Gene Symbol | Efemp1 |
Entrez Gene ID | 216616 |
Full Name | epidermal growth factor-containing fibulin-like extracellular matrix protein 1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Efemp1 cDNA ORF clone
gRNAs
Gene Symbol | Efemp1 |
Entrez Gene ID | 216616 |
Full Name | epidermal growth factor-containing fibulin-like extracellular matrix protein 1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_146015.2 | NP_666127.2 | EGF-containing fibulin-like extracellular matrix protein 1 precursor |
XM_030245798.1 | XP_030101658.1 | EGF-containing fibulin-like extracellular matrix protein 1 isoform X2 |
XM_030245799.1 | XP_030101659.1 | EGF-containing fibulin-like extracellular matrix protein 1 isoform X3 |
XM_011243695.1 | XP_011241997.1 | EGF-containing fibulin-like extracellular matrix protein 1 isoform X2 |
XM_011243696.1 | XP_011241998.1 | EGF-containing fibulin-like extracellular matrix protein 1 isoform X3 |
XM_006514660.1 | XP_006514723.1 | EGF-containing fibulin-like extracellular matrix protein 1 isoform X1 |
Canis lupus familiaris (dog) | EFEMP1 | XP_005626175.1 |
Gallus gallus (chicken) | EFEMP1 | XP_426097.3 |
Danio rerio (zebrafish) | LOC100332567 | XP_002664117.2 |
Mus musculus (house mouse) | Efemp1 | NP_666127.2 |
Homo sapiens (human) | EFEMP1 | NP_001034438.1 |
Bos taurus (cattle) | EFEMP1 | NP_001075186.1 |
Rattus norvegicus (Norway rat) | Efemp1 | NP_001012039.1 |
Xenopus tropicalis (tropical clawed frog) | efemp1 | XP_002936872.1 |
TWEAK promotes migration and invasion in MEFs through a mechanism dependent on ERKs activation and Fibulin 3 down-regulation.
Sequera C, V?zquez-Carballo A, Arechederra M, Fern?ndez-Veledo S, Porras A
Journal of cellular physiology233(2)968-978(2018 Feb)
Mutant Fibulin-3 Causes Proteoglycan Accumulation and Impaired Diffusion Across Bruch's Membrane.
Zayas-Santiago A, Cross SD, Stanton JB, Marmorstein AD, Marmorstein LY
Investigative ophthalmology & visual science58(7)3046-3054(2017 Jun)
Deletion of Efemp1 Is Protective Against the Development of Sub-RPE Deposits in Mouse Eyes.
Stanton JB, Marmorstein AD, Zhang Y, Marmorstein LY
Investigative ophthalmology & visual science58(3)1455-1461(2017 03)
Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression.
Naba A, Clauser KR, Mani DR, Carr SA, Hynes RO
Scientific reports740495(2017 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
TWEAK promotes migration and invasion in murine embryonic fibroblasts through a mechanism dependent on ERKs activation and Fibulin 3 down-regulation.
Title: TWEAK promotes migration and invasion in MEFs through a mechanism dependent on ERKs activation and Fibulin 3 down-regulation.
Mutant fibulin-3 causes proteoglycan accumulation, reduction of MMP-2 and MMP-9, but increase of TIMP-3, and impairs diffusion across Bruch's membrane.
Title: Mutant Fibulin-3 Causes Proteoglycan Accumulation and Impaired Diffusion Across Bruch's Membrane.
Define the Efemp1-p27(Kip1) axis as a potential marker module of PDAC cell sensitivity towards dual PI3K-mTOR inhibitors.
Title: Efemp1 and p27(Kip1) modulate responsiveness of pancreatic cancer cells towards a dual PI3K/mTOR inhibitor in preclinical models.
Data suggest a role for fibulin-3 in tissue maintenance and regeneration in the adult olfactory pathway.
Title: Lack of fibulin-3 alters regenerative tissue responses in the primary olfactory pathway.
both fibulin-3 and -5 are important in maintaining pelvic organ support in mice.
Title: Failure of pelvic organ support in mice deficient in fibulin-3.
The following Efemp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Efemp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu12132 | |
Clone ID Related Accession (Same CDS sequence) | NM_146015.2 , XM_006514660.1 | |
Accession Version | NM_146015.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1482bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Mus musculus(house mouse) | |
Product | EGF-containing fibulin-like extracellular matrix protein 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK077302.1 and AY251056.1. On Jan 11, 2008 this sequence version replaced NM_146015.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY251056.1, AK077302.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTTGCAAA CACTTTTCCT AACTATGCTG ACTCTGGCGC TGGTCAAGTC ACAGTACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_666127.2 |
CDS | 130..1611 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGTTGCAAA CACTTTTCCT AACTATGCTG ACTCTGGCGC TGGTCAAGTC ACAGTACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu12132 | |
Clone ID Related Accession (Same CDS sequence) | NM_146015.2 , XM_006514660.1 | |
Accession Version | XM_006514660.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1482bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | EGF-containing fibulin-like extracellular matrix protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTGCAAA CACTTTTCCT AACTATGCTG ACTCTGGCGC TGGTCAAGTC ACAGTACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006514723.1 |
CDS | 113..1594 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGTTGCAAA CACTTTTCCT AACTATGCTG ACTCTGGCGC TGGTCAAGTC ACAGTACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu72977 | |
Clone ID Related Accession (Same CDS sequence) | XM_030245798.1 , XM_011243695.1 | |
Accession Version | XM_011243695.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1362bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | EGF-containing fibulin-like extracellular matrix protein 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTGCAAA CACTTTTCCT AACTATGCTG ACTCTGGCGC TGGTCAAGTC ACAGTACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011241997.1 |
CDS | 10..1371 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTTGCAAA CACTTTTCCT AACTATGCTG ACTCTGGCGC TGGTCAAGTC ACAGTACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu72978 | |
Clone ID Related Accession (Same CDS sequence) | XM_030245799.1 , XM_011243696.1 | |
Accession Version | XM_011243696.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1095bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | EGF-containing fibulin-like extracellular matrix protein 1 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTGCAAA CACTTTTCCT AACTATGCTG ACTCTGGCGC TGGTCAAGTC ACAGTACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011241998.1 |
CDS | 10..1104 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTTGCAAA CACTTTTCCT AACTATGCTG ACTCTGGCGC TGGTCAAGTC ACAGTACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu72977 | |
Clone ID Related Accession (Same CDS sequence) | XM_030245798.1 , XM_011243695.1 | |
Accession Version | XM_030245798.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1362bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | EGF-containing fibulin-like extracellular matrix protein 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTGCAAA CACTTTTCCT AACTATGCTG ACTCTGGCGC TGGTCAAGTC ACAGTACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030101658.1 |
CDS | 181..1542 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTTGCAAA CACTTTTCCT AACTATGCTG ACTCTGGCGC TGGTCAAGTC ACAGTACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu72978 | |
Clone ID Related Accession (Same CDS sequence) | XM_030245799.1 , XM_011243696.1 | |
Accession Version | XM_030245799.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1095bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | EGF-containing fibulin-like extracellular matrix protein 1 isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTGCAAA CACTTTTCCT AACTATGCTG ACTCTGGCGC TGGTCAAGTC ACAGTACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030101659.1 |
CDS | 157..1251 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTTGCAAA CACTTTTCCT AACTATGCTG ACTCTGGCGC TGGTCAAGTC ACAGTACACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
TWEAK promotes migration and invasion in MEFs through a mechanism dependent on ERKs activation and Fibulin 3 down-regulation. |
Mutant Fibulin-3 Causes Proteoglycan Accumulation and Impaired Diffusion Across Bruch's Membrane. |
Deletion of Efemp1 Is Protective Against the Development of Sub-RPE Deposits in Mouse Eyes. |
Quantitative proteomic profiling of the extracellular matrix of pancreatic islets during the angiogenic switch and insulinoma progression. |