Gene Symbol | Rgn |
Entrez Gene ID | 19733 |
Full Name | regucalcin |
Synonyms | AI265316,GNL,SMP30 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Rgn cDNA ORF clone
Gene Symbol | Rgn |
Entrez Gene ID | 19733 |
Full Name | regucalcin |
Synonyms | AI265316,GNL,SMP30 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_009060.2 | NP_033086.1 | regucalcin |
XM_006527572.2 | XP_006527635.1 | regucalcin isoform X1 |
XM_006527572.3 | XP_006527635.1 | regucalcin isoform X1 |
Drosophila melanogaster (fruit fly) | regucalcin | NP_727588.2 |
Kluyveromyces lactis | KLLA0F04301g | XP_455274.1 |
Eremothecium gossypii | AGOS_ABL098W | NP_982849.1 |
Bos taurus (cattle) | RGN | NP_776382.1 |
Homo sapiens (human) | RGN | NP_004674.1 |
RGN | XP_001090835.1 | |
Mus musculus (house mouse) | Rgn | NP_033086.1 |
Danio rerio (zebrafish) | rgn | NP_991309.1 |
Drosophila melanogaster (fruit fly) | smp-30 | NP_731942.1 |
Saccharomyces cerevisiae (baker's yeast) | YBR053C | NP_009609.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_05015 | XP_003712519.1 |
Neurospora crassa | NCU00326 | XP_957797.1 |
Xenopus tropicalis (tropical clawed frog) | rgn | NP_001006822.1 |
Pan troglodytes (chimpanzee) | RGN | XP_003317492.1 |
Canis lupus familiaris (dog) | RGN | XP_538011.3 |
Rattus norvegicus (Norway rat) | Rgn | NP_113734.1 |
Gallus gallus (chicken) | RGN | NP_990060.1 |
Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice.
Suzuki Y, Sato T, Sugimoto M, Baskoro H, Karasutani K, Mitsui A, Nurwidya F, Arano N, Kodama Y, Hirano SI, Ishigami A, Seyama K, Takahashi K
Biochemical and biophysical research communications492(1)74-81(2017 10)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The phosphorylated eNOS and Akt levels and VEGF levels in ischemic muscle were lower in SMP30 KO and old mice than in young mice. Deficiency of SMP30 exacerbates oxidative stress related to NADPH oxidase activity enhancement and impairs eNOS activity, which leads to rarefaction of angiogenesis induced by ischemia
Title: Senescence marker protein-30 deficiency impairs angiogenesis under ischemia.
Results suggested that SMP30 deficiency augments myocardial Ischemia/Reperfusion injury through reactive oxygen species generation and attenuation of Akt activation.
Title: Deficiency of Senescence Marker Protein 30 Exacerbates Cardiac Injury after Ischemia/Reperfusion.
This is the first report that stem cell replacement increased the expression of SMP30 in the liver, and may help prevent fibrosis in the liver of db/db mice.
Title: Stem Cell Replacement Improves Expression of SMP30 in db/db Mice.
SMP30/GNL-positive cells localized around the central veins of livers of mice and decreased numerically with aging. Nuclear SMP30/GNL protein might be a regulatory factor specific for genes whose expression governs transcription and the aging process.
Title: Age-associated decrease of senescence marker protein-30/gluconolactonase in individual mouse liver cells: Immunohistochemistry and immunofluorescence.
SMP30 may be a potent inhibitory protein against oxidative stress and chronic inflammation.
Title: Anti-inflammatory activity of SMP30 modulates NF-?B through protein tyrosine kinase/phosphatase balance.
The following Rgn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rgn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu16160 | |
Clone ID Related Accession (Same CDS sequence) | NM_009060.2 , XM_006527572.2 , XM_006527572.3 | |
Accession Version | NM_009060.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | regucalcin | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AL672073.8. On Nov 17, 2006 this sequence version replaced NM_009060.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U28937.1, AK146465.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849383 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTCTTCCA TCAAAGTTGA ATGTGTTTTA CGGGAGAACT ACAGGTGTGG GGAGTCTCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_033086.1 |
CDS | 73..972 |
Translation |
Target ORF information:
Target ORF information:
|
NM_009060.2 |
1 | ATGTCTTCCA TCAAAGTTGA ATGTGTTTTA CGGGAGAACT ACAGGTGTGG GGAGTCTCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu16160 | |
Clone ID Related Accession (Same CDS sequence) | NM_009060.2 , XM_006527572.2 , XM_006527572.3 | |
Accession Version | XM_006527572.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-02-08 | |
Organism | Mus musculus(House mouse) | |
Product | regucalcin isoform X1 | |
Comment |
1 | ATGTCTTCCA TCAAAGTTGA ATGTGTTTTA CGGGAGAACT ACAGGTGTGG GGAGTCTCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006527635.1 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006527572.2 |
1 | ATGTCTTCCA TCAAAGTTGA ATGTGTTTTA CGGGAGAACT ACAGGTGTGG GGAGTCTCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu16160 | |
Clone ID Related Accession (Same CDS sequence) | NM_009060.2 , XM_006527572.2 , XM_006527572.3 | |
Accession Version | XM_006527572.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | regucalcin isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000086.7) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006527572.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCTTCCA TCAAAGTTGA ATGTGTTTTA CGGGAGAACT ACAGGTGTGG GGAGTCTCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006527635.1 |
CDS | 98..997 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006527572.3 |
1 | ATGTCTTCCA TCAAAGTTGA ATGTGTTTTA CGGGAGAACT ACAGGTGTGG GGAGTCTCCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Hydrogen-rich pure water prevents cigarette smoke-induced pulmonary emphysema in SMP30 knockout mice. |