Gene Symbol | Psmb10 |
Entrez Gene ID | 19171 |
Full Name | proteasome (prosome, macropain) subunit, beta type 10 |
Synonyms | Mecl-1,Mecl1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Psmb10 cDNA ORF clone
Gene Symbol | Psmb10 |
Entrez Gene ID | 19171 |
Full Name | proteasome (prosome, macropain) subunit, beta type 10 |
Synonyms | Mecl-1,Mecl1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_013640.3 | NP_038668.2 | proteasome subunit beta type-10 |
XM_006530770.1 | XP_006530833.1 | proteasome subunit beta type-10 isoform X2 |
XM_006530769.1 | XP_006530832.1 | proteasome subunit beta type-10 isoform X1 |
PSMB10 | XP_001095570.1 | |
Canis lupus familiaris (dog) | PSMB10 | XP_546869.3 |
Mus musculus (house mouse) | Psmb10 | NP_038668.2 |
Homo sapiens (human) | PSMB10 | NP_002792.1 |
Danio rerio (zebrafish) | zgc:92791 | NP_001002543.1 |
Bos taurus (cattle) | PSMB10 | NP_001029212.1 |
Pan troglodytes (chimpanzee) | PSMB10 | XP_001166577.2 |
Rattus norvegicus (Norway rat) | Psmb10 | NP_001020808.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100489016 | XP_002941310.2 |
The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T?cell repertoire.
Basler M, Mundt S, Groettrup M
European journal of immunology(2017 Oct)
Knockout of immunoproteasome subunit ?2i ameliorates cardiac fibrosis and inflammation in DOCA/Salt hypertensive mice.
Yan W, Bi HL, Liu LX, Li NN, Liu Y, Du J, Wang HX, Li HH
Biochemical and biophysical research communications490(2)84-90(2017 08)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The knockout of beta2i ameliorates DOCA/salt-induced cardiac fibrosis and inflammation, and may be a novel potential therapeutic target for hypertensive heart diseases.
Title: Knockout of immunoproteasome subunit ?2i ameliorates cardiac fibrosis and inflammation in DOCA/Salt hypertensive mice.
LMP7 and MECL1 regulate cytokine expression, suggesting this system represents a novel mechanism for the regulation of cytokines and cytokine signaling
Title: A critical role for the inducible proteasomal subunits LMP7 and MECL1 in cytokine production by activated murine splenocytes.
Findings strongly support the concept that LMP7/MECL-1 proteasomes subunits actively function to regulate LPS-induced NO production by affecting the TRIF/TRAM pathway.
Title: The immunoproteasomes regulate LPS-induced TRIF/TRAM signaling pathway in murine macrophages.
The findings indicate that MECL-1 influences the homeostatic equilibrium between T-cell subsets, not through indirect extracellular signals, such as MHC-I expression or the cytokine milieu, but through direct effects on T-cell-intrinsic processes.
Title: The proteasome immunosubunit multicatalytic endopeptidase complex-like 1 is a T-cell-intrinsic factor influencing homeostatic expansion.
An in vivo function of MECL-1 codetermines the T cell repertoire for an antiviral cytotoxic T lymphocyte (CTL) response specific for lymphocytic choriomeningitis virus that is altered in MECL1-deficient mice.
Title: An altered T cell repertoire in MECL-1-deficient mice.
The following Psmb10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Psmb10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu19502 | |
Clone ID Related Accession (Same CDS sequence) | NM_013640.3 | |
Accession Version | NM_013640.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 822bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-26 | |
Organism | Mus musculus(house mouse) | |
Product | proteasome subunit beta type-10 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC159265.2, D85561.1 and BY686068.1. On Jul 2, 2009 this sequence version replaced NM_013640.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC004730.1, AK144096.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCTGAAGC AGGCAGTGGA ACCCACAGGA GGCTTCTCTT TCGAGAACTG CCAGAGGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_038668.2 |
CDS | 383..1204 |
Translation |
Target ORF information:
Target ORF information:
|
NM_013640.3 |
1 | ATGCTGAAGC AGGCAGTGGA ACCCACAGGA GGCTTCTCTT TCGAGAACTG CCAGAGGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu41289 | |
Clone ID Related Accession (Same CDS sequence) | XM_006530769.1 | |
Accession Version | XM_006530769.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 933bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | proteasome subunit beta type-10 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTGAAGC AGGCAGTGGA ACCCACAGGA GGCTTCTCTT TCGAGAACTG CCAGAGGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006530832.1 |
CDS | 445..1377 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006530769.1 |
1 | ATGCTGAAGC AGGCAGTGGA ACCCACAGGA GGCTTCTCTT TCGAGAACTG CCAGAGGAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu41290 | |
Clone ID Related Accession (Same CDS sequence) | XM_006530770.1 | |
Accession Version | XM_006530770.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 876bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | proteasome subunit beta type-10 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGTCCTT GGAACACGTC CTTCCGGGAC TTCGGGTTCC TCATGCACGC AAGACCGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006530833.1 |
CDS | 503..1378 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006530770.1 |
1 | ATGCGTCCTT GGAACACGTC CTTCCGGGAC TTCGGGTTCC TCATGCACGC AAGACCGGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The immunoproteasome subunit LMP7 is required in the murine thymus for filling up a hole in the T?cell repertoire. |
Knockout of immunoproteasome subunit ?2i ameliorates cardiac fibrosis and inflammation in DOCA/Salt hypertensive mice. |