Gene Symbol | Wap |
Entrez Gene ID | 22373 |
Full Name | whey acidic protein |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Wap cDNA ORF clone
gRNAs
Gene Symbol | Wap |
Entrez Gene ID | 22373 |
Full Name | whey acidic protein |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_017314502.2 | XP_017169991.1 | whey acidic protein isoform X1 |
NM_011709.5 | NP_035839.3 | whey acidic protein precursor |
XM_017314502.1 | XP_017169991.1 | whey acidic protein isoform X1 |
The DNA resection protein CtIP promotes mammary tumorigenesis.
Reczek CR, Shakya R, Miteva Y, Szabolcs M, Ludwig T, Baer R
Oncotarget7(22)32172-83(2016 May)
Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy.
Stratikopoulos EE, Dendy M, Szabolcs M, Khaykin AJ, Lefebvre C, Zhou MM, Parsons R
Cancer cell27(6)837-51(2015 Jun)
Therapeutic effects of an anti-Myc drug on mouse pancreatic cancer.
Stellas D, Szabolcs M, Koul S, Li Z, Polyzos A, Anagnostopoulos C, Cournia Z, Tamvakopoulos C, Klinakis A, Efstratiadis A
Journal of the National Cancer Institute106(12)(2014 Dec)
Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis.
Schmidt JW, Wehde BL, Sakamoto K, Triplett AA, Anderson SM, Tsichlis PN, Leone G, Wagner KU
Molecular and cellular biology34(7)1363-77(2014 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data show demonstrated that the Wap-rtTA knockin allele allows a tightly controlled temporal and spatial expression of transgenes in the mammary gland in a ligand-inducible manneer.
Title: Longitudinal analysis of mammogenesis using a novel tetracycline-inducible mouse model and in vivo imaging.
milk protein genes are subject to nuclear repositioning when activated, in agreement with a role for nuclear architecture in gene regulation, but that they behave differently as a function of their chromosomal context
Title: The nuclear localization of WAP and CSN genes is modified by lactogenic hormones in HC11 cells.
tight regulation of WAP gene expression parallels variations in the chromatin structure and DNA methylation profile throughout the Ramp3-WAP-Tbrg4 locus.
Title: Epigenetic modifications and chromatin loop organization explain the different expression profiles of the Tbrg4, WAP and Ramp3 genes.
Wap regulates the proliferation of mammary epithelial cells by preventing serine protease from degrading laminin.
Title: Whey acidic protein (WAP) regulates the proliferation of mammary epithelial cells by preventing serine protease from degrading laminin.
May be essential for adequate nourishment of growing young rodents, which triple in size within the first 10 days of lactation.
Title: Expression of the whey acidic protein (Wap) is necessary for adequate nourishment of the offspring but not functional differentiation of mammary epithelial cells.
The following Wap gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Wap cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu58585 | |
Clone ID Related Accession (Same CDS sequence) | NM_011709.5 | |
Accession Version | NM_011709.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 405bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-22 | |
Organism | Mus musculus(house mouse) | |
Product | whey acidic protein precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL603787.8. On Apr 28, 2007 this sequence version replaced NM_011709.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI108565.1, AK164735.1 [ECO:0000332] ##Evidence-Data-END## |
1 | ATGCGTTGCC TCATCAGCCT TGTTCTTGGC CTGCTGGCCC TGGAGGTGGC CCTCGCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_035839.3 |
CDS | 28..432 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGCGTTGCC TCATCAGCCT TGTTCTTGGC CTGCTGGCCC TGGAGGTGGC CCTCGCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu77880 | |
Clone ID Related Accession (Same CDS sequence) | XM_017314502.2 , XM_017314502.1 | |
Accession Version | XM_017314502.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | whey acidic protein isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_017314502.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 20% of CDS bases ##RefSeq-Attributes-END## |
1 | ATGCGTTGCC TCATCAGCCT TGTTCTTGGC CTGCTGGCCC TGGAGGTGGC CCTCGCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017169991.1 |
CDS | 33..533 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCGTTGCC TCATCAGCCT TGTTCTTGGC CTGCTGGCCC TGGAGGTGGC CCTCGCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu77880 | |
Clone ID Related Accession (Same CDS sequence) | XM_017314502.2 , XM_017314502.1 | |
Accession Version | XM_017314502.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 501bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | whey acidic protein isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000077.6) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## ##RefSeq-Attributes-START## ab initio :: 15% of CDS bases ##RefSeq-Attributes-END## |
1 | ATGCGTTGCC TCATCAGCCT TGTTCTTGGC CTGCTGGCCC TGGAGGTGGC CCTCGCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_017169991.1 |
CDS | 70..570 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCGTTGCC TCATCAGCCT TGTTCTTGGC CTGCTGGCCC TGGAGGTGGC CCTCGCTCAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The DNA resection protein CtIP promotes mammary tumorigenesis. |
Kinase and BET Inhibitors Together Clamp Inhibition of PI3K Signaling and Overcome Resistance to Therapy. |
Therapeutic effects of an anti-Myc drug on mouse pancreatic cancer. |
Stat5 regulates the phosphatidylinositol 3-kinase/Akt1 pathway during mammary gland development and tumorigenesis. |