Nr2e1 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Nr2e1 |
| Entrez Gene ID | 21907 |
| Full Name | nuclear receptor subfamily 2, group E, member 1 |
| Synonyms | Mtl1,Mtll,TLL,Tlx,XTLL,fierce,frc,tailless |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| XM_006512701.2 | XP_006512764.1 | nuclear receptor subfamily 2 group E member 1 isoform X1 |
| NM_152229.3 | NP_689415.1 | nuclear receptor subfamily 2 group E member 1 |
| NM_152229.2 | NP_689415.1 | nuclear receptor subfamily 2 group E member 1 |
| NR2E1 | XP_001094659.1 | |
| Bos taurus (cattle) | NR2E1 | NP_001179582.1 |
| Mus musculus (house mouse) | Nr2e1 | NP_689415.1 |
| Danio rerio (zebrafish) | nr2e1 | NP_001003608.1 |
| Homo sapiens (human) | NR2E1 | NP_003260.1 |
| Canis lupus familiaris (dog) | NR2E1 | XP_532253.2 |
| Caenorhabditis elegans (roundworm) | nhr-67 | NP_502094.1 |
| Drosophila melanogaster (fruit fly) | dsf | NP_477140.1 |
| Xenopus tropicalis (tropical clawed frog) | nr2e1 | XP_002937209.2 |
| Pan troglodytes (chimpanzee) | NR2E1 | XP_527467.2 |
| Gallus gallus (chicken) | NR2E1 | NP_990501.1 |
| Rattus norvegicus (Norway rat) | Nr2e1 | NP_001106668.1 |
Related articles in PubMed
Deletion of TLX and social isolation impairs exercise-induced neurogenesis in the adolescent hippocampus.
Kozareva DA, O'Leary OF, Cryan JF, Nolan YM
Hippocampus28(1)3-11(2018 Jan)
Nr2e1 Downregulation Is Involved in Excess Retinoic Acid-induced Developmental Abnormality in the Mouse Brain.
Yu J, Guo Q, Mu JB, Zhang T, Li RK, Xie J
Biomedical and environmental sciences : BES30(3)185-193(2017 Mar)
Co-activator candidate interactions for orphan nuclear receptor NR2E1.
Corso-D?az X, de Leeuw CN, Alonso V, Melchers D, Wong BK, Houtman R, Simpson EM
BMC genomics17(1)832(2016 10)
Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons.
Sandberg M, Flandin P, Silberberg S, Su-Feher L, Price JD, Hu JS, Kim C, Visel A, Nord AS, Rubenstein JLR
Neuron91(6)1260-1275(2016 Sep)
The nuclear receptor Tlx regulates motor, cognitive and anxiety-related behaviours during adolescence and adulthood.
O'Leary JD, Kozareva DA, Hueston CM, O'Leary OF, Cryan JF, Nolan YM
Behavioural brain research30636-47(2016 06)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
This study demonstrated that Nr2e1 could be regulated by retinoic acid, which would aid a better understanding of the mechanism underlying RA-induced brain abnormality.
Title: Nr2e1 Downregulation Is Involved in Excess Retinoic Acid-induced Developmental Abnormality in the Mouse Brain.
This study demonstrated that deletion of Tlx impairs motor, cognitive and anxiety-related behaviours during adolescence and adulthood in male and female mice with most effects occurring during adolescence rather than adulthood, independent of housing conditions.
Title: The nuclear receptor Tlx regulates motor, cognitive and anxiety-related behaviours during adolescence and adulthood.
TLX, an essential regulator of NSC proliferation and self-renewal, inhibits miR-219 processing. miR-219 suppresses mouse NSC proliferation downstream of TLX.
Title: The TLX-miR-219 cascade regulates neural stem cell proliferation in neurodevelopment and schizophrenia iPSC model.
Nr2e1 deficiency augments palmitate-induced oxidative stress. Nr2e1 deficiency also resulted in decreases in antioxidant enzymes and expression level of Nrf2.
Title: Nr2e1 Deficiency Augments Palmitate-Induced Oxidative Stress in Beta Cells.
TLX is essential for SOX2-mediated in vivo reprogramming of astrocytes and itself is also sufficient to induce neurogenesis in the adult striatum.
Title: Enhancer Analysis Unveils Genetic Interactions between TLX and SOX2 in Neural Stem Cells and In Vivo Reprogramming.
The following Nr2e1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nr2e1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu43854 | |
| Clone ID Related Accession (Same CDS sequence) | XM_006512701.2 | |
| Accession Version | XM_006512701.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1146bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-07 | |
| Organism | Mus musculus(house mouse) | |
| Product | nuclear receptor subfamily 2 group E member 1 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006512701.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGGAAAAT CAGGCCGCAT TTTAGATATC CCTTGCAAAG TGTGTGGTGA CCGCAGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_006512764.1 |
| CDS | 16..1161 |
| Translation |
Target ORF information:
Target ORF information:
|
 XM_006512701.2 |
ORF Insert Sequence:
1 | ATGGGAAAAT CAGGCCGCAT TTTAGATATC CCTTGCAAAG TGTGTGGTGA CCGCAGCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu02333 | |
| Clone ID Related Accession (Same CDS sequence) | NM_152229.3 , NM_152229.2 | |
| Accession Version | NM_152229.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1158bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-30 | |
| Organism | Mus musculus(house mouse) | |
| Product | nuclear receptor subfamily 2 group E member 1 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC166260.7. On Jun 23, 2018 this sequence version replaced NM_152229.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC057104.1, AK132201.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849384 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGAGCAAGC CCGCCGGATC AACAAGCCGC ATTTTAGATA TCCCTTGCAA AGTGTGTGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_689415.1 |
| CDS | 685..1842 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_152229.3 |
ORF Insert Sequence:
1 | ATGAGCAAGC CCGCCGGATC AACAAGCCGC ATTTTAGATA TCCCTTGCAA AGTGTGTGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu02333 | |
| Clone ID Related Accession (Same CDS sequence) | NM_152229.3 , NM_152229.2 | |
| Accession Version | NM_152229.2 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1158bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-12-27 | |
| Organism | Mus musculus(house mouse) | |
| Product | nuclear receptor subfamily 2 group E member 1 | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC166260.7. On Mar 21, 2007 this sequence version replaced NM_152229.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC057104.1, AK132201.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849384 [ECO:0000350] ##Evidence-Data-END## | |
1 | ATGAGCAAGC CCGCCGGATC AACAAGCCGC ATTTTAGATA TCCCTTGCAA AGTGTGTGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_689415.1 |
| CDS | 683..1840 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_152229.2 |
ORF Insert Sequence:
1 | ATGAGCAAGC CCGCCGGATC AACAAGCCGC ATTTTAGATA TCCCTTGCAA AGTGTGTGGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Deletion of TLX and social isolation impairs exercise-induced neurogenesis in the adolescent hippocampus. |
|
Nr2e1 Downregulation Is Involved in Excess Retinoic Acid-induced Developmental Abnormality in the Mouse Brain. |
|
Co-activator candidate interactions for orphan nuclear receptor NR2E1. |
|
Transcriptional Networks Controlled by NKX2-1 in the Development of Forebrain GABAergic Neurons. |
|
The nuclear receptor Tlx regulates motor, cognitive and anxiety-related behaviours during adolescence and adulthood. |