Gene Symbol | Btla |
Entrez Gene ID | 208154 |
Full Name | B and T lymphocyte associated |
Synonyms | A630002H24 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Btla cDNA ORF clone
Gene Symbol | Btla |
Entrez Gene ID | 208154 |
Full Name | B and T lymphocyte associated |
Synonyms | A630002H24 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006521907.3 | XP_006521970.1 | B- and T-lymphocyte attenuator isoform X1 |
XM_006521909.3 | XP_006521972.1 | B- and T-lymphocyte attenuator isoform X3 |
XM_006521908.3 | XP_006521971.1 | B- and T-lymphocyte attenuator isoform X2 |
XM_006521907.4 | XP_006521970.1 | B- and T-lymphocyte attenuator isoform X1 |
XM_006521908.4 | XP_006521971.1 | B- and T-lymphocyte attenuator isoform X2 |
NM_001037719.2 | NP_001032808.2 | B- and T-lymphocyte attenuator isoform 1 precursor |
NM_177584.3 | NP_808252.1 | B- and T-lymphocyte attenuator isoform 2 precursor |
Mus musculus (house mouse) | Btla | NP_001032808.2 |
Xenopus tropicalis (tropical clawed frog) | LOC101732729 | XP_004912313.1 |
Canis lupus familiaris (dog) | BTLA | XP_005639537.1 |
BTLA | XP_001104281.1 | |
Bos taurus (cattle) | BTLA | XP_005201410.1 |
Rattus norvegicus (Norway rat) | Btla | NP_998795.1 |
Homo sapiens (human) | BTLA | NP_861445.3 |
Pan troglodytes (chimpanzee) | BTLA | XP_001154904.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100496917 | XP_002942680.1 |
Adenovirus-Mediated CCR7 and BTLA Overexpression Enhances Immune Tolerance and Migration in Immature Dendritic Cells.
Xin H, Zhu J, Miao H, Gong Z, Jiang X, Feng X, Tong Y
BioMed research international20173519745(2017)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
these data indicate that CCR7 and BTLA cooverexpression imparts an intermediate immune phenotype in mmature dendritic cells when compared to that in CCR7- or BTLA-expressing counterparts that show a more immunocompetent or immunotolerant phenotype
Title: Adenovirus-Mediated CCR7 and BTLA Overexpression Enhances Immune Tolerance and Migration in Immature Dendritic Cells.
The percentage of circulating BTLA+CD4+ lymphocytes was significantly higher in mice with LPS-induced acute lung inflammation.
Title: Expression of B and T Lymphocyte Attenuator in Patients with Severe Community-Acquired Pneumonia and the Effect of Steroid Therapy in a Mouse Model.
Dendritic cells require BTLA and HVEM to actively adjust tolerizing T cell responses under steady-state conditions.
Title: Immunomodulatory Functions of BTLA and HVEM Govern Induction of Extrathymic Regulatory T Cells and Tolerance by Dendritic Cells.
this study shows that miR-155 is involved in the inhibition of BTLA during CD4+ T cell activation
Title: B and T Lymphocyte Attenuator is a Target of miR-155 during Na?ve CD4+ T Cell Activation.
Our findings indicate that BTLA may be involved in the control of inflammatory responses through increasing Foxp3 expression, rather than attenuating IL-17 production, in dextran sulfate sodium-induced colitis.
Title: BTLA associates with increased Foxp3 expression in CD4(+) T cells in dextran sulfate sodium-induced colitis.
The following Btla gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Btla cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu17924 | |
Clone ID Related Accession (Same CDS sequence) | NM_177584.3 | |
Accession Version | NM_177584.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 918bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Mus musculus(house mouse) | |
Product | B- and T-lymphocyte attenuator isoform 2 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK041334.1 and BB123968.1. On Dec 16, 2005 this sequence version replaced NM_177584.2. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform 2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK041334.1, SRR1660819.87184.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAAGACAG TGCCTGCCAT GCTTGGGACT CCTCGGTTAT TTAGGGAATT CTTCATCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_808252.1 |
CDS | 17..934 |
Translation |
Target ORF information:
Target ORF information:
|
NM_177584.3 |
1 | ATGAAGACAG TGCCTGCCAT GCTTGGGACT CCTCGGTTAT TTAGGGAATT CTTCATCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu51961 | |
Clone ID Related Accession (Same CDS sequence) | XM_006521907.3 , XM_006521907.4 | |
Accession Version | XM_006521907.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | B- and T-lymphocyte attenuator isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006521907.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGACAG TGCCTGCCAT GCTTGGGACT CCTCGGTTAT TTAGGGAATT CTTCATCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006521970.1 |
CDS | 662..1261 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006521907.3 |
1 | ATGAAGACAG TGCCTGCCAT GCTTGGGACT CCTCGGTTAT TTAGGGAATT CTTCATCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu51962 | |
Clone ID Related Accession (Same CDS sequence) | XM_006521908.3 , XM_006521908.4 | |
Accession Version | XM_006521908.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | B- and T-lymphocyte attenuator isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006521908.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGACAG TGCCTGCCAT GCTTGGGACT CCTCGGTTAT TTAGGGAATT CTTCATCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006521971.1 |
CDS | 662..1258 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006521908.3 |
1 | ATGAAGACAG TGCCTGCCAT GCTTGGGACT CCTCGGTTAT TTAGGGAATT CTTCATCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu51963 | |
Clone ID Related Accession (Same CDS sequence) | XM_006521909.3 | |
Accession Version | XM_006521909.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 495bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | B- and T-lymphocyte attenuator isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006521909.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGACAG TGCCTGCCAT GCTTGGGACT CCTCGGTTAT TTAGGGAATT CTTCATCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006521972.1 |
CDS | 809..1303 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006521909.3 |
1 | ATGAAGACAG TGCCTGCCAT GCTTGGGACT CCTCGGTTAT TTAGGGAATT CTTCATCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu17940 | |
Clone ID Related Accession (Same CDS sequence) | NM_001037719.2 | |
Accession Version | NM_001037719.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 921bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-24 | |
Organism | Mus musculus(house mouse) | |
Product | B- and T-lymphocyte attenuator isoform 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK041334.1, BC108964.1 and BB123968.1. On Dec 16, 2005 this sequence version replaced NM_001037719.1. Transcript Variant: This variant (1) encodes the longer transcript and it encodes the longer protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC108964.1, AY293285.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAAGACAG TGCCTGCCAT GCTTGGGACT CCTCGGTTAT TTAGGGAATT CTTCATCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001032808.2 |
CDS | 17..937 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001037719.2 |
1 | ATGAAGACAG TGCCTGCCAT GCTTGGGACT CCTCGGTTAT TTAGGGAATT CTTCATCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu51961 | |
Clone ID Related Accession (Same CDS sequence) | XM_006521907.3 , XM_006521907.4 | |
Accession Version | XM_006521907.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 600bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | B- and T-lymphocyte attenuator isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006521907.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGACAG TGCCTGCCAT GCTTGGGACT CCTCGGTTAT TTAGGGAATT CTTCATCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006521970.1 |
CDS | 649..1248 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006521907.4 |
1 | ATGAAGACAG TGCCTGCCAT GCTTGGGACT CCTCGGTTAT TTAGGGAATT CTTCATCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu51962 | |
Clone ID Related Accession (Same CDS sequence) | XM_006521908.3 , XM_006521908.4 | |
Accession Version | XM_006521908.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 597bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | B- and T-lymphocyte attenuator isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000082.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006521908.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGACAG TGCCTGCCAT GCTTGGGACT CCTCGGTTAT TTAGGGAATT CTTCATCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006521971.1 |
CDS | 649..1245 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006521908.4 |
1 | ATGAAGACAG TGCCTGCCAT GCTTGGGACT CCTCGGTTAT TTAGGGAATT CTTCATCCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Adenovirus-Mediated CCR7 and BTLA Overexpression Enhances Immune Tolerance and Migration in Immature Dendritic Cells. |