Gene Symbol | Vnn1 |
Entrez Gene ID | 22361 |
Full Name | vanin 1 |
Synonyms | V-1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Vnn1 cDNA ORF clone
gRNAs
Gene Symbol | Vnn1 |
Entrez Gene ID | 22361 |
Full Name | vanin 1 |
Synonyms | V-1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006512718.2 | XP_006512781.1 | pantetheinase isoform X1 |
NM_011704.3 | NP_035834.2 | pantetheinase precursor |
Pan troglodytes (chimpanzee) | VNN1 | XP_001169280.1 |
Mus musculus (house mouse) | Vnn1 | NP_035834.2 |
Xenopus tropicalis (tropical clawed frog) | vnn1 | XP_004914646.1 |
Homo sapiens (human) | VNN1 | NP_004657.2 |
Rattus norvegicus (Norway rat) | Vnn1 | NP_001020794.1 |
Gallus gallus (chicken) | VNN1 | NP_001034377.1 |
Canis lupus familiaris (dog) | VNN1 | NP_001003372.1 |
Bos taurus (cattle) | VNN1 | NP_001019727.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012357 | XP_320200.4 |
Xenopus tropicalis (tropical clawed frog) | vnn2 | NP_001011263.1 |
VNN1 | XP_001102153.1 |
Imbalance of the Vanin-1 Pathway in Systemic Sclerosis.
Kavian N, Mehlal S, Marut W, Servettaz A, Giessner C, Bourges C, Nicco C, Ch?reau C, Lemar?chal H, Dutilh MF, Cerles O, Guilpain P, Vuiblet V, Chouzenoux S, Galland F, Quere I, Weill B, Naquet P, Batteux F
Journal of immunology (Baltimore, Md. : 1950)197(8)3326-3335(2016 Oct)
VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet.
Hu YW, Wu SG, Zhao JJ, Ma X, Lu JB, Xiu JC, Zhang Y, Huang C, Qiu YR, Sha YH, Gao JJ, Wang YC, Li SF, Zhao JY, Zheng L, Wang Q
Journal of lipid research57(8)1398-411(2016 08)
Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes.
van Diepen JA, Jansen PA, Ballak DB, Hijmans A, Rutjes FP, Tack CJ, Netea MG, Schalkwijk J, Stienstra R
Scientific reports621906(2016 Mar)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The data demonstrate that vanin-1/pantetheinase controls fibrosis, vasculopathy, autoimmunity, and oxidative stress in Systemic sclerosis (SSc).
Title: Imbalance of the Vanin-1 Pathway in Systemic Sclerosis.
oxidized LDL (Ox-LDL) can significantly induce VNN1 expression through an ERK1/2/cyclooxygenase-2 (COX-2)/PPARalpha signaling pathway.
Title: VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet.
absence of vanin-1 activity improves insulin sensitivity.
Title: Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes.
serum pantetheinas, encoded by the VNN1 gene, level regulates erythrocyte life span and modulates the risk of developing complicated malaria.
Title: Serum pantetheinase/vanin levels regulate erythrocyte homeostasis and severity of malaria.
Data indicate that genetic ablation of the Vanin-1 (Vnn1) gene in SF-1 (NR5A1) transgenic mice significantly reduced the severity of neoplastic lesions in the adrenal cortex.
Title: Vanin-1 inactivation antagonizes the development of adrenocortical neoplasia in Sf-1 transgenic mice.
The following Vnn1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vnn1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu43866 | |
Clone ID Related Accession (Same CDS sequence) | XM_006512718.2 | |
Accession Version | XM_006512718.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1119bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | pantetheinase isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 9, 2015 this sequence version replaced XM_006512718.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGGAGACA AGAAGCCGTG TAACACCAGC GACTCTCACT GTCCACCTGA CGGCAGATTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006512781.1 |
CDS | 141..1259 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGGAGACA AGAAGCCGTG TAACACCAGC GACTCTCACT GTCCACCTGA CGGCAGATTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu22513 | |
Clone ID Related Accession (Same CDS sequence) | NM_011704.3 | |
Accession Version | NM_011704.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1539bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-26 | |
Organism | Mus musculus(house mouse) | |
Product | pantetheinase precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB838710.1 and AK145984.1. On Jul 8, 2009 this sequence version replaced NM_011704.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK145984.1, AK002773.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGGCATGT CTTGGTGGCT GGCGTGTGCT GCAGCGTTTT CTGCCCTCTG TGTCTTAAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_035834.2 |
CDS | 189..1727 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGGCATGT CTTGGTGGCT GGCGTGTGCT GCAGCGTTTT CTGCCCTCTG TGTCTTAAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Imbalance of the Vanin-1 Pathway in Systemic Sclerosis. |
VNN1 promotes atherosclerosis progression in apoE-/- mice fed a high-fat/high-cholesterol diet. |
Genetic and pharmacological inhibition of vanin-1 activity in animal models of type 2 diabetes. |