Gene Symbol | Rom1 |
Entrez Gene ID | 19881 |
Full Name | rod outer segment membrane protein 1 |
Synonyms | M101156,Rgsc1156,Rom-1,Rosp1,Tspan23 |
General protein information |
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Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Rom1 cDNA ORF clone
Gene Symbol | Rom1 |
Entrez Gene ID | 19881 |
Full Name | rod outer segment membrane protein 1 |
Synonyms | M101156,Rgsc1156,Rom-1,Rosp1,Tspan23 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_009073.4 | NP_033099.3 | rod outer segment membrane protein 1 |
Rom1 converts Y141C-Prph2-associated pattern dystrophy to retinitis pigmentosa.
Conley SM, Stuck MW, Watson JN, Naash MI
Human molecular genetics26(3)509-518(2017 02)
Transgenic analysis of rds/peripherin N-glycosylation: effect on dimerization, interaction with rom1, and rescue of the rds null phenotype.
Kedzierski W, Bok D, Travis GH
Journal of neurochemistry72(1)430-8(1999 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
ablation of Rom1 results in the conversion of an MD/PD phenotype characterized by cone functional defects and the formation of abnormal Prph2/Rom1 complexes to an RP phenotype characterized by rod-dominant functional defects and reductions in total Prph2 protein. Thus one method by which ROM1 may act as a disease modifier is by contributing to the large variability in PRPH2-associated disease phenotype
Title: Rom1 converts Y141C-Prph2-associated pattern dystrophy to retinitis pigmentosa.
ROM1 overexpression leads to negative effects on cone outer segments ultrastructure and function.
Title: Overexpression of ROM-1 in the cone-dominant retina.
The results suggested that Trp182Arg mutant Rom1 causes a decrease in the levels of wild-type Prph2 and Rom1.
Title: A monogenic dominant mutation in Rom1 generated by N-ethyl-N-nitrosourea mutagenesis causes retinal degeneration in mice.
The following Rom1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rom1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu03463 | |
Clone ID Related Accession (Same CDS sequence) | NM_009073.4 | |
Accession Version | NM_009073.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1056bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | rod outer segment membrane protein 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK133529.1, BC014827.1 and AC129217.3. On Aug 27, 2009 this sequence version replaced NM_009073.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK133529.1, BC014827.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849389 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCGCCGG TGCTGCCCGT GGTGCTGCCC CTCCAACCCC GTATCCGTTT GGCACAGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_033099.3 |
CDS | 184..1239 |
Translation |
Target ORF information:
Target ORF information:
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NM_009073.4 |
1 | ATGGCGCCGG TGCTGCCCGT GGTGCTGCCC CTCCAACCCC GTATCCGTTT GGCACAGGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Rom1 converts Y141C-Prph2-associated pattern dystrophy to retinitis pigmentosa. |
Transgenic analysis of rds/peripherin N-glycosylation: effect on dimerization, interaction with rom1, and rescue of the rds null phenotype. |