Ranbp1 cDNA ORF clone, Mus musculus(house mouse)

Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical Projection Neuron Generation.
Paronett EM, Meechan DW, Karpinski BA, LaMantia AS, Maynard TM
Cerebral cortex (New York, N.Y. : 1991)25(10)3977-93(2015 Oct)

Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge (22q11) deletion syndrome.
Karpinski BA, Maynard TM, Fralish MS, Nuwayhid S, Zohn IE, Moody SA, LaMantia AS
Disease models & mechanisms7(2)245-57(2014 Feb)

Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection.
Rothmeier E, Pfaffinger G, Hoffmann C, Harrison CF, Grabmayr H, Repnik U, Hannemann M, W?lke S, Bausch A, Griffiths G, M?ller-Taubenberger A, Itzen A, Hilbi H
PLoS pathogens9(9)e1003598(2013 Sep)

22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development.
Maynard TM, Gopalakrishna D, Meechan DW, Paronett EM, Newbern JM, LaMantia AS
Human molecular genetics22(2)300-12(2013 Jan)

Mice lacking Ran binding protein 1 are viable and show male infertility.
Nagai M, Moriyama T, Mehmood R, Tokuhiro K, Ikawa M, Okabe M, Tanaka H, Yoneda Y
FEBS letters585(5)791-6(2011 Mar)

Ranbp1 emerges as a microcephaly gene within the 22q11.2 deleted region that may contribute to altered cortical precursor proliferation and neurogenesis associated with broader 22q11.2 deletion.
Title: Ranbp1, Deleted in DiGeorge/22q11.2 Deletion Syndrome, is a Microcephaly Gene That Selectively Disrupts Layer 2/3 Cortical Projection Neuron Generation.

Data suggest Ran activation by RanBP1 in macrophages promotes Legionella phagosome formation and phagocytosis; LegG1 functions as bacterial Ran activator, localizes to phagosomes, and promotes microtubule stabilization, phagocytosis, and replication.
Title: Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection.

The dramatic decrease in "RanBP" activity impairs germ cell viability and affects spermatogenesis decisively in RanBP1-knockout mice.
Title: Mice lacking Ran binding protein 1 are viable and show male infertility.

Downregulation of the Ran GTPase effector RanBP1 is required for nuclear reorganisation.
Title: Nuclear reformation after mitosis requires downregulation of the Ran GTPase effector RanBP1 in mammalian cells.

Tax directly binds Ran and Ran-binding protein-1, locates to centrosomes/spindle poles, and causes supernumerary centrosomes
Title: Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein.