Gene Symbol | Micu1 |
Entrez Gene ID | 216001 |
Full Name | mitochondrial calcium uptake 1 |
Synonyms | C730016L05Rik,Calc,Cbara1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Micu1 cDNA ORF clone
Gene Symbol | Micu1 |
Entrez Gene ID | 216001 |
Full Name | mitochondrial calcium uptake 1 |
Synonyms | C730016L05Rik,Calc,Cbara1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_144822.3 | NP_659071.1 | calcium uptake protein 1, mitochondrial isoform 3 |
XM_006513471.2 | XP_006513534.1 | calcium uptake protein 1, mitochondrial isoform X1 |
NM_001359267.1 | NP_001346196.1 | calcium uptake protein 1, mitochondrial isoform 4 |
NM_001291442.1 | NP_001278371.1 | calcium uptake protein 1, mitochondrial isoform 1 |
NM_001291443.1 | NP_001278372.1 | calcium uptake protein 1, mitochondrial isoform 2 |
Homo sapiens (human) | MICU1 | NP_001182447.1 |
Pan troglodytes (chimpanzee) | MICU1 | XP_003339234.1 |
Canis lupus familiaris (dog) | MICU1 | XP_005619058.1 |
Bos taurus (cattle) | MICU1 | NP_001068806.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP009117 | XP_319870.3 |
Caenorhabditis elegans (roundworm) | micu-1 | NP_001255723.1 |
Oryza sativa (rice) | Os02g0613000 | NP_001047417.1 |
Xenopus tropicalis (tropical clawed frog) | micu1 | NP_001106411.2 |
Gallus gallus (chicken) | MICU1 | XP_001231722.3 |
Drosophila melanogaster (fruit fly) | CG4495 | NP_001097110.1 |
Oryza sativa (rice) | Os04g0502900 | NP_001053237.1 |
Mus musculus (house mouse) | Micu1 | NP_659071.1 |
Rattus norvegicus (Norway rat) | Micu1 | NP_955444.1 |
Danio rerio (zebrafish) | micu1 | NP_001077302.1 |
LOC708654 | XP_001104987.2 | |
Arabidopsis thaliana (thale cress) | AT4G32060 | NP_194934.1 |
MICU1 protects against myocardial ischemia/reperfusion injury and its control by the importer receptor Tom70.
Xue Q, Pei H, Liu Q, Zhao M, Sun J, Gao E, Ma X, Tao L
Cell death & disease8(7)e2923(2017 Jul)
MICU1 Alleviates Diabetic Cardiomyopathy Through Mitochondrial Ca
Ji L, Liu F, Jing Z, Huang Q, Zhao Y, Cao H, Li J, Yin C, Xing J, Li F
Diabetes66(6)1586-1600(2017 06)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
MICU1 was downregulated in db/db mouse hearts, which contributes to myocardial apoptosis in diabetes. Importantly, the reconstitution of MICU1 in diabetic hearts significantly inhibited the development of diabetic cardiomyopathy, as evidenced by enhanced cardiac function and reduced cardiac hypertrophy and myocardial fibrosis in db/db mice.
Title: MICU1 Alleviates Diabetic Cardiomyopathy Through Mitochondrial Ca
a possible role for tissue-specific stoichiometry between the Ca(2+)-sensing regulators (MICUs) and pore unit (MCU) of the uniporter, was investigated.
Title: Tissue-Specific Mitochondrial Decoding of Cytoplasmic Ca
A MICU1 splice variant confers high sensitivity to the mitochondrial Ca(2+) uptake machinery of skeletal muscle.
Title: A MICU1 Splice Variant Confers High Sensitivity to the Mitochondrial Ca
that MICU1 serves as a molecular gatekeeper preventing calcium overload and suggests that modulating the calcium uniporter could have widespread therapeutic benefits
Title: MICU1 Serves as a Molecular Gatekeeper to Prevent In?Vivo Mitochondrial Calcium Overload.
MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and liver regeneration.
Title: MICU1 regulation of mitochondrial Ca(2+) uptake dictates survival and tissue regeneration.
The following Micu1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Micu1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu20311 | |
Clone ID Related Accession (Same CDS sequence) | NM_144822.3 | |
Accession Version | NM_144822.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1434bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | calcium uptake protein 1, mitochondrial isoform 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC155827.10, AK050113.1 and AC155939.6. On Apr 16, 2014 this sequence version replaced NM_144822.2. Transcript Variant: This variant (3) lacks two alternate exons in the coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK049521.1, AK050113.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTTTCGTC TTAACACCCT TTCTGCGTTG GCAGAACTAG CTGTGGGCTC TCGCTGGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_659071.1 |
CDS | 127..1560 |
Translation |
Target ORF information:
Target ORF information:
|
NM_144822.3 |
1 | ATGTTTCGTC TTAACACCCT TTCTGCGTTG GCAGAACTAG CTGTGGGCTC TCGCTGGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu20353 | |
Clone ID Related Accession (Same CDS sequence) | NM_001291442.1 | |
Accession Version | NM_001291442.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1452bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | calcium uptake protein 1, mitochondrial isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC155827.10, AK046049.1 and AC155939.6. On Apr 16, 2014 this sequence version replaced XM_006513469.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK046049.1, SRR1660821.124427.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164132 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTTTCGTC TTAACACCCT TTCTGCGTTG GCAGAACTAG CTGTGGGCTC TCGCTGGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001278371.1 |
CDS | 127..1578 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001291442.1 |
1 | ATGTTTCGTC TTAACACCCT TTCTGCGTTG GCAGAACTAG CTGTGGGCTC TCGCTGGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu44375 | |
Clone ID Related Accession (Same CDS sequence) | XM_006513471.2 , NM_001359267.1 | |
Accession Version | NM_001359267.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1440bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-28 | |
Organism | Mus musculus(house mouse) | |
Product | calcium uptake protein 1, mitochondrial isoform 4 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC155827.10, AK050113.1, CX240738.1 and AC155939.6. On Dec 29, 2017 this sequence version replaced XM_006513471.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660815.55380.1, SRR1660813.248006.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTTTCGTC TTAACACCCT TTCTGCGTTG GCAGAACTAG CTGTGGGCTC TCGCTGGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001346196.1 |
CDS | 127..1566 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001359267.1 |
1 | ATGTTTCGTC TTAACACCCT TTCTGCGTTG GCAGAACTAG CTGTGGGCTC TCGCTGGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu44375 | |
Clone ID Related Accession (Same CDS sequence) | XM_006513471.2 , NM_001359267.1 | |
Accession Version | XM_006513471.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1440bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(House mouse) | |
Product | calcium uptake protein 1, mitochondrial isoform X1 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006513471.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTTCGTC TTAACACCCT TTCTGCGTTG GCAGAACTAG CTGTGGGCTC TCGCTGGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006513534.1 |
CDS | 208..1647 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006513471.2 |
1 | ATGTTTCGTC TTAACACCCT TTCTGCGTTG GCAGAACTAG CTGTGGGCTC TCGCTGGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu20444 | |
Clone ID Related Accession (Same CDS sequence) | NM_001291443.1 | |
Accession Version | NM_001291443.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | calcium uptake protein 1, mitochondrial isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC155827.10, BC023022.1 and AC155939.6. On Apr 16, 2014 this sequence version replaced XM_006513470.1. Transcript Variant: This variant (2) lacks an alternate exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660811.2199.1, BC023022.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTTTCGTC TTAACACCCT TTCTGCGTTG GCAGAACTAG CTGTGGGCTC TCGCTGGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001278372.1 |
CDS | 127..1572 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001291443.1 |
1 | ATGTTTCGTC TTAACACCCT TTCTGCGTTG GCAGAACTAG CTGTGGGCTC TCGCTGGTAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
MICU1 protects against myocardial ischemia/reperfusion injury and its control by the importer receptor Tom70. |
MICU1 Alleviates Diabetic Cardiomyopathy Through Mitochondrial Ca |