Gene Symbol | Ccn4 |
Entrez Gene ID | 22402 |
Full Name | WNT1 inducible signaling pathway protein 1 |
Synonyms | AW146261,CCN4,Elm1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Ccn4 cDNA ORF clone
gRNAs
Gene Symbol | Ccn4 |
Entrez Gene ID | 22402 |
Full Name | WNT1 inducible signaling pathway protein 1 |
Synonyms | AW146261,CCN4,Elm1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_018865.2 | NP_061353.1 | WNT1-inducible-signaling pathway protein 1 precursor |
XM_006520889.2 | XP_006520952.1 | WNT1-inducible-signaling pathway protein 1 isoform X1 |
XM_006520889.1 | XP_006520952.1 | WNT1-inducible-signaling pathway protein 1 isoform X1 |
NM_018865.3 | NP_061353.1 | WNT1-inducible-signaling pathway protein 1 precursor |
Pan troglodytes (chimpanzee) | WISP1 | XP_528234.2 |
Bos taurus (cattle) | WISP1 | XP_002692649.2 |
Mus musculus (house mouse) | Wisp1 | NP_061353.1 |
Gallus gallus (chicken) | WISP1 | NP_001019750.1 |
WISP1 | XP_001087371.1 | |
Danio rerio (zebrafish) | wisp1a | NP_001159702.1 |
Danio rerio (zebrafish) | wisp1b | NP_001107100.1 |
Homo sapiens (human) | WISP1 | NP_003873.1 |
Canis lupus familiaris (dog) | WISP1 | XP_005628355.1 |
Rattus norvegicus (Norway rat) | Wisp1 | NP_113904.1 |
Xenopus tropicalis (tropical clawed frog) | wisp1 | XP_002939562.2 |
CCN4/WISP1 controls cutaneous wound healing by modulating proliferation, migration and ECM expression in dermal fibroblasts via ?5?1 and TNF?.
Ono M, Masaki A, Maeda A, Kilts TM, Hara ES, Komori T, Pham H, Kuboki T, Young MF
Matrix biology : journal of the International Society for Matrix Biology(2018 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
One of the most striking new findings was up-regulation of mRNA for the matricellular protein WNT1-inducible signaling pathway protein 1 (CCN4) in metastatic cells; increased protein expression was verified by immunoblotting and immunocytochemistr
Title: Differential Expression of Ccn4 and Other Genes Between Metastatic and Non-metastatic EL4 Mouse Lymphoma Cells.
Upregulation of Wnt2 expression enhanced WISP-1 and promoted vascular smooth muscle cell migration and intimal thickening.
Title: Wnt2 and WISP-1/CCN4 Induce Intimal Thickening via Promotion of Smooth Muscle Cell Migration.
CCN4 has a positive influence on chondrogenic differentiation by modulating the effects of TGF-beta3.
Title: CCN4/WISP-1 positively regulates chondrogenesis by controlling TGF-?3 function.
the Bmp3/Wisp1 signaling pathway play a key role in mesenchymal stem cell proliferation, and consequently adipogenesis.
Title: Wisp1 mediates Bmp3-stimulated mesenchymal stem cell proliferation.
WISP1 might contribute to hepatic ischemia reperfusion injury in mice and possibly depends on TLR4/TRIF signaling.
Title: WISP1 mediates hepatic warm ischemia reperfusion injury via TLR4 signaling in mice.
The following Ccn4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ccn4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu51261 | |
Clone ID Related Accession (Same CDS sequence) | XM_006520889.2 , XM_006520889.1 | |
Accession Version | XM_006520889.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 870bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | WNT1-inducible-signaling pathway protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000081.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGTGA ATGCTGTAAG ATATGTGCCC AGCAGCTTGG GGACAACTGC ACAGAGGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006520952.1 |
CDS | 453..1322 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCTGTGA ATGCTGTAAG ATATGTGCCC AGCAGCTTGG GGACAACTGC ACAGAGGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu11089 | |
Clone ID Related Accession (Same CDS sequence) | NM_018865.2 , NM_018865.3 | |
Accession Version | NM_018865.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1104bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-12-09 | |
Organism | Mus musculus(house mouse) | |
Product | WNT1-inducible-signaling pathway protein 1 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC107859.7. On Nov 17, 2006 this sequence version replaced NM_018865.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB004873.1, AK148457.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAGGTGGC TCCTGCCCTG GACGCTGGCA GCCGTGGCAG TCCTGAGGGT GGGCAACATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_061353.1 |
CDS | 174..1277 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAGGTGGC TCCTGCCCTG GACGCTGGCA GCCGTGGCAG TCCTGAGGGT GGGCAACATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu11089 | |
Clone ID Related Accession (Same CDS sequence) | NM_018865.2 , NM_018865.3 | |
Accession Version | NM_018865.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1104bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-23 | |
Organism | Mus musculus(house mouse) | |
Product | WNT1-inducible-signaling pathway protein 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC107859.7. On Jul 12, 2018 this sequence version replaced NM_018865.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB004873.1, AK013300.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAGGTGGC TCCTGCCCTG GACGCTGGCA GCCGTGGCAG TCCTGAGGGT GGGCAACATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_061353.1 |
CDS | 198..1301 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAGGTGGC TCCTGCCCTG GACGCTGGCA GCCGTGGCAG TCCTGAGGGT GGGCAACATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu51261 | |
Clone ID Related Accession (Same CDS sequence) | XM_006520889.2 , XM_006520889.1 | |
Accession Version | XM_006520889.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 870bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | WNT1-inducible-signaling pathway protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000081.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006520889.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGTGA ATGCTGTAAG ATATGTGCCC AGCAGCTTGG GGACAACTGC ACAGAGGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006520952.1 |
CDS | 232..1101 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCTGTGA ATGCTGTAAG ATATGTGCCC AGCAGCTTGG GGACAACTGC ACAGAGGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CCN4/WISP1 controls cutaneous wound healing by modulating proliferation, migration and ECM expression in dermal fibroblasts via ?5?1 and TNF?. |