Gene Symbol | Cc2d1a |
Entrez Gene ID | 212139 |
Full Name | coiled-coil and C2 domain containing 1A |
Synonyms | BC016188,Freud-1,Tape |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Cc2d1a cDNA ORF clone
Gene Symbol | Cc2d1a |
Entrez Gene ID | 212139 |
Full Name | coiled-coil and C2 domain containing 1A |
Synonyms | BC016188,Freud-1,Tape |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006530810.2 | XP_006530873.1 | coiled-coil and C2 domain-containing protein 1A isoform X1 |
XM_006530810.3 | XP_006530873.1 | coiled-coil and C2 domain-containing protein 1A isoform X1 |
NM_145970.2 | NP_666082.2 | coiled-coil and C2 domain-containing protein 1A |
NM_145970.1 | NP_666082.2 | coiled-coil and C2 domain-containing protein 1A |
Pan troglodytes (chimpanzee) | CC2D1A | XP_524131.4 |
Xenopus tropicalis (tropical clawed frog) | cc2d1a | NP_001120385.1 |
Homo sapiens (human) | CC2D1A | NP_060191.3 |
Bos taurus (cattle) | CC2D1A | NP_001092424.1 |
Rattus norvegicus (Norway rat) | Cc2d1a | NP_001013891.1 |
Drosophila melanogaster (fruit fly) | l(2)gd1 | NP_001245976.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010539 | XP_314506.4 |
Caenorhabditis elegans (roundworm) | CELE_Y37H9A.3 | NP_493412.2 |
CC2D1A | XP_001111234.2 | |
Canis lupus familiaris (dog) | CC2D1A | XP_542027.3 |
Mus musculus (house mouse) | Cc2d1a | NP_666082.2 |
Abrogated Freud-1/Cc2d1a Repression of 5-HT1A Autoreceptors Induces Fluoxetine-Resistant Anxiety/Depression-Like Behavior.
Vahid-Ansari F, Daigle M, Manzini MC, Tanaka KF, Hen R, Geddes SD, B??que JC, James J, Merali Z, Albert PR
The Journal of neuroscience : the official journal of the Society for Neuroscience37(49)11967-11978(2017 Dec)
Cc2d1a Loss of Function Disrupts Functional and Morphological Development in Forebrain Neurons Leading to Cognitive and Social Deficits.
Oaks AW, Zamarbide M, Tambunan DE, Santini E, Di Costanzo S, Pond HL, Johnson MW, Lin J, Gonzalez DM, Boehler JF, Wu GK, Klann E, Walsh CA, Manzini MC
Cerebral cortex (New York, N.Y. : 1991)27(2)1670-1685(2017 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Freud-1 is crucial for 5-HT1A autoreceptor expression and links up-regulation of 5-HT1A autoreceptors to anxiety/depression-like behavior.
Title: Abrogated Freud-1/Cc2d1a Repression of 5-HT1A Autoreceptors Induces Fluoxetine-Resistant Anxiety/Depression-Like Behavior.
CC2D1A and CC2D1B role and function in the endocytic pathway and Notch signalling.
Title: The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling.
TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity
Title: TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity.
Cc2d1a is required for mouse survival and performs essential function in controlling functional maturation of synapses.
Title: Cc2d1a, a C2 domain containing protein linked to nonsyndromic mental retardation, controls functional maturation of central synapses.
Freud-1, is involved in the compensatory mechanisms that modulate the functional state of brain serotonin system, although it is not the only factor for 5-HT(1A) receptor transcriptional regulation.
Title: [On the role of selective silencer Freud-1 in the regulation of the brain 5-HT(1A) receptor gene expression].
The following Cc2d1a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Cc2d1a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu12077 | |
Clone ID Related Accession (Same CDS sequence) | NM_145970.2 , NM_145970.1 | |
Accession Version | NM_145970.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2832bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-30 | |
Organism | Mus musculus(house mouse) | |
Product | coiled-coil and C2 domain-containing protein 1A | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC159266.3. On Jun 16, 2018 this sequence version replaced NM_145970.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016188.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCACAAGA GGAATGGACC CCAGGCACCC CCGGGCCGAG GTGCTGTCAC TGCCCGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_666082.2 |
CDS | 212..3043 |
Translation |
Target ORF information:
Target ORF information:
|
NM_145970.2 |
1 | ATGCACAAGA GGAATGGACC CCAGGCACCC CCGGGCCGAG GTGCTGTCAC TGCCCGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu12077 | |
Clone ID Related Accession (Same CDS sequence) | NM_145970.2 , NM_145970.1 | |
Accession Version | NM_145970.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2832bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-12-17 | |
Organism | Mus musculus(house mouse) | |
Product | coiled-coil and C2 domain-containing protein 1A | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC016188.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC016188.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGCACAAGA GGAATGGACC CCAGGCACCC CCGGGCCGAG GTGCTGTCAC TGCCCGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_666082.2 |
CDS | 48..2879 |
Translation |
Target ORF information:
Target ORF information:
|
NM_145970.1 |
1 | ATGCACAAGA GGAATGGACC CCAGGCACCC CCGGGCCGAG GTGCTGTCAC TGCCCGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu41318 | |
Clone ID Related Accession (Same CDS sequence) | XM_006530810.2 , XM_006530810.3 | |
Accession Version | XM_006530810.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2829bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | coiled-coil and C2 domain-containing protein 1A isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006530810.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCACAAGA GGAATGGACC CCAGGCACCC CCGGGCCGAG GTGCTGTCAC TGCCCGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006530873.1 |
CDS | 226..3054 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006530810.2 |
1 | ATGCACAAGA GGAATGGACC CCAGGCACCC CCGGGCCGAG GTGCTGTCAC TGCCCGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu41318 | |
Clone ID Related Accession (Same CDS sequence) | XM_006530810.2 , XM_006530810.3 | |
Accession Version | XM_006530810.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2829bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | coiled-coil and C2 domain-containing protein 1A isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006530810.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCACAAGA GGAATGGACC CCAGGCACCC CCGGGCCGAG GTGCTGTCAC TGCCCGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006530873.1 |
CDS | 238..3066 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006530810.3 |
1 | ATGCACAAGA GGAATGGACC CCAGGCACCC CCGGGCCGAG GTGCTGTCAC TGCCCGCCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Abrogated Freud-1/Cc2d1a Repression of 5-HT1A Autoreceptors Induces Fluoxetine-Resistant Anxiety/Depression-Like Behavior. |
Cc2d1a Loss of Function Disrupts Functional and Morphological Development in Forebrain Neurons Leading to Cognitive and Social Deficits. |