Gene Symbol | Wdr19 |
Entrez Gene ID | 213081 |
Full Name | WD repeat domain 19 |
Synonyms | C330027H04Rik,D330023L08Rik,DYF2,Ift144,PWDMP,mKIAA1638 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Wdr19 cDNA ORF clone
gRNAs
Gene Symbol | Wdr19 |
Entrez Gene ID | 213081 |
Full Name | WD repeat domain 19 |
Synonyms | C330027H04Rik,D330023L08Rik,DYF2,Ift144,PWDMP,mKIAA1638 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001359880.1 | NP_001346809.1 | WD repeat-containing protein 19 isoform a |
XM_011240713.1 | XP_011239015.1 | WD repeat-containing protein 19 isoform X1 |
NM_001359879.1 | NP_001346808.1 | WD repeat-containing protein 19 isoform a |
NM_153391.2 | NP_700440.2 | WD repeat-containing protein 19 isoform a |
Mus musculus (house mouse) | Wdr19 | NP_700440.2 |
Gallus gallus (chicken) | WDR19 | XP_428380.3 |
Drosophila melanogaster (fruit fly) | Oseg6 | NP_611426.1 |
Caenorhabditis elegans (roundworm) | dyf-2 | NP_001076655.1 |
Homo sapiens (human) | WDR19 | NP_079408.3 |
WDR19 | XP_001090341.1 | |
Canis lupus familiaris (dog) | WDR19 | XP_005618677.1 |
Danio rerio (zebrafish) | wdr19 | XP_684320.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010418 | XP_559033.3 |
Pan troglodytes (chimpanzee) | WDR19 | XP_517152.2 |
Bos taurus (cattle) | WDR19 | NP_001192956.1 |
Rattus norvegicus (Norway rat) | Wdr19 | NP_001178608.2 |
Primary cilia function regulates the length of the embryonic trunk axis and urogenital field in mice.
Wainwright EN, Svingen T, Ng ET, Wicking C, Koopman P
Developmental biology395(2)342-54(2014 Nov)
The BBSome controls IFT assembly and turnaround in cilia.
Wei Q, Zhang Y, Li Y, Zhang Q, Ling K, Hu J
Nature cell biology14(9)950-7(2012 Sep)
The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking.
Liem KF Jr, Ashe A, He M, Satir P, Moran J, Beier D, Wicking C, Anderson KV
The Journal of cell biology197(6)789-800(2012 Jun)
Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies.
Ashe A, Butterfield NC, Town L, Courtney AD, Cooper AN, Ferguson C, Barry R, Olsson F, Liem KF Jr, Parton RG, Wainwright BJ, Anderson KV, Whitelaw E, Wicking C
Human molecular genetics21(8)1808-23(2012 Apr)
TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia.
Mukhopadhyay S, Wen X, Chih B, Nelson CD, Lane WS, Scales SJ, Jackson PK
Genes & development24(19)2180-93(2010 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Mutations in Ift144, encoding a component of the trafficking machinery of primary cilia assembly, result in a range of embryo patterning defects, affecting the limbs, skeleton and neural system. Here, we show that embryos
Title: Primary cilia function regulates the length of the embryonic trunk axis and urogenital field in mice.
A weak allele of the IFT-A gene, Ift144, caused subtle defects in cilia structure and ectopic activation of the Shh pathway.
Title: The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking.
study describes a mouse with an N-ethyl-N-nitrosourea -induced hypomorphic mutation in the gene encoding the IFT-A protein WDR19/IFT144; phenotypically, this mutant, twinkle-toes (Ift144twt), displays a number of features reminiscent of skeletal ciliopathies; Ift144 mutant embryos display a generalized ligand-independent expansion of hedgehog signalling
Title: Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies.
Expressed in normal and neoplastic prostate epithelium and is regulated by androgenic hormones.
Title: Isolation and characterization of human and mouse WDR19,a novel WD-repeat protein exhibiting androgen-regulated expression in prostate epithelium.
The following Wdr19 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Wdr19 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu22328 | |
Clone ID Related Accession (Same CDS sequence) | XM_011240713.1 , NM_001359879.1 , NM_153391.2 | |
Accession Version | NM_001359879.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4026bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-21 | |
Organism | Mus musculus(house mouse) | |
Product | WD repeat-containing protein 19 isoform a | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK147970.1 and AC138654.4. On Jan 18, 2018 this sequence version replaced XM_011240713.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a). ##Evidence-Data-START## Transcript exon combination :: AK147970.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAAGCGTG TTTTCTCCCT GCTAGAAAAG TCTTGGCTTG GTGCTCCGAT ACAATTTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001346808.1 |
CDS | 60..4085 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGAAGCGTG TTTTCTCCCT GCTAGAAAAG TCTTGGCTTG GTGCTCCGAT ACAATTTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu22328 | |
Clone ID Related Accession (Same CDS sequence) | XM_011240713.1 , NM_001359879.1 , NM_153391.2 | |
Accession Version | NM_153391.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4026bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-21 | |
Organism | Mus musculus(house mouse) | |
Product | WD repeat-containing protein 19 isoform a | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC132222.3 and AC138654.4. On Jul 31, 2007 this sequence version replaced NM_153391.1. Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variant 1 and 2 both encode the same isoform (a). Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: AY029258.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAAGCGTG TTTTCTCCCT GCTAGAAAAG TCTTGGCTTG GTGCTCCGAT ACAATTTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_700440.2 |
CDS | 60..4085 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAAGCGTG TTTTCTCCCT GCTAGAAAAG TCTTGGCTTG GTGCTCCGAT ACAATTTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu84022 | |
Clone ID Related Accession (Same CDS sequence) | NM_001359880.1 | |
Accession Version | NM_001359880.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3066bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-25 | |
Organism | Mus musculus(house mouse) | |
Product | WD repeat-containing protein 19 isoform a | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC132222.3, AK052303.1 and AC138654.4. Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence conpared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a. ##Evidence-Data-START## Transcript exon combination :: AK052303.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849381, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAAGCGTG TTTTCTCCCT GCTAGAAAAG TCTTGGCTTG GTGCTCCGAT ACAATTTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001346809.1 |
CDS | 60..3125 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAAGCGTG TTTTCTCCCT GCTAGAAAAG TCTTGGCTTG GTGCTCCGAT ACAATTTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu22328 | |
Clone ID Related Accession (Same CDS sequence) | XM_011240713.1 , NM_001359879.1 , NM_153391.2 | |
Accession Version | XM_011240713.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4026bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | WD repeat-containing protein 19 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000071.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAGCGTG TTTTCTCCCT GCTAGAAAAG TCTTGGCTTG GTGCTCCGAT ACAATTTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011239015.1 |
CDS | 98..4123 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAAGCGTG TTTTCTCCCT GCTAGAAAAG TCTTGGCTTG GTGCTCCGAT ACAATTTGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Primary cilia function regulates the length of the embryonic trunk axis and urogenital field in mice. |
The BBSome controls IFT assembly and turnaround in cilia. |
The IFT-A complex regulates Shh signaling through cilia structure and membrane protein trafficking. |
Mutations in mouse Ift144 model the craniofacial, limb and rib defects in skeletal ciliopathies. |
TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia. |