Gene Symbol | Nle1 |
Entrez Gene ID | 217011 |
Full Name | notchless homolog 1 |
Synonyms | AL022765,BC018399,Nle,l11Jus1,l11Jus4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Nle1 cDNA ORF clone
gRNAs
Gene Symbol | Nle1 |
Entrez Gene ID | 217011 |
Full Name | notchless homolog 1 |
Synonyms | AL022765,BC018399,Nle,l11Jus1,l11Jus4 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_030245842.1 | XP_030101702.1 | notchless protein homolog 1 isoform X1 |
XM_006532975.2 | XP_006533038.1 | notchless protein homolog 1 isoform X1 |
XM_006532976.2 | XP_006533039.1 | notchless protein homolog 1 isoform X2 |
NM_145431.2 | NP_663406.2 | notchless protein homolog 1 |
XM_006532976.3 | XP_006533039.1 | notchless protein homolog 1 isoform X2 |
Pan troglodytes (chimpanzee) | NLE1 | XP_001174396.2 |
NLE1 | XP_001113853.1 | |
Mus musculus (house mouse) | Nle1 | NP_663406.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP002221 | XP_307962.4 |
Schizosaccharomyces pombe (fission yeast) | SPCC18.05c | NP_588384.1 |
Neurospora crassa | NCU00794 | XP_964950.1 |
Rattus norvegicus (Norway rat) | Nle1 | NP_001121006.1 |
Caenorhabditis elegans (roundworm) | W07E6.2 | NP_493745.1 |
Kluyveromyces lactis | KLLA0C08547g | XP_452581.1 |
Eremothecium gossypii | AGOS_AER263C | NP_985120.1 |
Homo sapiens (human) | NLE1 | NP_060566.2 |
Canis lupus familiaris (dog) | NLE1 | XP_005624858.1 |
Danio rerio (zebrafish) | nle1 | NP_001018418.1 |
Drosophila melanogaster (fruit fly) | Nle | NP_477294.2 |
Gallus gallus (chicken) | NLE1 | XP_415857.3 |
Saccharomyces cerevisiae (baker's yeast) | RSA4 | NP_009997.2 |
Oryza sativa (rice) | Os11g0594200 | NP_001068204.1 |
Bos taurus (cattle) | NLE1 | NP_001014887.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_08708 | XP_003719269.1 |
Arabidopsis thaliana (thale cress) | AT5G52820 | NP_200094.1 |
Oryza sativa (rice) | Os10g0104500 | NP_001064020.1 |
Xenopus tropicalis (tropical clawed frog) | nle1 | NP_001072540.1 |
Ribosome biogenesis dysfunction leads to p53-mediated apoptosis and goblet cell differentiation of mouse intestinal stem/progenitor cells.
Stedman A, Beck-Cormier S, Le Bouteiller M, Raveux A, Vandormael-Pournin S, Coqueran S, Lejour V, Jarzebowski L, Toledo F, Robine S, Cohen-Tannoudji M
Cell death and differentiation22(11)1865-76(2015 Nov)
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Thompson CL, Ng L, Menon V, Martinez S, Lee CK, Glattfelder K, Sunkin SM, Henry A, Lau C, Dang C, Garcia-Lopez R, Martinez-Ferre A, Pombero A, Rubenstein JLR, Wakeman WB, Hohmann J, Dee N, Sodt AJ, Young R, Smith K, Nguyen TN, Kidney J, Kuan L, Jeromin A, Kaykas A, Miller J, Page D, Orta G, Bernard A, Riley Z, Smith S, Wohnoutka P, Hawrylycz MJ, Puelles L, Jones AR
Neuron83(2)309-323(2014 Jul)
Notchless is required for axial skeleton formation in mice.
Beck-Cormier S, Escande M, Souilhol C, Vandormael-Pournin S, Sourice S, Pilet P, Babinet C, Cohen-Tannoudji M
PloS one9(5)e98507(2014)
Loss of Dlg-1 in the mouse lens impairs fibroblast growth factor receptor signaling.
Lee S, Griep AE
PloS one9(5)e97470(2014)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These data demonstrate an essential role for Nle1 during organogenesis and in particular during axial development.
Title: Notchless is required for axial skeleton formation in mice.
These indings establish an essential role for Nle in hematopoietic stem cells.
Title: Notchless-dependent ribosome synthesis is required for the maintenance of adult hematopoietic stem cells.
mNle is mainly required in inner cell mass cells, being instrumental for their survival, and raise the possibility that the death of mNle-deficient embryos might result from abnormal Notch signaling during the first steps of development.
Title: The murine ortholog of notchless, a direct regulator of the notch pathway in Drosophila melanogaster, is essential for survival of inner cell mass cells.
The following Nle1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nle1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu22561 | |
Clone ID Related Accession (Same CDS sequence) | NM_145431.2 | |
Accession Version | NM_145431.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1458bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-23 | |
Organism | Mus musculus(house mouse) | |
Product | notchless protein homolog 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY149184.1, AK141230.1, AI852473.1 and BX631936.1. On May 29, 2009 this sequence version replaced NM_145431.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC018399.1, AK170853.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164138 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCGGCGG CGGTGGTGGA AGAGGCGGCG GCAGGCGACG TGCAGCGGCT GCTCGTACAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_663406.2 |
CDS | 40..1497 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCGGCGG CGGTGGTGGA AGAGGCGGCG GCAGGCGACG TGCAGCGGCT GCTCGTACAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu46080 | |
Clone ID Related Accession (Same CDS sequence) | XM_006532975.2 | |
Accession Version | XM_006532975.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 966bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | notchless protein homolog 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006532975.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGGCGG CGGTGGTGGA AGAGGCGGCG GCAGGCGACG TGCAGCGGCT GCTCGTACAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006533038.1 |
CDS | 90..1055 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGGCGG CGGTGGTGGA AGAGGCGGCG GCAGGCGACG TGCAGCGGCT GCTCGTACAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu46081 | |
Clone ID Related Accession (Same CDS sequence) | XM_006532976.2 , XM_006532976.3 | |
Accession Version | XM_006532976.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | notchless protein homolog 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006532976.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGGCGG CGGTGGTGGA AGAGGCGGCG GCAGGCGACG TGCAGCGGCT GCTCGTACAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006533039.1 |
CDS | 90..938 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGGCGG CGGTGGTGGA AGAGGCGGCG GCAGGCGACG TGCAGCGGCT GCTCGTACAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu46081 | |
Clone ID Related Accession (Same CDS sequence) | XM_006532976.2 , XM_006532976.3 | |
Accession Version | XM_006532976.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 849bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | notchless protein homolog 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006532976.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCGGCGG CGGTGGTGGA AGAGGCGGCG GCAGGCGACG TGCAGCGGCT GCTCGTACAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006533039.1 |
CDS | 91..939 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCGGCGG CGGTGGTGGA AGAGGCGGCG GCAGGCGACG TGCAGCGGCT GCTCGTACAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu85731 | |
Clone ID Related Accession (Same CDS sequence) | XM_030245842.1 | |
Accession Version | XM_030245842.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | notchless protein homolog 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGAGTC TGTTCCCAGA AGATGGTTGG CTAGGCAGCA GGAATACCCA TGCGCAGTGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030101702.1 |
CDS | 408..1595 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGAGTC TGTTCCCAGA AGATGGTTGG CTAGGCAGCA GGAATACCCA TGCGCAGTGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Ribosome biogenesis dysfunction leads to p53-mediated apoptosis and goblet cell differentiation of mouse intestinal stem/progenitor cells. |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
Notchless is required for axial skeleton formation in mice. |
Loss of Dlg-1 in the mouse lens impairs fibroblast growth factor receptor signaling. |