Best2 cDNA ORF clone, Mus musculus(house mouse)

Gene
Clones
gRNAs

Gene Symbol	Best2
Entrez Gene ID	212989
Full Name	bestrophin 2
Synonyms	Vmd2l1
General protein information	Preferred Names bestrophin 2 Names bestrophin-2 vitelliform macular dystrophy 2-like protein 1
Gene Type	protein-coding
Organism	Mus musculus(house mouse)
Genome	Chromosome: 8 Map Location: 8\|8 C3

mRNA and Protein(s)

mRNA	Protein	Name
XM_011248341.3	XP_011246643.1	bestrophin-2 isoform X2
NM_001130194.1	NP_001123666.1	bestrophin-2
XM_011248341.2	XP_011246643.1	bestrophin-2 isoform X2
XM_006530819.1	XP_006530882.1	bestrophin-2 isoform X1
XM_006530820.1	XP_006530883.1	bestrophin-2 isoform X1

Pathways from BioSystems

Homologies

Bos taurus (cattle)	BEST2	XP_002688807.1
Mus musculus (house mouse)	Best2	NP_001123666.1
Rattus norvegicus (Norway rat)	Best2	NP_001102365.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011745	XP_320767.3
	BEST2	XP_001108800.1
Canis lupus familiaris (dog)	BEST2	XP_003639774.1
Drosophila melanogaster (fruit fly)	Best1	NP_652603.1
Pan troglodytes (chimpanzee)	BEST2	XP_512414.2
Danio rerio (zebrafish)	best2	XP_695597.1
Caenorhabditis elegans (roundworm)	best-23	NP_001122668.1
Xenopus tropicalis (tropical clawed frog)	best2	NP_988974.1
Homo sapiens (human)	BEST2	NP_060152.2

Gene Ontology
Bibliography

Related articles in PubMed

Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function.
Concepcion AR, Vaeth M, Wagner LE 2nd, Eckstein M, Hecht L, Yang J, Crottes D, Seidl M, Shin HP, Weidinger C, Cameron S, Turvey SE, Issekutz T, Meyts I, Lacruz RS, Cuk M, Yule DI, Feske S
The Journal of clinical investigation126(11)4303-4318(2016 Nov)

Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body.
Lee YS, Tresguerres M, Hess K, Marmorstein LY, Levin LR, Buck J, Marmorstein AD
The Journal of biological chemistry286(48)41353-8(2011 Dec)

Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon.
Yu K, Lujan R, Marmorstein A, Gabriel S, Hartzell HC
The Journal of clinical investigation120(5)1722-35(2010 May)

Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells.
Romanenko VG, Catal?n MA, Brown DA, Putzier I, Hartzell HC, Marmorstein AD, Gonzalez-Begne M, Rock JR, Harfe BD, Melvin JE
The Journal of biological chemistry285(17)12990-3001(2010 Apr)

Calcium-activated chloride currents in olfactory sensory neurons from mice lacking bestrophin-2.
Pifferi S, Dibattista M, Sagheddu C, Boccaccio A, Al Qteishat A, Ghirardi F, Tirindelli R, Menini A
The Journal of physiology587(Pt 17)4265-79(2009 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon
Title: Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon.

Results suggest that bestrophin 2 plays a critical role during differentiation and growth of axons and cilia.
Title: Bestrophin 2: an anion channel associated with neurogenesis in chemosensory systems.

Asp-rich domain has two defined binding sites and D301A and D304A mutations may impact the binding of the metal ions
Title: Regulation of bestrophins by Ca2+: a theoretical and experimental study.

suggest a role of bestrophin 1 and 2 for Ca(2+) dependent Cl(-) secretion in mouse airways
Title: Bestrophin 1 and 2 are components of the Ca(2+) activated Cl(-) conductance in mouse airways.

Determined HCO3(-)/Cl(-) transport via Best2 and the effect of disease causing mutations.
Title: Bestrophin Cl- channels are highly permeable to HCO3-.

The following Best2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Best2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OMu72817	XM_011248341.3 Latest version!	Mus musculus bestrophin 2 (Best2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OMu06096	NM_001130194.1 Latest version!	Mus musculus bestrophin 2 (Best2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
OMu06096	XM_006530820.1 Latest version!	Mus musculus bestrophin 2 (Best2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
OMu06096	XM_006530819.1 Latest version!	Mus musculus bestrophin 2 (Best2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$307.30 $439.00
View Old Accession Versions >>
OMu72817	XM_011248341.2	Mus musculus bestrophin 2 (Best2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Best2 ( XM_011248341.2 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011246643.1 Mus musculus bestrophin 2 (Best2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu72817
Clone ID Related Accession (Same CDS sequence)	XM_011248341.3 , XM_011248341.2
Accession Version	XM_011248341.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1440bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-21
Organism	Mus musculus(house mouse)
Product	bestrophin-2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011248341.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTTCCTG GGACTCTACA TGGCACTAAG CGCCGCCTAT CGCTACTGCA TTCCCTACCC 
CACAGCTTCT TACTGGCAGA AGAGCAGAAG CGCTACTTCG AGAAGCTTGT CATATACTGC 
GACCAGTACG CCAGCCTCAT CCCCGTCTCT TTCGTACTTG GCTTCTACGT GACTCTGGTG 
GTGCATCGCT GGTGGAACCA GTACCTATGC ATGCCTCTGC CGGACGCACT CATGTGCATA 
GTGGCTGGCA CCGTGCATGG GCGAGACGAT CGAGGCCGCC TCTACCGGCG CACGCTCATG 
CGCTACGCAG GGCTCTCCGC GGTGCTGATC CTTCGTTCTG TTAGCACAGC AGTCTTCAAA 
CGGTTCCCCA CTATAGACCA CGTGGTCGAG GCTGGATTTA TGACCCGAGA AGAGCGCAAG 
AAGTTCGAGA ACTTGAATTC GTCCTACAAC AAATACTGGG TGCCCTGCGT ATGGTTCTCG 
AGCCTGGCAG CGCAGGCGCG GCGAGAGGGG CGCATCCGCG ACAACAGTGC CCTAAAGTTG 
CTACTAGAGG AGCTGAATGT GTTTCGGAGC AAATGTGGGA TGCTGTTTCA CTACGACTGG 
ATTAGCATAC CCCTCGTCTA CACCCAGGTA GTCACTATCG CAGTGTACAG CTACTTCTTG 
GCTTGCCTCA TCGGCCGTCA GTTCCTAGAC CCTGCACAGG GCTACAAAGA CCACACCCTG 
GACCTATGCG TACCCATCTT CACCTTGCTG CAGTTCTTCT TCTACGCTGG CTGGCTTAAG 
GTAGCAGAGC AGCTTATTAA CCCTTTTGGG GAAGACGACG ACGACTTTGA GACCAACTTT 
CTTATTGACC GCAACTTCCA GGTGTCCATG CTAGCTGTAG ATGAGATGTA TGACGACTTG 
GCCATGCTGG AGAAAGATCT ATACTGGGAT GCAGCAGAAG CTCGCGCGCC CTACACCGCG 
GCCACCGCTT TCCTGCTTCA GCAGCCCTCC TTCCAGGGCT CCACCTTTGA TATAGCGCTG 
GCTAAAGAGG ACATGCAGTT CCAGCGGCTG GACGGCGTGG ATGGCCCGCT GGGAGAGGTT 
CACGGGGACT TTCTGCAGCG CCTCCTGCCG GCGGGGGCGG GTTCTGTGGG TCCGCTGGGG 
CGGCGCCTGT CGCTGTTAAG GCGTAAAAAC AGCTGCGTGT CAGAGGCCTC CACTGCTGCC 
AGCTGTGGCT GTGCAGGCGC GGCGGATGGC GGAGGCGTTG AGTGCGGTTG TGGAGACCCA 
TTGCTTGACC CCAGCCTGCG GGAGCCTGAG CTGGAGTCTC CCGCATGTCC TGAGCCGCCT 
GCCCCCATCC CGGGGCCAAC TCCTGAACCT TTTACCACCG TGTCGATTCC GGGTCCTCGG 
GCTCCTGCGC CACCCTGGCT GCCCAGCCCT ATTGGAGAGG AGGAAGAGAG TCCGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011246643.1
CDS	73..1512
Translation	MFPGTLHGTKRRLSLLHSLPHSFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAMLEKDLYWDAAEARAPYTAATAFLLQQPSFQGSTFDIALAKEDMQFQRLDGVDGPLGEVHGDFLQRLLPAGAGSVGPLGRRLSLLRRKNSCVSEASTAASCGCAGAADGGGVECGCGDPLLDPSLREPELESPACPEPPAPIPGPTPEPFTTVSIPGPRAPAPPWLPSPIGEEEESPA

Target ORF information:

RefSeq Version	XM_011248341.2
Organism	Mus musculus(house mouse)
Definition	Mus musculus bestrophin 2 (Best2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011248341.2

ORF Insert Sequence:

ATGTTTCCTG GGACTCTACA TGGCACTAAG CGCCGCCTAT CGCTACTGCA TTCCCTACCC 
CACAGCTTCT TACTGGCAGA AGAGCAGAAG CGCTACTTCG AGAAGCTTGT CATATACTGC 
GACCAGTACG CCAGCCTCAT CCCCGTCTCT TTCGTACTTG GCTTCTACGT GACTCTGGTG 
GTGCATCGCT GGTGGAACCA GTACCTATGC ATGCCTCTGC CGGACGCACT CATGTGCATA 
GTGGCTGGCA CCGTGCATGG GCGAGACGAT CGAGGCCGCC TCTACCGGCG CACGCTCATG 
CGCTACGCAG GGCTCTCCGC GGTGCTGATC CTTCGTTCTG TTAGCACAGC AGTCTTCAAA 
CGGTTCCCCA CTATAGACCA CGTGGTCGAG GCTGGATTTA TGACCCGAGA AGAGCGCAAG 
AAGTTCGAGA ACTTGAATTC GTCCTACAAC AAATACTGGG TGCCCTGCGT ATGGTTCTCG 
AGCCTGGCAG CGCAGGCGCG GCGAGAGGGG CGCATCCGCG ACAACAGTGC CCTAAAGTTG 
CTACTAGAGG AGCTGAATGT GTTTCGGAGC AAATGTGGGA TGCTGTTTCA CTACGACTGG 
ATTAGCATAC CCCTCGTCTA CACCCAGGTA GTCACTATCG CAGTGTACAG CTACTTCTTG 
GCTTGCCTCA TCGGCCGTCA GTTCCTAGAC CCTGCACAGG GCTACAAAGA CCACACCCTG 
GACCTATGCG TACCCATCTT CACCTTGCTG CAGTTCTTCT TCTACGCTGG CTGGCTTAAG 
GTAGCAGAGC AGCTTATTAA CCCTTTTGGG GAAGACGACG ACGACTTTGA GACCAACTTT 
CTTATTGACC GCAACTTCCA GGTGTCCATG CTAGCTGTAG ATGAGATGTA TGACGACTTG 
GCCATGCTGG AGAAAGATCT ATACTGGGAT GCAGCAGAAG CTCGCGCGCC CTACACCGCG 
GCCACCGCTT TCCTGCTTCA GCAGCCCTCC TTCCAGGGCT CCACCTTTGA TATAGCGCTG 
GCTAAAGAGG ACATGCAGTT CCAGCGGCTG GACGGCGTGG ATGGCCCGCT GGGAGAGGTT 
CACGGGGACT TTCTGCAGCG CCTCCTGCCG GCGGGGGCGG GTTCTGTGGG TCCGCTGGGG 
CGGCGCCTGT CGCTGTTAAG GCGTAAAAAC AGCTGCGTGT CAGAGGCCTC CACTGCTGCC 
AGCTGTGGCT GTGCAGGCGC GGCGGATGGC GGAGGCGTTG AGTGCGGTTG TGGAGACCCA 
TTGCTTGACC CCAGCCTGCG GGAGCCTGAG CTGGAGTCTC CCGCATGTCC TGAGCCGCCT 
GCCCCCATCC CGGGGCCAAC TCCTGAACCT TTTACCACCG TGTCGATTCC GGGTCCTCGG 
GCTCCTGCGC CACCCTGGCT GCCCAGCCCT ATTGGAGAGG AGGAAGAGAG TCCGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Best2 ( XM_011248341.3 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_011246643.1 Mus musculus bestrophin 2 (Best2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OMu72817
Clone ID Related Accession (Same CDS sequence)	XM_011248341.3 , XM_011248341.2
Accession Version	XM_011248341.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1440bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	bestrophin-2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011248341.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTTTCCTG GGACTCTACA TGGCACTAAG CGCCGCCTAT CGCTACTGCA TTCCCTACCC 
CACAGCTTCT TACTGGCAGA AGAGCAGAAG CGCTACTTCG AGAAGCTTGT CATATACTGC 
GACCAGTACG CCAGCCTCAT CCCCGTCTCT TTCGTACTTG GCTTCTACGT GACTCTGGTG 
GTGCATCGCT GGTGGAACCA GTACCTATGC ATGCCTCTGC CGGACGCACT CATGTGCATA 
GTGGCTGGCA CCGTGCATGG GCGAGACGAT CGAGGCCGCC TCTACCGGCG CACGCTCATG 
CGCTACGCAG GGCTCTCCGC GGTGCTGATC CTTCGTTCTG TTAGCACAGC AGTCTTCAAA 
CGGTTCCCCA CTATAGACCA CGTGGTCGAG GCTGGATTTA TGACCCGAGA AGAGCGCAAG 
AAGTTCGAGA ACTTGAATTC GTCCTACAAC AAATACTGGG TGCCCTGCGT ATGGTTCTCG 
AGCCTGGCAG CGCAGGCGCG GCGAGAGGGG CGCATCCGCG ACAACAGTGC CCTAAAGTTG 
CTACTAGAGG AGCTGAATGT GTTTCGGAGC AAATGTGGGA TGCTGTTTCA CTACGACTGG 
ATTAGCATAC CCCTCGTCTA CACCCAGGTA GTCACTATCG CAGTGTACAG CTACTTCTTG 
GCTTGCCTCA TCGGCCGTCA GTTCCTAGAC CCTGCACAGG GCTACAAAGA CCACACCCTG 
GACCTATGCG TACCCATCTT CACCTTGCTG CAGTTCTTCT TCTACGCTGG CTGGCTTAAG 
GTAGCAGAGC AGCTTATTAA CCCTTTTGGG GAAGACGACG ACGACTTTGA GACCAACTTT 
CTTATTGACC GCAACTTCCA GGTGTCCATG CTAGCTGTAG ATGAGATGTA TGACGACTTG 
GCCATGCTGG AGAAAGATCT ATACTGGGAT GCAGCAGAAG CTCGCGCGCC CTACACCGCG 
GCCACCGCTT TCCTGCTTCA GCAGCCCTCC TTCCAGGGCT CCACCTTTGA TATAGCGCTG 
GCTAAAGAGG ACATGCAGTT CCAGCGGCTG GACGGCGTGG ATGGCCCGCT GGGAGAGGTT 
CACGGGGACT TTCTGCAGCG CCTCCTGCCG GCGGGGGCGG GTTCTGTGGG TCCGCTGGGG 
CGGCGCCTGT CGCTGTTAAG GCGTAAAAAC AGCTGCGTGT CAGAGGCCTC CACTGCTGCC 
AGCTGTGGCT GTGCAGGCGC GGCGGATGGC GGAGGCGTTG AGTGCGGTTG TGGAGACCCA 
TTGCTTGACC CCAGCCTGCG GGAGCCTGAG CTGGAGTCTC CCGCATGTCC TGAGCCGCCT 
GCCCCCATCC CGGGGCCAAC TCCTGAACCT TTTACCACCG TGTCGATTCC GGGTCCTCGG 
GCTCCTGCGC CACCCTGGCT GCCCAGCCCT ATTGGAGAGG AGGAAGAGAG TCCGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011246643.1
CDS	67..1506
Translation	MFPGTLHGTKRRLSLLHSLPHSFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAMLEKDLYWDAAEARAPYTAATAFLLQQPSFQGSTFDIALAKEDMQFQRLDGVDGPLGEVHGDFLQRLLPAGAGSVGPLGRRLSLLRRKNSCVSEASTAASCGCAGAADGGGVECGCGDPLLDPSLREPELESPACPEPPAPIPGPTPEPFTTVSIPGPRAPAPPWLPSPIGEEEESPA

Target ORF information:

RefSeq Version	XM_011248341.3
Organism	Mus musculus(house mouse)
Definition	Mus musculus bestrophin 2 (Best2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011248341.3

ORF Insert Sequence:

ATGTTTCCTG GGACTCTACA TGGCACTAAG CGCCGCCTAT CGCTACTGCA TTCCCTACCC 
CACAGCTTCT TACTGGCAGA AGAGCAGAAG CGCTACTTCG AGAAGCTTGT CATATACTGC 
GACCAGTACG CCAGCCTCAT CCCCGTCTCT TTCGTACTTG GCTTCTACGT GACTCTGGTG 
GTGCATCGCT GGTGGAACCA GTACCTATGC ATGCCTCTGC CGGACGCACT CATGTGCATA 
GTGGCTGGCA CCGTGCATGG GCGAGACGAT CGAGGCCGCC TCTACCGGCG CACGCTCATG 
CGCTACGCAG GGCTCTCCGC GGTGCTGATC CTTCGTTCTG TTAGCACAGC AGTCTTCAAA 
CGGTTCCCCA CTATAGACCA CGTGGTCGAG GCTGGATTTA TGACCCGAGA AGAGCGCAAG 
AAGTTCGAGA ACTTGAATTC GTCCTACAAC AAATACTGGG TGCCCTGCGT ATGGTTCTCG 
AGCCTGGCAG CGCAGGCGCG GCGAGAGGGG CGCATCCGCG ACAACAGTGC CCTAAAGTTG 
CTACTAGAGG AGCTGAATGT GTTTCGGAGC AAATGTGGGA TGCTGTTTCA CTACGACTGG 
ATTAGCATAC CCCTCGTCTA CACCCAGGTA GTCACTATCG CAGTGTACAG CTACTTCTTG 
GCTTGCCTCA TCGGCCGTCA GTTCCTAGAC CCTGCACAGG GCTACAAAGA CCACACCCTG 
GACCTATGCG TACCCATCTT CACCTTGCTG CAGTTCTTCT TCTACGCTGG CTGGCTTAAG 
GTAGCAGAGC AGCTTATTAA CCCTTTTGGG GAAGACGACG ACGACTTTGA GACCAACTTT 
CTTATTGACC GCAACTTCCA GGTGTCCATG CTAGCTGTAG ATGAGATGTA TGACGACTTG 
GCCATGCTGG AGAAAGATCT ATACTGGGAT GCAGCAGAAG CTCGCGCGCC CTACACCGCG 
GCCACCGCTT TCCTGCTTCA GCAGCCCTCC TTCCAGGGCT CCACCTTTGA TATAGCGCTG 
GCTAAAGAGG ACATGCAGTT CCAGCGGCTG GACGGCGTGG ATGGCCCGCT GGGAGAGGTT 
CACGGGGACT TTCTGCAGCG CCTCCTGCCG GCGGGGGCGG GTTCTGTGGG TCCGCTGGGG 
CGGCGCCTGT CGCTGTTAAG GCGTAAAAAC AGCTGCGTGT CAGAGGCCTC CACTGCTGCC 
AGCTGTGGCT GTGCAGGCGC GGCGGATGGC GGAGGCGTTG AGTGCGGTTG TGGAGACCCA 
TTGCTTGACC CCAGCCTGCG GGAGCCTGAG CTGGAGTCTC CCGCATGTCC TGAGCCGCCT 
GCCCCCATCC CGGGGCCAAC TCCTGAACCT TTTACCACCG TGTCGATTCC GGGTCCTCGG 
GCTCCTGCGC CACCCTGGCT GCCCAGCCCT ATTGGAGAGG AGGAAGAGAG TCCGGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Best2 ( NM_001130194.1 ) cDNA ORF clone, Mus musculus(house mouse) -> NP_001123666.1 Mus musculus bestrophin 2 (Best2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OMu06096
Clone ID Related Accession (Same CDS sequence)	NM_001130194.1 , XM_006530819.1 , XM_006530820.1
Accession Version	NM_001130194.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1527bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Mus musculus(house mouse)
Product	bestrophin-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC163703.4, BY096795.1 and AY450428.1. Transcript Variant: This variant (1) encodes the functional protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC036157.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849389 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCGTCA CCTACACAGC CAGAGTGGCG AATGCCCGCT TCGGTGGCTT CTCGCAGCTG 
CTGCTGCTGT GGCGCGGAAG CATCTACAAG CTCCTGTGGC GAGAGCTGTT ATGTTTCCTG 
GGACTCTACA TGGCACTAAG CGCCGCCTAT CGCTTCTTAC TGGCAGAAGA GCAGAAGCGC 
TACTTCGAGA AGCTTGTCAT ATACTGCGAC CAGTACGCCA GCCTCATCCC CGTCTCTTTC 
GTACTTGGCT TCTACGTGAC TCTGGTGGTG CATCGCTGGT GGAACCAGTA CCTATGCATG 
CCTCTGCCGG ACGCACTCAT GTGCATAGTG GCTGGCACCG TGCATGGGCG AGACGATCGA 
GGCCGCCTCT ACCGGCGCAC GCTCATGCGC TACGCAGGGC TCTCCGCGGT GCTGATCCTT 
CGTTCTGTTA GCACAGCAGT CTTCAAACGG TTCCCCACTA TAGACCACGT GGTCGAGGCT 
GGATTTATGA CCCGAGAAGA GCGCAAGAAG TTCGAGAACT TGAATTCGTC CTACAACAAA 
TACTGGGTGC CCTGCGTATG GTTCTCGAGC CTGGCAGCGC AGGCGCGGCG AGAGGGGCGC 
ATCCGCGACA ACAGTGCCCT AAAGTTGCTA CTAGAGGAGC TGAATGTGTT TCGGAGCAAA 
TGTGGGATGC TGTTTCACTA CGACTGGATT AGCATACCCC TCGTCTACAC CCAGGTAGTC 
ACTATCGCAG TGTACAGCTA CTTCTTGGCT TGCCTCATCG GCCGTCAGTT CCTAGACCCT 
GCACAGGGCT ACAAAGACCA CACCCTGGAC CTATGCGTAC CCATCTTCAC CTTGCTGCAG 
TTCTTCTTCT ACGCTGGCTG GCTTAAGGTA GCAGAGCAGC TTATTAACCC TTTTGGGGAA 
GACGACGACG ACTTTGAGAC CAACTTTCTT ATTGACCGCA ACTTCCAGGT GTCCATGCTA 
GCTGTAGATG AGATGTATGA CGACTTGGCC ATGCTGGAGA AAGATCTATA CTGGGATGCA 
GCAGAAGCTC GCGCGCCCTA CACCGCGGCC ACCGCTTTCC TGCTTCAGCA GCCCTCCTTC 
CAGGGCTCCA CCTTTGATAT AGCGCTGGCT AAAGAGGACA TGCAGTTCCA GCGGCTGGAC 
GGCGTGGATG GCCCGCTGGG AGAGGTTCAC GGGGACTTTC TGCAGCGCCT CCTGCCGGCG 
GGGGCGGGTT CTGTGGGTCC GCTGGGGCGG CGCCTGTCGC TGTTAAGGCG TAAAAACAGC 
TGCGTGTCAG AGGCCTCCAC TGCTGCCAGC TGTGGCTGTG CAGGCGCGGC GGATGGCGGA 
GGCGTTGAGT GCGGTTGTGG AGACCCATTG CTTGACCCCA GCCTGCGGGA GCCTGAGCTG 
GAGTCTCCCG CATGTCCTGA GCCGCCTGCC CCCATCCCGG GGCCAACTCC TGAACCTTTT 
ACCACCGTGT CGATTCCGGG TCCTCGGGCT CCTGCGCCAC CCTGGCTGCC CAGCCCTATT 
GGAGAGGAGG AAGAGAGTCC GGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001123666.1
CDS	86..1612
Translation	MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAMLEKDLYWDAAEARAPYTAATAFLLQQPSFQGSTFDIALAKEDMQFQRLDGVDGPLGEVHGDFLQRLLPAGAGSVGPLGRRLSLLRRKNSCVSEASTAASCGCAGAADGGGVECGCGDPLLDPSLREPELESPACPEPPAPIPGPTPEPFTTVSIPGPRAPAPPWLPSPIGEEEESPA

Target ORF information:

RefSeq Version	NM_001130194.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus bestrophin 2 (Best2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001130194.1

ORF Insert Sequence:

ATGACCGTCA CCTACACAGC CAGAGTGGCG AATGCCCGCT TCGGTGGCTT CTCGCAGCTG 
CTGCTGCTGT GGCGCGGAAG CATCTACAAG CTCCTGTGGC GAGAGCTGTT ATGTTTCCTG 
GGACTCTACA TGGCACTAAG CGCCGCCTAT CGCTTCTTAC TGGCAGAAGA GCAGAAGCGC 
TACTTCGAGA AGCTTGTCAT ATACTGCGAC CAGTACGCCA GCCTCATCCC CGTCTCTTTC 
GTACTTGGCT TCTACGTGAC TCTGGTGGTG CATCGCTGGT GGAACCAGTA CCTATGCATG 
CCTCTGCCGG ACGCACTCAT GTGCATAGTG GCTGGCACCG TGCATGGGCG AGACGATCGA 
GGCCGCCTCT ACCGGCGCAC GCTCATGCGC TACGCAGGGC TCTCCGCGGT GCTGATCCTT 
CGTTCTGTTA GCACAGCAGT CTTCAAACGG TTCCCCACTA TAGACCACGT GGTCGAGGCT 
GGATTTATGA CCCGAGAAGA GCGCAAGAAG TTCGAGAACT TGAATTCGTC CTACAACAAA 
TACTGGGTGC CCTGCGTATG GTTCTCGAGC CTGGCAGCGC AGGCGCGGCG AGAGGGGCGC 
ATCCGCGACA ACAGTGCCCT AAAGTTGCTA CTAGAGGAGC TGAATGTGTT TCGGAGCAAA 
TGTGGGATGC TGTTTCACTA CGACTGGATT AGCATACCCC TCGTCTACAC CCAGGTAGTC 
ACTATCGCAG TGTACAGCTA CTTCTTGGCT TGCCTCATCG GCCGTCAGTT CCTAGACCCT 
GCACAGGGCT ACAAAGACCA CACCCTGGAC CTATGCGTAC CCATCTTCAC CTTGCTGCAG 
TTCTTCTTCT ACGCTGGCTG GCTTAAGGTA GCAGAGCAGC TTATTAACCC TTTTGGGGAA 
GACGACGACG ACTTTGAGAC CAACTTTCTT ATTGACCGCA ACTTCCAGGT GTCCATGCTA 
GCTGTAGATG AGATGTATGA CGACTTGGCC ATGCTGGAGA AAGATCTATA CTGGGATGCA 
GCAGAAGCTC GCGCGCCCTA CACCGCGGCC ACCGCTTTCC TGCTTCAGCA GCCCTCCTTC 
CAGGGCTCCA CCTTTGATAT AGCGCTGGCT AAAGAGGACA TGCAGTTCCA GCGGCTGGAC 
GGCGTGGATG GCCCGCTGGG AGAGGTTCAC GGGGACTTTC TGCAGCGCCT CCTGCCGGCG 
GGGGCGGGTT CTGTGGGTCC GCTGGGGCGG CGCCTGTCGC TGTTAAGGCG TAAAAACAGC 
TGCGTGTCAG AGGCCTCCAC TGCTGCCAGC TGTGGCTGTG CAGGCGCGGC GGATGGCGGA 
GGCGTTGAGT GCGGTTGTGG AGACCCATTG CTTGACCCCA GCCTGCGGGA GCCTGAGCTG 
GAGTCTCCCG CATGTCCTGA GCCGCCTGCC CCCATCCCGG GGCCAACTCC TGAACCTTTT 
ACCACCGTGT CGATTCCGGG TCCTCGGGCT CCTGCGCCAC CCTGGCTGCC CAGCCCTATT 
GGAGAGGAGG AAGAGAGTCC GGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Best2 ( XM_006530819.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006530882.1 Mus musculus bestrophin 2 (Best2), transcript variant X1, mRNA.

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CloneID	OMu06096
Clone ID Related Accession (Same CDS sequence)	NM_001130194.1 , XM_006530819.1 , XM_006530820.1
Accession Version	XM_006530819.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1527bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-02-08
Organism	Mus musculus(House mouse)
Product	bestrophin-2 isoform X1
Comment

ATGACCGTCA CCTACACAGC CAGAGTGGCG AATGCCCGCT TCGGTGGCTT CTCGCAGCTG 
CTGCTGCTGT GGCGCGGAAG CATCTACAAG CTCCTGTGGC GAGAGCTGTT ATGTTTCCTG 
GGACTCTACA TGGCACTAAG CGCCGCCTAT CGCTTCTTAC TGGCAGAAGA GCAGAAGCGC 
TACTTCGAGA AGCTTGTCAT ATACTGCGAC CAGTACGCCA GCCTCATCCC CGTCTCTTTC 
GTACTTGGCT TCTACGTGAC TCTGGTGGTG CATCGCTGGT GGAACCAGTA CCTATGCATG 
CCTCTGCCGG ACGCACTCAT GTGCATAGTG GCTGGCACCG TGCATGGGCG AGACGATCGA 
GGCCGCCTCT ACCGGCGCAC GCTCATGCGC TACGCAGGGC TCTCCGCGGT GCTGATCCTT 
CGTTCTGTTA GCACAGCAGT CTTCAAACGG TTCCCCACTA TAGACCACGT GGTCGAGGCT 
GGATTTATGA CCCGAGAAGA GCGCAAGAAG TTCGAGAACT TGAATTCGTC CTACAACAAA 
TACTGGGTGC CCTGCGTATG GTTCTCGAGC CTGGCAGCGC AGGCGCGGCG AGAGGGGCGC 
ATCCGCGACA ACAGTGCCCT AAAGTTGCTA CTAGAGGAGC TGAATGTGTT TCGGAGCAAA 
TGTGGGATGC TGTTTCACTA CGACTGGATT AGCATACCCC TCGTCTACAC CCAGGTAGTC 
ACTATCGCAG TGTACAGCTA CTTCTTGGCT TGCCTCATCG GCCGTCAGTT CCTAGACCCT 
GCACAGGGCT ACAAAGACCA CACCCTGGAC CTATGCGTAC CCATCTTCAC CTTGCTGCAG 
TTCTTCTTCT ACGCTGGCTG GCTTAAGGTA GCAGAGCAGC TTATTAACCC TTTTGGGGAA 
GACGACGACG ACTTTGAGAC CAACTTTCTT ATTGACCGCA ACTTCCAGGT GTCCATGCTA 
GCTGTAGATG AGATGTATGA CGACTTGGCC ATGCTGGAGA AAGATCTATA CTGGGATGCA 
GCAGAAGCTC GCGCGCCCTA CACCGCGGCC ACCGCTTTCC TGCTTCAGCA GCCCTCCTTC 
CAGGGCTCCA CCTTTGATAT AGCGCTGGCT AAAGAGGACA TGCAGTTCCA GCGGCTGGAC 
GGCGTGGATG GCCCGCTGGG AGAGGTTCAC GGGGACTTTC TGCAGCGCCT CCTGCCGGCG 
GGGGCGGGTT CTGTGGGTCC GCTGGGGCGG CGCCTGTCGC TGTTAAGGCG TAAAAACAGC 
TGCGTGTCAG AGGCCTCCAC TGCTGCCAGC TGTGGCTGTG CAGGCGCGGC GGATGGCGGA 
GGCGTTGAGT GCGGTTGTGG AGACCCATTG CTTGACCCCA GCCTGCGGGA GCCTGAGCTG 
GAGTCTCCCG CATGTCCTGA GCCGCCTGCC CCCATCCCGG GGCCAACTCC TGAACCTTTT 
ACCACCGTGT CGATTCCGGG TCCTCGGGCT CCTGCGCCAC CCTGGCTGCC CAGCCCTATT 
GGAGAGGAGG AAGAGAGTCC GGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

XP_006530882.1

Translation

MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAMLEKDLYWDAAEARAPYTAATAFLLQQPSFQGSTFDIALAKEDMQFQRLDGVDGPLGEVHGDFLQRLLPAGAGSVGPLGRRLSLLRRKNSCVSEASTAASCGCAGAADGGGVECGCGDPLLDPSLREPELESPACPEPPAPIPGPTPEPFTTVSIPGPRAPAPPWLPSPIGEEEESPA

Target ORF information:

RefSeq Version	XM_006530819.1
Organism	Mus musculus(House mouse)
Definition	Mus musculus bestrophin 2 (Best2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006530819.1

ORF Insert Sequence:

ATGACCGTCA CCTACACAGC CAGAGTGGCG AATGCCCGCT TCGGTGGCTT CTCGCAGCTG 
CTGCTGCTGT GGCGCGGAAG CATCTACAAG CTCCTGTGGC GAGAGCTGTT ATGTTTCCTG 
GGACTCTACA TGGCACTAAG CGCCGCCTAT CGCTTCTTAC TGGCAGAAGA GCAGAAGCGC 
TACTTCGAGA AGCTTGTCAT ATACTGCGAC CAGTACGCCA GCCTCATCCC CGTCTCTTTC 
GTACTTGGCT TCTACGTGAC TCTGGTGGTG CATCGCTGGT GGAACCAGTA CCTATGCATG 
CCTCTGCCGG ACGCACTCAT GTGCATAGTG GCTGGCACCG TGCATGGGCG AGACGATCGA 
GGCCGCCTCT ACCGGCGCAC GCTCATGCGC TACGCAGGGC TCTCCGCGGT GCTGATCCTT 
CGTTCTGTTA GCACAGCAGT CTTCAAACGG TTCCCCACTA TAGACCACGT GGTCGAGGCT 
GGATTTATGA CCCGAGAAGA GCGCAAGAAG TTCGAGAACT TGAATTCGTC CTACAACAAA 
TACTGGGTGC CCTGCGTATG GTTCTCGAGC CTGGCAGCGC AGGCGCGGCG AGAGGGGCGC 
ATCCGCGACA ACAGTGCCCT AAAGTTGCTA CTAGAGGAGC TGAATGTGTT TCGGAGCAAA 
TGTGGGATGC TGTTTCACTA CGACTGGATT AGCATACCCC TCGTCTACAC CCAGGTAGTC 
ACTATCGCAG TGTACAGCTA CTTCTTGGCT TGCCTCATCG GCCGTCAGTT CCTAGACCCT 
GCACAGGGCT ACAAAGACCA CACCCTGGAC CTATGCGTAC CCATCTTCAC CTTGCTGCAG 
TTCTTCTTCT ACGCTGGCTG GCTTAAGGTA GCAGAGCAGC TTATTAACCC TTTTGGGGAA 
GACGACGACG ACTTTGAGAC CAACTTTCTT ATTGACCGCA ACTTCCAGGT GTCCATGCTA 
GCTGTAGATG AGATGTATGA CGACTTGGCC ATGCTGGAGA AAGATCTATA CTGGGATGCA 
GCAGAAGCTC GCGCGCCCTA CACCGCGGCC ACCGCTTTCC TGCTTCAGCA GCCCTCCTTC 
CAGGGCTCCA CCTTTGATAT AGCGCTGGCT AAAGAGGACA TGCAGTTCCA GCGGCTGGAC 
GGCGTGGATG GCCCGCTGGG AGAGGTTCAC GGGGACTTTC TGCAGCGCCT CCTGCCGGCG 
GGGGCGGGTT CTGTGGGTCC GCTGGGGCGG CGCCTGTCGC TGTTAAGGCG TAAAAACAGC 
TGCGTGTCAG AGGCCTCCAC TGCTGCCAGC TGTGGCTGTG CAGGCGCGGC GGATGGCGGA 
GGCGTTGAGT GCGGTTGTGG AGACCCATTG CTTGACCCCA GCCTGCGGGA GCCTGAGCTG 
GAGTCTCCCG CATGTCCTGA GCCGCCTGCC CCCATCCCGG GGCCAACTCC TGAACCTTTT 
ACCACCGTGT CGATTCCGGG TCCTCGGGCT CCTGCGCCAC CCTGGCTGCC CAGCCCTATT 
GGAGAGGAGG AAGAGAGTCC GGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Best2 ( XM_006530820.1 ) cDNA ORF clone, Mus musculus(house mouse) -> XP_006530883.1 Mus musculus bestrophin 2 (Best2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OMu06096
Clone ID Related Accession (Same CDS sequence)	NM_001130194.1 , XM_006530819.1 , XM_006530820.1
Accession Version	XM_006530820.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1527bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Mus musculus(house mouse)
Product	bestrophin-2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCGTCA CCTACACAGC CAGAGTGGCG AATGCCCGCT TCGGTGGCTT CTCGCAGCTG 
CTGCTGCTGT GGCGCGGAAG CATCTACAAG CTCCTGTGGC GAGAGCTGTT ATGTTTCCTG 
GGACTCTACA TGGCACTAAG CGCCGCCTAT CGCTTCTTAC TGGCAGAAGA GCAGAAGCGC 
TACTTCGAGA AGCTTGTCAT ATACTGCGAC CAGTACGCCA GCCTCATCCC CGTCTCTTTC 
GTACTTGGCT TCTACGTGAC TCTGGTGGTG CATCGCTGGT GGAACCAGTA CCTATGCATG 
CCTCTGCCGG ACGCACTCAT GTGCATAGTG GCTGGCACCG TGCATGGGCG AGACGATCGA 
GGCCGCCTCT ACCGGCGCAC GCTCATGCGC TACGCAGGGC TCTCCGCGGT GCTGATCCTT 
CGTTCTGTTA GCACAGCAGT CTTCAAACGG TTCCCCACTA TAGACCACGT GGTCGAGGCT 
GGATTTATGA CCCGAGAAGA GCGCAAGAAG TTCGAGAACT TGAATTCGTC CTACAACAAA 
TACTGGGTGC CCTGCGTATG GTTCTCGAGC CTGGCAGCGC AGGCGCGGCG AGAGGGGCGC 
ATCCGCGACA ACAGTGCCCT AAAGTTGCTA CTAGAGGAGC TGAATGTGTT TCGGAGCAAA 
TGTGGGATGC TGTTTCACTA CGACTGGATT AGCATACCCC TCGTCTACAC CCAGGTAGTC 
ACTATCGCAG TGTACAGCTA CTTCTTGGCT TGCCTCATCG GCCGTCAGTT CCTAGACCCT 
GCACAGGGCT ACAAAGACCA CACCCTGGAC CTATGCGTAC CCATCTTCAC CTTGCTGCAG 
TTCTTCTTCT ACGCTGGCTG GCTTAAGGTA GCAGAGCAGC TTATTAACCC TTTTGGGGAA 
GACGACGACG ACTTTGAGAC CAACTTTCTT ATTGACCGCA ACTTCCAGGT GTCCATGCTA 
GCTGTAGATG AGATGTATGA CGACTTGGCC ATGCTGGAGA AAGATCTATA CTGGGATGCA 
GCAGAAGCTC GCGCGCCCTA CACCGCGGCC ACCGCTTTCC TGCTTCAGCA GCCCTCCTTC 
CAGGGCTCCA CCTTTGATAT AGCGCTGGCT AAAGAGGACA TGCAGTTCCA GCGGCTGGAC 
GGCGTGGATG GCCCGCTGGG AGAGGTTCAC GGGGACTTTC TGCAGCGCCT CCTGCCGGCG 
GGGGCGGGTT CTGTGGGTCC GCTGGGGCGG CGCCTGTCGC TGTTAAGGCG TAAAAACAGC 
TGCGTGTCAG AGGCCTCCAC TGCTGCCAGC TGTGGCTGTG CAGGCGCGGC GGATGGCGGA 
GGCGTTGAGT GCGGTTGTGG AGACCCATTG CTTGACCCCA GCCTGCGGGA GCCTGAGCTG 
GAGTCTCCCG CATGTCCTGA GCCGCCTGCC CCCATCCCGG GGCCAACTCC TGAACCTTTT 
ACCACCGTGT CGATTCCGGG TCCTCGGGCT CCTGCGCCAC CCTGGCTGCC CAGCCCTATT 
GGAGAGGAGG AAGAGAGTCC GGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006530883.1
CDS	220..1746
Translation	MTVTYTARVANARFGGFSQLLLLWRGSIYKLLWRELLCFLGLYMALSAAYRFLLAEEQKRYFEKLVIYCDQYASLIPVSFVLGFYVTLVVHRWWNQYLCMPLPDALMCIVAGTVHGRDDRGRLYRRTLMRYAGLSAVLILRSVSTAVFKRFPTIDHVVEAGFMTREERKKFENLNSSYNKYWVPCVWFSSLAAQARREGRIRDNSALKLLLEELNVFRSKCGMLFHYDWISIPLVYTQVVTIAVYSYFLACLIGRQFLDPAQGYKDHTLDLCVPIFTLLQFFFYAGWLKVAEQLINPFGEDDDDFETNFLIDRNFQVSMLAVDEMYDDLAMLEKDLYWDAAEARAPYTAATAFLLQQPSFQGSTFDIALAKEDMQFQRLDGVDGPLGEVHGDFLQRLLPAGAGSVGPLGRRLSLLRRKNSCVSEASTAASCGCAGAADGGGVECGCGDPLLDPSLREPELESPACPEPPAPIPGPTPEPFTTVSIPGPRAPAPPWLPSPIGEEEESPA

Target ORF information:

RefSeq Version	XM_006530820.1
Organism	Mus musculus(house mouse)
Definition	Mus musculus bestrophin 2 (Best2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006530820.1

ORF Insert Sequence:

ATGACCGTCA CCTACACAGC CAGAGTGGCG AATGCCCGCT TCGGTGGCTT CTCGCAGCTG 
CTGCTGCTGT GGCGCGGAAG CATCTACAAG CTCCTGTGGC GAGAGCTGTT ATGTTTCCTG 
GGACTCTACA TGGCACTAAG CGCCGCCTAT CGCTTCTTAC TGGCAGAAGA GCAGAAGCGC 
TACTTCGAGA AGCTTGTCAT ATACTGCGAC CAGTACGCCA GCCTCATCCC CGTCTCTTTC 
GTACTTGGCT TCTACGTGAC TCTGGTGGTG CATCGCTGGT GGAACCAGTA CCTATGCATG 
CCTCTGCCGG ACGCACTCAT GTGCATAGTG GCTGGCACCG TGCATGGGCG AGACGATCGA 
GGCCGCCTCT ACCGGCGCAC GCTCATGCGC TACGCAGGGC TCTCCGCGGT GCTGATCCTT 
CGTTCTGTTA GCACAGCAGT CTTCAAACGG TTCCCCACTA TAGACCACGT GGTCGAGGCT 
GGATTTATGA CCCGAGAAGA GCGCAAGAAG TTCGAGAACT TGAATTCGTC CTACAACAAA 
TACTGGGTGC CCTGCGTATG GTTCTCGAGC CTGGCAGCGC AGGCGCGGCG AGAGGGGCGC 
ATCCGCGACA ACAGTGCCCT AAAGTTGCTA CTAGAGGAGC TGAATGTGTT TCGGAGCAAA 
TGTGGGATGC TGTTTCACTA CGACTGGATT AGCATACCCC TCGTCTACAC CCAGGTAGTC 
ACTATCGCAG TGTACAGCTA CTTCTTGGCT TGCCTCATCG GCCGTCAGTT CCTAGACCCT 
GCACAGGGCT ACAAAGACCA CACCCTGGAC CTATGCGTAC CCATCTTCAC CTTGCTGCAG 
TTCTTCTTCT ACGCTGGCTG GCTTAAGGTA GCAGAGCAGC TTATTAACCC TTTTGGGGAA 
GACGACGACG ACTTTGAGAC CAACTTTCTT ATTGACCGCA ACTTCCAGGT GTCCATGCTA 
GCTGTAGATG AGATGTATGA CGACTTGGCC ATGCTGGAGA AAGATCTATA CTGGGATGCA 
GCAGAAGCTC GCGCGCCCTA CACCGCGGCC ACCGCTTTCC TGCTTCAGCA GCCCTCCTTC 
CAGGGCTCCA CCTTTGATAT AGCGCTGGCT AAAGAGGACA TGCAGTTCCA GCGGCTGGAC 
GGCGTGGATG GCCCGCTGGG AGAGGTTCAC GGGGACTTTC TGCAGCGCCT CCTGCCGGCG 
GGGGCGGGTT CTGTGGGTCC GCTGGGGCGG CGCCTGTCGC TGTTAAGGCG TAAAAACAGC 
TGCGTGTCAG AGGCCTCCAC TGCTGCCAGC TGTGGCTGTG CAGGCGCGGC GGATGGCGGA 
GGCGTTGAGT GCGGTTGTGG AGACCCATTG CTTGACCCCA GCCTGCGGGA GCCTGAGCTG 
GAGTCTCCCG CATGTCCTGA GCCGCCTGCC CCCATCCCGG GGCCAACTCC TGAACCTTTT 
ACCACCGTGT CGATTCCGGG TCCTCGGGCT CCTGCGCCAC CCTGGCTGCC CAGCCCTATT 
GGAGAGGAGG AAGAGAGTCC GGCCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Store-operated Ca2+ entry regulates Ca2+-activated chloride channels and eccrine sweat gland function.
The Journal of clinical investigation126(11)4303-4318(2016 Nov)
Concepcion AR,Vaeth M,Wagner LE 2nd,Eckstein M,Hecht L,Yang J,Crottes D,Seidl M,Shin HP,Weidinger C,Cameron S,Turvey SE,Issekutz T,Meyts I,Lacruz RS,Cuk M,Yule DI,Feske S

Regulation of anterior chamber drainage by bicarbonate-sensitive soluble adenylyl cyclase in the ciliary body.
The Journal of biological chemistry286(48)41353-8(2011 Dec)
Lee YS,Tresguerres M,Hess K,Marmorstein LY,Levin LR,Buck J,Marmorstein AD

Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon.
The Journal of clinical investigation120(5)1722-35(2010 May)
Yu K,Lujan R,Marmorstein A,Gabriel S,Hartzell HC

Tmem16A encodes the Ca2+-activated Cl- channel in mouse submandibular salivary gland acinar cells.
The Journal of biological chemistry285(17)12990-3001(2010 Apr)
Romanenko VG,Catal?n MA,Brown DA,Putzier I,Hartzell HC,Marmorstein AD,Gonzalez-Begne M,Rock JR,Harfe BD,Melvin JE

Calcium-activated chloride currents in olfactory sensory neurons from mice lacking bestrophin-2.
The Journal of physiology587(Pt 17)4265-79(2009 Sep)
Pifferi S,Dibattista M,Sagheddu C,Boccaccio A,Al Qteishat A,Ghirardi F,Tirindelli R,Menini A

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Best2 cDNA ORF clone, Mus musculus(house mouse)

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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