Gene Symbol | Twf1 |
Entrez Gene ID | 19230 |
Full Name | twinfilin actin binding protein 1 |
Synonyms | A6,Ptk9,twinfilin |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Twf1 cDNA ORF clone
Gene Symbol | Twf1 |
Entrez Gene ID | 19230 |
Full Name | twinfilin actin binding protein 1 |
Synonyms | A6,Ptk9,twinfilin |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_008971.4 | NP_032997.3 | twinfilin-1 |
XM_006520638.1 | XP_006520701.1 | twinfilin-1 isoform X1 |
Homo sapiens (human) | TWF1 | NP_001229326.1 |
Bos taurus (cattle) | TWF1 | NP_001020491.1 |
Anopheles gambiae (African malaria mosquito) | TWF_ANOGA | XP_310246.2 |
Eremothecium gossypii | AGOS_ABR105C | NP_983052.2 |
Magnaporthe oryzae (rice blast fungus) | MGG_07617 | XP_003711539.1 |
Neurospora crassa | NCU07512 | XP_957984.2 |
Xenopus tropicalis (tropical clawed frog) | twf1 | NP_001011469.1 |
Mus musculus (house mouse) | Twf1 | NP_032997.3 |
Rattus norvegicus (Norway rat) | Twf1 | NP_001008521.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP003717 | XP_310245.5 |
LOC700686 | XP_002808023.1 | |
Canis lupus familiaris (dog) | TWF1 | XP_003433603.1 |
Caenorhabditis elegans (roundworm) | F38E9.5 | NP_510669.1 |
Schizosaccharomyces pombe (fission yeast) | twf1 | NP_588449.1 |
Gallus gallus (chicken) | TWF1 | NP_001265024.1 |
Danio rerio (zebrafish) | twf1b | NP_001002304.1 |
Drosophila melanogaster (fruit fly) | twf | NP_650338.1 |
Saccharomyces cerevisiae (baker's yeast) | TWF1 | NP_011594.3 |
Kluyveromyces lactis | KLLA0C15719g | XP_452902.1 |
Pan troglodytes (chimpanzee) | TWF1 | XP_001165700.2 |
Twinfilin 2a regulates platelet reactivity and turnover in mice.
Stritt S, Beck S, Becker IC, V?gtle T, Hakala M, Heinze KG, Du X, Bender M, Braun A, Lappalainen P, Nieswandt B
Blood130(15)1746-1756(2017 10)
Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers.
Nikolaou KC, Moulos P, Chalepakis G, Hatzis P, Oda H, Reinberg D, Talianidis I
The EMBO journal34(4)430-47(2015 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
FGF signaling promotes the expansion of A6-expressing liver cells partly via AKT-dependent activation of beta-Catenin expansion of A6(+ive) periportal cells and possibly by reprogramming of centrolobular hepatocytes.
Title: Fibroblast growth factor signaling regulates the expansion of A6-expressing hepatocytes in association with AKT-dependent ?-catenin activation.
like Twf1, mouse Twf2 is a filament barbed-end capping protein, and that two tissue-specific and biochemically distinct isoforms are generated from the Twf2 gene through alternative promoter usage
Title: Two biochemically distinct and tissue-specific twinfilin isoforms are generated from the mouse Twf2 gene by alternative promoter usage.
The crystal structure of twinfilin's C-terminal ADF-H domain in complex with an actin monomer, is presented.
Title: Structure of the actin-depolymerizing factor homology domain in complex with actin.
a novel model for how sequential interactions between actin monomers, twinfilin, capping protein, and actin filaments promote cytoskeletal dynamics
Title: Biological role and structural mechanism of twinfilin-capping protein interaction.
mammals have two twinfilin isoforms, which are differentially expressed and regulated through distinct cellular signaling pathways
Title: Mammals have two twinfilin isoforms whose subcellular localizations and tissue distributions are differentially regulated.
The following Twf1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Twf1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu19557 | |
Clone ID Related Accession (Same CDS sequence) | NM_008971.4 | |
Accession Version | NM_008971.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1053bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-20 | |
Organism | Mus musculus(house mouse) | |
Product | twinfilin-1 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC147160.2. On Nov 17, 2006 this sequence version replaced NM_008971.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC094034.1, AK077410.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGTCCCACC AGACAGGCAT CCAAGCAAGC GAAGATGTCA AAGAGATCTT TGCCCGAGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_032997.3 |
CDS | 49..1101 |
Translation |
Target ORF information:
Target ORF information:
|
NM_008971.4 |
1 | ATGTCCCACC AGACAGGCAT CCAAGCAAGC GAAGATGTCA AAGAGATCTT TGCCCGAGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu51083 | |
Clone ID Related Accession (Same CDS sequence) | XM_006520638.1 | |
Accession Version | XM_006520638.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 975bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | twinfilin-1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000081.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCCCACC AGACAGGCAT CCAAGAGCAA CTGGTGGTTG GCTCCTGTAG TCCACCTTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006520701.1 |
CDS | 109..1083 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006520638.1 |
1 | ATGTCCCACC AGACAGGCAT CCAAGAGCAA CTGGTGGTTG GCTCCTGTAG TCCACCTTCA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Twinfilin 2a regulates platelet reactivity and turnover in mice. |
Spontaneous development of hepatocellular carcinoma with cancer stem cell properties in PR-SET7-deficient livers. |