Gene Symbol | Slpi |
Entrez Gene ID | 20568 |
Full Name | secretory leukocyte peptidase inhibitor |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Slpi cDNA ORF clone
Gene Symbol | Slpi |
Entrez Gene ID | 20568 |
Full Name | secretory leukocyte peptidase inhibitor |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_011414.3 | NP_035544.1 | antileukoproteinase precursor |
MIF-2/D-DT enhances proximal tubular cell regeneration through SLPI- and ATF4-dependent mechanisms.
Ochi A, Chen D, Schulte W, Leng L, Moeckel N, Piecychna M, Averdunk L, Stoppe C, Bucala R, Moeckel G
American journal of physiology. Renal physiology313(3)F767-F780(2017 Sep)
Secretory leukocyte protease inhibitor regulates human periodontal ligament cell production of pro-inflammatory cytokines.
Svensson D, Aidoukovitch A, Anders E, J?nsson D, Nebel D, Nilsson BO
Inflammation research : official journal of the European Histamine Research Society ... [et al.]66(9)823-831(2017 Sep)
Secretory leukocyte protease inhibitor gene deletion alters bleomycin-induced lung injury, but not development of pulmonary fibrosis.
Habgood AN, Tatler AL, Porte J, Wahl SM, Laurent GJ, John AE, Johnson SR, Jenkins G
Laboratory investigation; a journal of technical methods and pathology96(6)623-31(2016 Jun)
A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.
Kumar V, Bouameur JE, B?r J, Rice RH, Hornig-Do HT, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Vijayaraj P, Brazel CB, Heller S, Binder H, L?ffler-Wirth H, Seibel P, Magin TM
The Journal of cell biology211(5)1057-75(2015 Dec)
Function of Secretory Leukocyte Protease Inhibitor (SLPI) in Odontoblast During Mouse Tooth Development.
Jeong JO, Wang G, Jeong SJ, Choi BD, Lee HY, Jeong MJ
Journal of nanoscience and nanotechnology15(1)120-4(2015 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
MIF-2/D-DT is an early response cytokine in the I/R injury repair of the proximal tubule, enhancing regeneration through SLPI- and ATF4-dependent mechanisms.
Title: MIF-2/D-DT enhances proximal tubular cell regeneration through SLPI- and ATF4-dependent mechanisms.
Slpi(-/-) mice had impaired collagen gene expression but animals demonstrated minimal reduction in lung fibrosis compared with wild-type animals. These data suggest that enhanced proteolysis does not further enhance TGF-beta activation, and inhibits sustained Col1alpha1, Col3alpha1, and Col4alpha1 gene expression following lung injury.
Title: Secretory leukocyte protease inhibitor gene deletion alters bleomycin-induced lung injury, but not development of pulmonary fibrosis.
Data show that differentiative switches between bronchiolar progenitors and club cells are under the Nrf2-mediated control of SLPI and syndecan 4.
Title: Syndecan 4 Mediates Nrf2-dependent Expansion of Bronchiolar Progenitors That Protect Against Lung Inflammation.
study identifies a distinct immune response in SA characterized by a dysregulated IFN-gamma/SLPI axis that affects lung function.
Title: High IFN-? and low SLPI mark severe asthma in mice and humans.
Studied the function of Secretory Leukocyte Protease Inhibitor (SLPI) in odontoblast during mouse tooth development.
Title: Function of Secretory Leukocyte Protease Inhibitor (SLPI) in Odontoblast During Mouse Tooth Development.
The following Slpi gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slpi cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu22721 | |
Clone ID Related Accession (Same CDS sequence) | NM_011414.3 | |
Accession Version | NM_011414.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 396bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-23 | |
Organism | Mus musculus(house mouse) | |
Product | antileukoproteinase precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC028509.1. On Apr 23, 2009 this sequence version replaced NM_011414.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC028509.1, CB575289.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164143 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAAGTCCT GCGGCCTTTT ACCTTTCACG GTGCTCCTTG CTCTGGGGAT CCTGGCACCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_035544.1 |
CDS | 236..631 |
Translation |
Target ORF information:
Target ORF information:
|
NM_011414.3 |
1 | ATGAAGTCCT GCGGCCTTTT ACCTTTCACG GTGCTCCTTG CTCTGGGGAT CCTGGCACCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
MIF-2/D-DT enhances proximal tubular cell regeneration through SLPI- and ATF4-dependent mechanisms. |
Secretory leukocyte protease inhibitor regulates human periodontal ligament cell production of pro-inflammatory cytokines. |
Secretory leukocyte protease inhibitor gene deletion alters bleomycin-induced lung injury, but not development of pulmonary fibrosis. |
A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity. |
Function of Secretory Leukocyte Protease Inhibitor (SLPI) in Odontoblast During Mouse Tooth Development. |