Hk3 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Hk3 |
| Entrez Gene ID | 212032 |
| Full Name | hexokinase 3 |
| Synonyms | HK III,HK-III |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001033245.4 | NP_001028417.1 | hexokinase-3 isoform 1 |
| XM_006517193.3 | XP_006517256.1 | hexokinase-3 isoform X1 |
| NM_001206392.1 | NP_001193321.1 | hexokinase-3 isoform 3 |
| NM_001206391.1 | NP_001193320.1 | hexokinase-3 isoform 2 |
| NM_001206390.1 | NP_001193319.1 | hexokinase-3 isoform 1 |
| XM_006517193.4 | XP_006517256.1 | hexokinase-3 isoform X1 |
| Pan troglodytes (chimpanzee) | HK3 | XP_518124.2 |
| HK3 | XP_001086179.1 | |
| Mus musculus (house mouse) | Hk3 | NP_001028417.1 |
| Gallus gallus (chicken) | HK3 | XP_001231329.3 |
| Homo sapiens (human) | HK3 | NP_002106.2 |
| Canis lupus familiaris (dog) | HK3 | XP_546212.4 |
| Rattus norvegicus (Norway rat) | Hk3 | NP_071515.1 |
Related articles in PubMed
Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development.
Bulusu V, Prior N, Snaebjornsson MT, Kuehne A, Sonnen KF, Kress J, Stein F, Schultz C, Sauer U, Aulehla A
Developmental cell40(4)331-341.e4(2017 02)
Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series.
Bowman CE, Zhao L, Hartung T, Wolfgang MJ
Molecular and cellular biology36(15)2089-104(2016 Aug)
Chronic Activation of ?2 AMPK Induces Obesity and Reduces ? Cell Function.
Yavari A, Stocker CJ, Ghaffari S, Wargent ET, Steeples V, Czibik G, Pinter K, Bellahcene M, Woods A, Mart?nez de Morentin PB, Cansell C, Lam BY, Chuster A, Petkevicius K, Nguyen-Tu MS, Martinez-Sanchez A, Pullen TJ, Oliver PL, Stockenhuber A, Nguyen C, Lazdam M, O'Dowd JF, Harikumar P, T?th M, Beall C, Kyriakou T, Parnis J, Sarma D, Katritsis G, Wortmann DD, Harper AR, Brown LA, Willows R, Gandra S, Poncio V, de Oliveira Figueiredo MJ, Qi NR, Peirson SN, McCrimmon RJ, Gereben B, Tretter L, Fekete C, Redwood C, Yeo GS, Heisler LK, Rutter GA, Smith MA, Withers DJ, Carling D, Sternick EB, Arch JR, Cawthorne MA, Watkins H, Ashrafian H
Cell metabolism23(5)821-36(2016 May)
Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism.
Lundgaard I, Li B, Xie L, Kang H, Sanggaard S, Haswell JD, Sun W, Goldman S, Blekot S, Nielsen M, Takano T, Deane R, Nedergaard M
Nature communications66807(2015 Apr)
Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice.
Leite TC, Coelho RG, Da Silva D, Coelho WS, Marinho-Carvalho MM, Sola-Penna M
FEBS letters585(1)92-8(2011 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Hexokinase expression is highly enriched in neurons compared to astrocytes.
Title: Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism.
The following Hk3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Hk3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu12866 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001206392.1 | |
| Accession Version | NM_001206392.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2604bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-03 | |
| Organism | Mus musculus(house mouse) | |
| Product | hexokinase-3 isoform 3 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC154610.3. Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AK159857.1, AK170813.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## | |
1 | ATGGAGCAGG CACTGAAGGG ACAGGACAGT CCCGCTCCTT CTGTCCGGAT GCTGCCCACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001193321.1 |
| CDS | 310..2913 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001206392.1 |
ORF Insert Sequence:
1 | ATGGAGCAGG CACTGAAGGG ACAGGACAGT CCCGCTCCTT CTGTCCGGAT GCTGCCCACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu12903 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001206391.1 | |
| Accession Version | NM_001206391.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2634bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-27 | |
| Organism | Mus musculus(house mouse) | |
| Product | hexokinase-3 isoform 2 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC154610.3. Transcript Variant: This variant (3) differs in the 5' UTR and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC117861.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## | |
1 | ATGGCCACCA TTGGGCCTTC TGGCCTGCAT CCTGGAGAAA GAGCCTCAGT CTGCCCACAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001193320.1 |
| CDS | 75..2708 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001206391.1 |
ORF Insert Sequence:
1 | ATGGCCACCA TTGGGCCTTC TGGCCTGCAT CCTGGAGAAA GAGCCTCAGT CTGCCCACAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu12949 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001033245.4 , NM_001206390.1 | |
| Accession Version | NM_001033245.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2769bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-03 | |
| Organism | Mus musculus(house mouse) | |
| Product | hexokinase-3 isoform 1 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC154610.3, AK171580.1 and BI133441.1. On Apr 22, 2011 this sequence version replaced NM_001033245.3. Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK171580.1, AK154603.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## | |
1 | ATGGCCACCA TTGGGCCTTC TGGCCTGCAT CCTGGAGAAA GAGCCTCAGT CTGCCCACAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001028417.1 |
| CDS | 265..3033 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001033245.4 |
ORF Insert Sequence:
1 | ATGGCCACCA TTGGGCCTTC TGGCCTGCAT CCTGGAGAAA GAGCCTCAGT CTGCCCACAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu12949 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001033245.4 , NM_001206390.1 | |
| Accession Version | NM_001206390.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2769bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-03 | |
| Organism | Mus musculus(house mouse) | |
| Product | hexokinase-3 isoform 1 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC154610.3. Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (1). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC117860.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## | |
1 | ATGGCCACCA TTGGGCCTTC TGGCCTGCAT CCTGGAGAAA GAGCCTCAGT CTGCCCACAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001193319.1 |
| CDS | 75..2843 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001206390.1 |
ORF Insert Sequence:
1 | ATGGCCACCA TTGGGCCTTC TGGCCTGCAT CCTGGAGAAA GAGCCTCAGT CTGCCCACAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu48717 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006517193.3 , XM_006517193.4 | |
| Accession Version | XM_006517193.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2676bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2016-06-21 | |
| Organism | Mus musculus(house mouse) | |
| Product | hexokinase-3 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000079.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006517193.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGAATGCT TGCAGCAATT CAAGGTGACC AGGACACAGT TGCAGCAGAT CCAAGCCAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006517256.1 |
| CDS | 541..3216 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_006517193.3 |
ORF Insert Sequence:
1 | ATGGAATGCT TGCAGCAATT CAAGGTGACC AGGACACAGT TGCAGCAGAT CCAAGCCAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu48717 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006517193.3 , XM_006517193.4 | |
| Accession Version | XM_006517193.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2676bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-07 | |
| Organism | Mus musculus(house mouse) | |
| Product | hexokinase-3 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000079.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006517193.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGAATGCT TGCAGCAATT CAAGGTGACC AGGACACAGT TGCAGCAGAT CCAAGCCAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006517256.1 |
| CDS | 540..3215 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_006517193.4 |
ORF Insert Sequence:
1 | ATGGAATGCT TGCAGCAATT CAAGGTGACC AGGACACAGT TGCAGCAGAT CCAAGCCAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. |
|
Requirement for the Mitochondrial Pyruvate Carrier in Mammalian Development Revealed by a Hypomorphic Allelic Series. |
|
Chronic Activation of ?2 AMPK Induces Obesity and Reduces ? Cell Function. |
|
Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism. |
|
Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice. |