Spop cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Spop
Entrez Gene ID	20747
Full Name	speckle-type POZ protein
Synonyms	AI315626,Pcif1,TEF2
General protein information	Preferred Names speckle-type POZ protein Names speckle-type POZ protein HIB homolog 1 PDX-1 C-terminal-interacting factor 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 11 Map Location: 11 D\|11 59.01 cM

mRNA and Protein(s)

mRNA	Protein	Name
XM_006532692.1	XP_006532755.1	speckle-type POZ protein isoform X1
XM_006532692.2	XP_006532755.1	speckle-type POZ protein isoform X1
NM_025287.2	NP_079563.2	speckle-type POZ protein
NM_001359107.1	NP_001346036.1	speckle-type POZ protein

Pathways from BioSystems

Homologies

	SPOP	XP_002800447.1
Canis lupus familiaris (dog)	SPOP	XP_005624685.1
Mus musculus (house mouse)	Spop	NP_079563.2
Gallus gallus (chicken)	SPOP	XP_423281.2
Arabidopsis thaliana (thale cress)	BPM4	NP_566212.2
Homo sapiens (human)	SPOP	NP_001007229.1
Pan troglodytes (chimpanzee)	SPOP	XP_001168026.1
Rattus norvegicus (Norway rat)	Spop	NP_001093966.1
Bos taurus (cattle)	SPOP	NP_001069404.1
Danio rerio (zebrafish)	spop	NP_957424.1
Drosophila melanogaster (fruit fly)	rdx	NP_650325.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP003428	XP_311713.5
Oryza sativa (rice)	Os03g0792500	NP_001051524.1
Caenorhabditis elegans (roundworm)	bath-43	NP_001022765.1
Oryza sativa (rice)	Os07g0167200	NP_001058976.1
Xenopus tropicalis (tropical clawed frog)	spop	NP_989003.1

Gene Ontology
Bibliography

Related articles in PubMed

SPOP mutation drives prostate neoplasia without stabilizing oncogenic transcription factor ERG.
Shoag J, Liu D, Blattner M, Sboner A, Park K, Deonarine L, Robinson BD, Mosquera JM, Chen Y, Rubin MA, Barbieri CE
The Journal of clinical investigation128(1)381-386(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results demonstrate a negative role of Spop in the level and activity of Gli3, Shh signaling and ventral spinal cord patterning.
Title: Spop regulates Gli3 activity and Shh signaling in dorsoventral patterning of the mouse spinal cord.

Speckle-type pox virus and zinc finger (POZ) protein (SPOP) regulates endometrial stromal cell decidualization in mice and that hormones regulate the expression of SPOP. This study suggests that ubiquitination may be involved in embryonic implantation.
Title: SPOP Regulates Endometrial Stromal Cell Decidualization in Mice.

These results implicate SPOP as a novel participant in DNA double strand break repair and suggest that SPOP mutation drives prostate tumorigenesis in part through genomic instability.
Title: SPOP mutation leads to genomic instability in prostate cancer.

miR-145 has a role in post-transcriptional regulation of SPOP expression in selected tissues.
Title: Differential expression of speckled POZ protein, SPOP: putative regulation by miR-145.

Dzip1-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli/Ci proteins in the Hh pathway.
Title: Stabilization of speckle-type POZ protein (Spop) by Daz interacting protein 1 (Dzip1) is essential for Gli turnover and the proper output of Hedgehog signaling.

The following Spop gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Spop cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu20745	NM_025287.2 Latest version!	Mus musculus speckle-type BTB/POZ protein (Spop), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OMu20745	NM_001359107.1 Latest version!	Mus musculus speckle-type BTB/POZ protein (Spop), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OMu20745	XM_006532692.2 Latest version!	Mus musculus speckle-type POZ protein (Spop), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
View Old Accession Versions >>
OMu20745	XM_006532692.1	Mus musculus speckle-type POZ protein (Spop), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Spop ( NM_025287.2 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_079563.2 Mus musculus speckle-type BTB/POZ protein (Spop), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu20745
Clone ID Related Accession (Same CDS sequence)	XM_006532692.1 , XM_006532692.2 , NM_025287.2 , NM_001359107.1
Accession Version	NM_025287.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1125bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-16
Organism	Mus musculus(house mouse)
Product	speckle-type POZ protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY303667.1, BY726358.1, AK004669.1, AB071989.1 and CJ207806.1. On Nov 16, 2006 this sequence version replaced NM_025287.1. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK004669.1, SRR1660811.224142.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END##

ATGTCAAGGG TTCCAAGTCC TCCACCTCCG GCAGAAATGT CGAGTGGTCC CGTTGCCGAG 
AGCTGGTGCT ATACACAGAT CAAGGTAGTG AAGTTCTCCT ACATGTGGAC CATCAATAAC 
TTTAGTTTTT GCCGGGAGGA AATGGGTGAA GTCATAAAAA GTTCAACTTT TTCATCAGGA 
GCCAATGATA AACTGAAATG GTGTTTGCGA GTAAACCCGA AAGGGCTAGA TGAAGAAAGC 
AAAGATTACC TGTCGCTTTA CCTGTTGTTG GTCAGCTGTC CAAAGAGTGA AGTTCGGGCA 
AAGTTCAAGT TCTCCATCCT GAATGCCAAG GGAGAAGAAA CCAAAGCTAT GGAGAGTCAG 
CGAGCTTATA GGTTCGTGCA AGGCAAAGAC TGGGGATTCA AAAAATTCAT CCGCAGAGAT 
TTTCTCTTGG ACGAGGCCAA TGGGCTTCTC CCTGATGACA AGCTCACCCT CTTCTGTGAG 
GTGAGTGTAG TACAAGACTC TGTCAATATT TCTGGGCAGA ATACTATGAA CATGGTAAAG 
GTTCCTGAAT GCCGGTTGGC AGATGAGTTA GGAGGGCTGT GGGAGAACTC TCGATTCACC 
GACTGCTGCT TGTGTGTGGC TGGTCAAGAA TTCCAGGCTC ACAAGGCTAT CTTAGCAGCT 
CGGTCTCCAG TCTTCAGTGC CATGTTTGAA CATGAAATGG AGGAGAGCAA AAAGAATCGG 
GTTGAGATTA ACGACGTGGA GCCTGAGGTG TTTAAGGAGA TGATGTGCTT CATCTACACG 
GGGAAGGCGC CGAACCTCGA CAAGATGGCT GACGACTTGC TGGCAGCTGC CGATAAGTAC 
GCCCTGGAGC GTCTGAAGGT CATGTGTGAG GACGCCCTCT GCAGTAACCT CTCTGTGGAG 
AACGCTGCAG AGATTCTCAT CCTGGCTGAC CTCCACAGCG CAGATCAGCT GAAGACGCAG 
GCAGTTGATT TCATCAACTA TCATGCTTCG GATGTCTTGG AGACCTCTGG GTGGAAGTCA 
ATGGTGGTGT CACATCCCCA CTTAGTGGCA GAAGCATACC GTTCTCTGGC TTCAGCACAG 
TGCCCTTTCC TGGGGCCCCC ACGCAAACGC CTGAAGCAAT CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_079563.2
CDS	189..1313
Translation	MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS

Target ORF information:

RefSeq Version	NM_025287.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus speckle-type BTB/POZ protein (Spop), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_025287.2

ORF Insert Sequence:

ATGTCAAGGG TTCCAAGTCC TCCACCTCCG GCAGAAATGT CGAGTGGTCC CGTTGCCGAG 
AGCTGGTGCT ATACACAGAT CAAGGTAGTG AAGTTCTCCT ACATGTGGAC CATCAATAAC 
TTTAGTTTTT GCCGGGAGGA AATGGGTGAA GTCATAAAAA GTTCAACTTT TTCATCAGGA 
GCCAATGATA AACTGAAATG GTGTTTGCGA GTAAACCCGA AAGGGCTAGA TGAAGAAAGC 
AAAGATTACC TGTCGCTTTA CCTGTTGTTG GTCAGCTGTC CAAAGAGTGA AGTTCGGGCA 
AAGTTCAAGT TCTCCATCCT GAATGCCAAG GGAGAAGAAA CCAAAGCTAT GGAGAGTCAG 
CGAGCTTATA GGTTCGTGCA AGGCAAAGAC TGGGGATTCA AAAAATTCAT CCGCAGAGAT 
TTTCTCTTGG ACGAGGCCAA TGGGCTTCTC CCTGATGACA AGCTCACCCT CTTCTGTGAG 
GTGAGTGTAG TACAAGACTC TGTCAATATT TCTGGGCAGA ATACTATGAA CATGGTAAAG 
GTTCCTGAAT GCCGGTTGGC AGATGAGTTA GGAGGGCTGT GGGAGAACTC TCGATTCACC 
GACTGCTGCT TGTGTGTGGC TGGTCAAGAA TTCCAGGCTC ACAAGGCTAT CTTAGCAGCT 
CGGTCTCCAG TCTTCAGTGC CATGTTTGAA CATGAAATGG AGGAGAGCAA AAAGAATCGG 
GTTGAGATTA ACGACGTGGA GCCTGAGGTG TTTAAGGAGA TGATGTGCTT CATCTACACG 
GGGAAGGCGC CGAACCTCGA CAAGATGGCT GACGACTTGC TGGCAGCTGC CGATAAGTAC 
GCCCTGGAGC GTCTGAAGGT CATGTGTGAG GACGCCCTCT GCAGTAACCT CTCTGTGGAG 
AACGCTGCAG AGATTCTCAT CCTGGCTGAC CTCCACAGCG CAGATCAGCT GAAGACGCAG 
GCAGTTGATT TCATCAACTA TCATGCTTCG GATGTCTTGG AGACCTCTGG GTGGAAGTCA 
ATGGTGGTGT CACATCCCCA CTTAGTGGCA GAAGCATACC GTTCTCTGGC TTCAGCACAG 
TGCCCTTTCC TGGGGCCCCC ACGCAAACGC CTGAAGCAAT CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Spop ( NM_001359107.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001346036.1 Mus musculus speckle-type BTB/POZ protein (Spop), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OMu20745
Clone ID Related Accession (Same CDS sequence)	XM_006532692.1 , XM_006532692.2 , NM_025287.2 , NM_001359107.1
Accession Version	NM_001359107.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1125bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-16
Organism	Mus musculus(house mouse)
Product	speckle-type POZ protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY172312.1, AK132383.1 and BF662657.1. Transcript Variant: This variant (2) uses alternate splice sites in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849376 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCAAGGG TTCCAAGTCC TCCACCTCCG GCAGAAATGT CGAGTGGTCC CGTTGCCGAG 
AGCTGGTGCT ATACACAGAT CAAGGTAGTG AAGTTCTCCT ACATGTGGAC CATCAATAAC 
TTTAGTTTTT GCCGGGAGGA AATGGGTGAA GTCATAAAAA GTTCAACTTT TTCATCAGGA 
GCCAATGATA AACTGAAATG GTGTTTGCGA GTAAACCCGA AAGGGCTAGA TGAAGAAAGC 
AAAGATTACC TGTCGCTTTA CCTGTTGTTG GTCAGCTGTC CAAAGAGTGA AGTTCGGGCA 
AAGTTCAAGT TCTCCATCCT GAATGCCAAG GGAGAAGAAA CCAAAGCTAT GGAGAGTCAG 
CGAGCTTATA GGTTCGTGCA AGGCAAAGAC TGGGGATTCA AAAAATTCAT CCGCAGAGAT 
TTTCTCTTGG ACGAGGCCAA TGGGCTTCTC CCTGATGACA AGCTCACCCT CTTCTGTGAG 
GTGAGTGTAG TACAAGACTC TGTCAATATT TCTGGGCAGA ATACTATGAA CATGGTAAAG 
GTTCCTGAAT GCCGGTTGGC AGATGAGTTA GGAGGGCTGT GGGAGAACTC TCGATTCACC 
GACTGCTGCT TGTGTGTGGC TGGTCAAGAA TTCCAGGCTC ACAAGGCTAT CTTAGCAGCT 
CGGTCTCCAG TCTTCAGTGC CATGTTTGAA CATGAAATGG AGGAGAGCAA AAAGAATCGG 
GTTGAGATTA ACGACGTGGA GCCTGAGGTG TTTAAGGAGA TGATGTGCTT CATCTACACG 
GGGAAGGCGC CGAACCTCGA CAAGATGGCT GACGACTTGC TGGCAGCTGC CGATAAGTAC 
GCCCTGGAGC GTCTGAAGGT CATGTGTGAG GACGCCCTCT GCAGTAACCT CTCTGTGGAG 
AACGCTGCAG AGATTCTCAT CCTGGCTGAC CTCCACAGCG CAGATCAGCT GAAGACGCAG 
GCAGTTGATT TCATCAACTA TCATGCTTCG GATGTCTTGG AGACCTCTGG GTGGAAGTCA 
ATGGTGGTGT CACATCCCCA CTTAGTGGCA GAAGCATACC GTTCTCTGGC TTCAGCACAG 
TGCCCTTTCC TGGGGCCCCC ACGCAAACGC CTGAAGCAAT CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001346036.1
CDS	389..1513
Translation	MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS

Target ORF information:

RefSeq Version	NM_001359107.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus speckle-type BTB/POZ protein (Spop), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001359107.1

ORF Insert Sequence:

ATGTCAAGGG TTCCAAGTCC TCCACCTCCG GCAGAAATGT CGAGTGGTCC CGTTGCCGAG 
AGCTGGTGCT ATACACAGAT CAAGGTAGTG AAGTTCTCCT ACATGTGGAC CATCAATAAC 
TTTAGTTTTT GCCGGGAGGA AATGGGTGAA GTCATAAAAA GTTCAACTTT TTCATCAGGA 
GCCAATGATA AACTGAAATG GTGTTTGCGA GTAAACCCGA AAGGGCTAGA TGAAGAAAGC 
AAAGATTACC TGTCGCTTTA CCTGTTGTTG GTCAGCTGTC CAAAGAGTGA AGTTCGGGCA 
AAGTTCAAGT TCTCCATCCT GAATGCCAAG GGAGAAGAAA CCAAAGCTAT GGAGAGTCAG 
CGAGCTTATA GGTTCGTGCA AGGCAAAGAC TGGGGATTCA AAAAATTCAT CCGCAGAGAT 
TTTCTCTTGG ACGAGGCCAA TGGGCTTCTC CCTGATGACA AGCTCACCCT CTTCTGTGAG 
GTGAGTGTAG TACAAGACTC TGTCAATATT TCTGGGCAGA ATACTATGAA CATGGTAAAG 
GTTCCTGAAT GCCGGTTGGC AGATGAGTTA GGAGGGCTGT GGGAGAACTC TCGATTCACC 
GACTGCTGCT TGTGTGTGGC TGGTCAAGAA TTCCAGGCTC ACAAGGCTAT CTTAGCAGCT 
CGGTCTCCAG TCTTCAGTGC CATGTTTGAA CATGAAATGG AGGAGAGCAA AAAGAATCGG 
GTTGAGATTA ACGACGTGGA GCCTGAGGTG TTTAAGGAGA TGATGTGCTT CATCTACACG 
GGGAAGGCGC CGAACCTCGA CAAGATGGCT GACGACTTGC TGGCAGCTGC CGATAAGTAC 
GCCCTGGAGC GTCTGAAGGT CATGTGTGAG GACGCCCTCT GCAGTAACCT CTCTGTGGAG 
AACGCTGCAG AGATTCTCAT CCTGGCTGAC CTCCACAGCG CAGATCAGCT GAAGACGCAG 
GCAGTTGATT TCATCAACTA TCATGCTTCG GATGTCTTGG AGACCTCTGG GTGGAAGTCA 
ATGGTGGTGT CACATCCCCA CTTAGTGGCA GAAGCATACC GTTCTCTGGC TTCAGCACAG 
TGCCCTTTCC TGGGGCCCCC ACGCAAACGC CTGAAGCAAT CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Spop ( XM_006532692.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006532755.1 Mus musculus speckle-type POZ protein (Spop), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu20745
Clone ID Related Accession (Same CDS sequence)	XM_006532692.1 , XM_006532692.2 , NM_025287.2 , NM_001359107.1
Accession Version	XM_006532692.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1125bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-08
Organism	Mus musculus(House mouse)
Product	speckle-type POZ protein isoform X1
Comment

ATGTCAAGGG TTCCAAGTCC TCCACCTCCG GCAGAAATGT CGAGTGGTCC CGTTGCCGAG 
AGCTGGTGCT ATACACAGAT CAAGGTAGTG AAGTTCTCCT ACATGTGGAC CATCAATAAC 
TTTAGTTTTT GCCGGGAGGA AATGGGTGAA GTCATAAAAA GTTCAACTTT TTCATCAGGA 
GCCAATGATA AACTGAAATG GTGTTTGCGA GTAAACCCGA AAGGGCTAGA TGAAGAAAGC 
AAAGATTACC TGTCGCTTTA CCTGTTGTTG GTCAGCTGTC CAAAGAGTGA AGTTCGGGCA 
AAGTTCAAGT TCTCCATCCT GAATGCCAAG GGAGAAGAAA CCAAAGCTAT GGAGAGTCAG 
CGAGCTTATA GGTTCGTGCA AGGCAAAGAC TGGGGATTCA AAAAATTCAT CCGCAGAGAT 
TTTCTCTTGG ACGAGGCCAA TGGGCTTCTC CCTGATGACA AGCTCACCCT CTTCTGTGAG 
GTGAGTGTAG TACAAGACTC TGTCAATATT TCTGGGCAGA ATACTATGAA CATGGTAAAG 
GTTCCTGAAT GCCGGTTGGC AGATGAGTTA GGAGGGCTGT GGGAGAACTC TCGATTCACC 
GACTGCTGCT TGTGTGTGGC TGGTCAAGAA TTCCAGGCTC ACAAGGCTAT CTTAGCAGCT 
CGGTCTCCAG TCTTCAGTGC CATGTTTGAA CATGAAATGG AGGAGAGCAA AAAGAATCGG 
GTTGAGATTA ACGACGTGGA GCCTGAGGTG TTTAAGGAGA TGATGTGCTT CATCTACACG 
GGGAAGGCGC CGAACCTCGA CAAGATGGCT GACGACTTGC TGGCAGCTGC CGATAAGTAC 
GCCCTGGAGC GTCTGAAGGT CATGTGTGAG GACGCCCTCT GCAGTAACCT CTCTGTGGAG 
AACGCTGCAG AGATTCTCAT CCTGGCTGAC CTCCACAGCG CAGATCAGCT GAAGACGCAG 
GCAGTTGATT TCATCAACTA TCATGCTTCG GATGTCTTGG AGACCTCTGG GTGGAAGTCA 
ATGGTGGTGT CACATCCCCA CTTAGTGGCA GAAGCATACC GTTCTCTGGC TTCAGCACAG 
TGCCCTTTCC TGGGGCCCCC ACGCAAACGC CTGAAGCAAT CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006532755.1
Translation	MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS

Target ORF information:

RefSeq Version	XM_006532692.1
Organism	Mus musculus(House mouse)
Definition	Mus musculus speckle-type POZ protein (Spop), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006532692.1

ORF Insert Sequence:

ATGTCAAGGG TTCCAAGTCC TCCACCTCCG GCAGAAATGT CGAGTGGTCC CGTTGCCGAG 
AGCTGGTGCT ATACACAGAT CAAGGTAGTG AAGTTCTCCT ACATGTGGAC CATCAATAAC 
TTTAGTTTTT GCCGGGAGGA AATGGGTGAA GTCATAAAAA GTTCAACTTT TTCATCAGGA 
GCCAATGATA AACTGAAATG GTGTTTGCGA GTAAACCCGA AAGGGCTAGA TGAAGAAAGC 
AAAGATTACC TGTCGCTTTA CCTGTTGTTG GTCAGCTGTC CAAAGAGTGA AGTTCGGGCA 
AAGTTCAAGT TCTCCATCCT GAATGCCAAG GGAGAAGAAA CCAAAGCTAT GGAGAGTCAG 
CGAGCTTATA GGTTCGTGCA AGGCAAAGAC TGGGGATTCA AAAAATTCAT CCGCAGAGAT 
TTTCTCTTGG ACGAGGCCAA TGGGCTTCTC CCTGATGACA AGCTCACCCT CTTCTGTGAG 
GTGAGTGTAG TACAAGACTC TGTCAATATT TCTGGGCAGA ATACTATGAA CATGGTAAAG 
GTTCCTGAAT GCCGGTTGGC AGATGAGTTA GGAGGGCTGT GGGAGAACTC TCGATTCACC 
GACTGCTGCT TGTGTGTGGC TGGTCAAGAA TTCCAGGCTC ACAAGGCTAT CTTAGCAGCT 
CGGTCTCCAG TCTTCAGTGC CATGTTTGAA CATGAAATGG AGGAGAGCAA AAAGAATCGG 
GTTGAGATTA ACGACGTGGA GCCTGAGGTG TTTAAGGAGA TGATGTGCTT CATCTACACG 
GGGAAGGCGC CGAACCTCGA CAAGATGGCT GACGACTTGC TGGCAGCTGC CGATAAGTAC 
GCCCTGGAGC GTCTGAAGGT CATGTGTGAG GACGCCCTCT GCAGTAACCT CTCTGTGGAG 
AACGCTGCAG AGATTCTCAT CCTGGCTGAC CTCCACAGCG CAGATCAGCT GAAGACGCAG 
GCAGTTGATT TCATCAACTA TCATGCTTCG GATGTCTTGG AGACCTCTGG GTGGAAGTCA 
ATGGTGGTGT CACATCCCCA CTTAGTGGCA GAAGCATACC GTTCTCTGGC TTCAGCACAG 
TGCCCTTTCC TGGGGCCCCC ACGCAAACGC CTGAAGCAAT CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Spop ( XM_006532692.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006532755.1 Mus musculus speckle-type POZ protein (Spop), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu20745
Clone ID Related Accession (Same CDS sequence)	XM_006532692.1 , XM_006532692.2 , NM_025287.2 , NM_001359107.1
Accession Version	XM_006532692.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1125bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	speckle-type POZ protein isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006532692.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCAAGGG TTCCAAGTCC TCCACCTCCG GCAGAAATGT CGAGTGGTCC CGTTGCCGAG 
AGCTGGTGCT ATACACAGAT CAAGGTAGTG AAGTTCTCCT ACATGTGGAC CATCAATAAC 
TTTAGTTTTT GCCGGGAGGA AATGGGTGAA GTCATAAAAA GTTCAACTTT TTCATCAGGA 
GCCAATGATA AACTGAAATG GTGTTTGCGA GTAAACCCGA AAGGGCTAGA TGAAGAAAGC 
AAAGATTACC TGTCGCTTTA CCTGTTGTTG GTCAGCTGTC CAAAGAGTGA AGTTCGGGCA 
AAGTTCAAGT TCTCCATCCT GAATGCCAAG GGAGAAGAAA CCAAAGCTAT GGAGAGTCAG 
CGAGCTTATA GGTTCGTGCA AGGCAAAGAC TGGGGATTCA AAAAATTCAT CCGCAGAGAT 
TTTCTCTTGG ACGAGGCCAA TGGGCTTCTC CCTGATGACA AGCTCACCCT CTTCTGTGAG 
GTGAGTGTAG TACAAGACTC TGTCAATATT TCTGGGCAGA ATACTATGAA CATGGTAAAG 
GTTCCTGAAT GCCGGTTGGC AGATGAGTTA GGAGGGCTGT GGGAGAACTC TCGATTCACC 
GACTGCTGCT TGTGTGTGGC TGGTCAAGAA TTCCAGGCTC ACAAGGCTAT CTTAGCAGCT 
CGGTCTCCAG TCTTCAGTGC CATGTTTGAA CATGAAATGG AGGAGAGCAA AAAGAATCGG 
GTTGAGATTA ACGACGTGGA GCCTGAGGTG TTTAAGGAGA TGATGTGCTT CATCTACACG 
GGGAAGGCGC CGAACCTCGA CAAGATGGCT GACGACTTGC TGGCAGCTGC CGATAAGTAC 
GCCCTGGAGC GTCTGAAGGT CATGTGTGAG GACGCCCTCT GCAGTAACCT CTCTGTGGAG 
AACGCTGCAG AGATTCTCAT CCTGGCTGAC CTCCACAGCG CAGATCAGCT GAAGACGCAG 
GCAGTTGATT TCATCAACTA TCATGCTTCG GATGTCTTGG AGACCTCTGG GTGGAAGTCA 
ATGGTGGTGT CACATCCCCA CTTAGTGGCA GAAGCATACC GTTCTCTGGC TTCAGCACAG 
TGCCCTTTCC TGGGGCCCCC ACGCAAACGC CTGAAGCAAT CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006532755.1
CDS	409..1533
Translation	MSRVPSPPPPAEMSSGPVAESWCYTQIKVVKFSYMWTINNFSFCREEMGEVIKSSTFSSGANDKLKWCLRVNPKGLDEESKDYLSLYLLLVSCPKSEVRAKFKFSILNAKGEETKAMESQRAYRFVQGKDWGFKKFIRRDFLLDEANGLLPDDKLTLFCEVSVVQDSVNISGQNTMNMVKVPECRLADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPNLDKMADDLLAAADKYALERLKVMCEDALCSNLSVENAAEILILADLHSADQLKTQAVDFINYHASDVLETSGWKSMVVSHPHLVAEAYRSLASAQCPFLGPPRKRLKQS

Target ORF information:

RefSeq Version	XM_006532692.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus speckle-type POZ protein (Spop), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006532692.2

ORF Insert Sequence:

ATGTCAAGGG TTCCAAGTCC TCCACCTCCG GCAGAAATGT CGAGTGGTCC CGTTGCCGAG 
AGCTGGTGCT ATACACAGAT CAAGGTAGTG AAGTTCTCCT ACATGTGGAC CATCAATAAC 
TTTAGTTTTT GCCGGGAGGA AATGGGTGAA GTCATAAAAA GTTCAACTTT TTCATCAGGA 
GCCAATGATA AACTGAAATG GTGTTTGCGA GTAAACCCGA AAGGGCTAGA TGAAGAAAGC 
AAAGATTACC TGTCGCTTTA CCTGTTGTTG GTCAGCTGTC CAAAGAGTGA AGTTCGGGCA 
AAGTTCAAGT TCTCCATCCT GAATGCCAAG GGAGAAGAAA CCAAAGCTAT GGAGAGTCAG 
CGAGCTTATA GGTTCGTGCA AGGCAAAGAC TGGGGATTCA AAAAATTCAT CCGCAGAGAT 
TTTCTCTTGG ACGAGGCCAA TGGGCTTCTC CCTGATGACA AGCTCACCCT CTTCTGTGAG 
GTGAGTGTAG TACAAGACTC TGTCAATATT TCTGGGCAGA ATACTATGAA CATGGTAAAG 
GTTCCTGAAT GCCGGTTGGC AGATGAGTTA GGAGGGCTGT GGGAGAACTC TCGATTCACC 
GACTGCTGCT TGTGTGTGGC TGGTCAAGAA TTCCAGGCTC ACAAGGCTAT CTTAGCAGCT 
CGGTCTCCAG TCTTCAGTGC CATGTTTGAA CATGAAATGG AGGAGAGCAA AAAGAATCGG 
GTTGAGATTA ACGACGTGGA GCCTGAGGTG TTTAAGGAGA TGATGTGCTT CATCTACACG 
GGGAAGGCGC CGAACCTCGA CAAGATGGCT GACGACTTGC TGGCAGCTGC CGATAAGTAC 
GCCCTGGAGC GTCTGAAGGT CATGTGTGAG GACGCCCTCT GCAGTAACCT CTCTGTGGAG 
AACGCTGCAG AGATTCTCAT CCTGGCTGAC CTCCACAGCG CAGATCAGCT GAAGACGCAG 
GCAGTTGATT TCATCAACTA TCATGCTTCG GATGTCTTGG AGACCTCTGG GTGGAAGTCA 
ATGGTGGTGT CACATCCCCA CTTAGTGGCA GAAGCATACC GTTCTCTGGC TTCAGCACAG 
TGCCCTTTCC TGGGGCCCCC ACGCAAACGC CTGAAGCAAT CCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

SPOP mutation drives prostate neoplasia without stabilizing oncogenic transcription factor ERG.
The Journal of clinical investigation128(1)381-386(2018 Jan)
Shoag J,Liu D,Blattner M,Sboner A,Park K,Deonarine L,Robinson BD,Mosquera JM,Chen Y,Rubin MA,Barbieri CE

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Spop cDNA ORF clone, Mus musculus(house mouse)

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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