478.2 |
| Arabidopsis thaliana (thale cress) | AT3G18860 | NP_850612.1 |
| Homo sapiens (human) | PLAA | NP_001026859.1 |
| Drosophila melanogaster (fruit fly) | Plap | NP_001245829.1 |
| Neurospora crassa | NCU00880 | XP_964796.2 |
| Canis lupus familiaris (dog) | PLAA | XP_531963.3 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP008620 | XP_314716.4 |
| PLAA | XP_001105698.1 | |
| Bos taurus (cattle) | PLAA | NP_001098805.1 |
| Saccharomyces cerevisiae (baker's yeast) | DOA1 | NP_012709.1 |
| Eremothecium gossypii | AGOS_AER448W | NP_985303.2 |
| Pan troglodytes (chimpanzee) | PLAA | XP_520517.2 |
| Mus musculus (house mouse) | Plaa | NP_766283.2 |
| Rattus norvegicus (Norway rat) | Plaa | NP_446318.3 |
| Kluyveromyces lactis | KLLA0B14410g | XP_452172.1 |
| Magnaporthe oryzae (rice blast fungus) | MGG_14014 | XP_003721359.1 |
| Xenopus tropicalis (tropical clawed frog) | plaa | NP_001116275.1 |
Related articles in PubMed
PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins.
Hall EA, Nahorski MS, Murray LM, Shaheen R, Perkins E, Dissanayake KN, Kristaryanto Y, Jones RA, Vogt J, Rivagorda M, Handley MT, Mali GR, Quidwai T, Soares DC, Keighren MA, McKie L, Mort RL, Gammoh N, Garcia-Munoz A, Davey T, Vermeren M, Walsh D, Budd P, Aligianis IA, Faqeih E, Quigley AJ, Jackson IJ, Kulathu Y, Jackson M, Ribchester RR, von Kriegsheim A, Alkuraya FS, Woods CG, Maher ER, Mill P
American journal of human genetics100(5)706-724(2017 May)
Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy.
Falik Zaccai TC, Savitzki D, Zivony-Elboum Y, Vilboux T, Fitts EC, Shoval Y, Kalfon L, Samra N, Keren Z, Gross B, Chasnyk N, Straussberg R, Mullikin JC, Teer JK, Geiger D, Kornitzer D, Bitterman-Deutsch O, Samson AO, Wakamiya M, Peterson JW, Kirtley ML, Pinchuk IV, Baze WB, Gahl WA, Kleta R, Anikster Y, Chopra AK
Brain : a journal of neurology140(2)370-386(2017 02)
Phospholipase A2 activating protein is required for 1?,25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C via Pdia3.
Doroudi M, Schwartz Z, Boyan BD
The Journal of steroid biochemistry and molecular biology132(1-2)48-56(2012 Oct)
miR-203 regulates nociceptive sensitization after incision by controlling phospholipase A2 activating protein expression.
Sun Y, Li XQ, Sahbaie P, Shi XY, Li WW, Liang DY, Clark JD
Anesthesiology117(3)626-38(2012 Sep)
An Armadillo motif in Ufd3 interacts with Cdc48 and is involved in ubiquitin homeostasis and protein degradation.
Zhao G, Li G, Schindelin H, Lennarz WJ
Proceedings of the National Academy of Sciences of the United States of America106(38)16197-202(2009 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
We demonstrate that PLAA is essential for neural function, through dual roles of (1) regulating post-endocytic trafficking of signaling receptors necessary for neural development and (2) directing sorting of synaptic vesicle (SV) components during recycling, essential for synaptic function.
Title: PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins.
Phospholipase A2 activating protein is required for 1alpha,25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C via Pdia3
Title: Phospholipase A2 activating protein is required for 1?,25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C via Pdia3.
miR-203 may regulate expression of the novel nociceptive mediator PLAA after incision.
Title: miR-203 regulates nociceptive sensitization after incision by controlling phospholipase A2 activating protein expression.
The following Plaa gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Plaa cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu15059 | |
| Clone ID Related Accession (Same CDS sequence) | NM_172695.2 | |
| Accession Version | NM_172695.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2385bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-18 | |
| Organism | Mus musculus(house mouse) | |
| Product | phospholipase A-2-activating protein | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CA490654.1, AK075934.1, DV646766.1 and AL732597.10. On Sep 15, 2006 this sequence version replaced NM_172695.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.122489.1, BC139355.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGCGAGCG GCGCCTCCAG ATACCGGCTG AGCTGCTCGC TCCCGGGCCA CGAACTGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_766283.2 |
| CDS | 223..2607 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_172695.2 |
ORF Insert Sequence:
1 | ATGGCGAGCG GCGCCTCCAG ATACCGGCTG AGCTGCTCGC TCCCGGGCCA CGAACTGGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
PLAA Mutations Cause a Lethal Infantile Epileptic Encephalopathy by Disrupting Ubiquitin-Mediated Endolysosomal Degradation of Synaptic Proteins. |
|
Phospholipase A2-activating protein is associated with a novel form of leukoencephalopathy. |
|
Phospholipase A2 activating protein is required for 1?,25-dihydroxyvitamin D3 dependent rapid activation of protein kinase C via Pdia3. |
|
miR-203 regulates nociceptive sensitization after incision by controlling phospholipase A2 activating protein expression. |
|
An Armadillo motif in Ufd3 interacts with Cdc48 and is involved in ubiquitin homeostasis and protein degradation. |