Eif2b5 cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Eif2b5 |
| Entrez Gene ID | 224045 |
| Full Name | eukaryotic translation initiation factor 2B, subunit 5 epsilon |
| Synonyms | C81315 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_172265.2 | NP_758469.1 | translation initiation factor eIF-2B subunit epsilon |
| Pan troglodytes (chimpanzee) | EIF2B5 | XP_001139517.1 |
| Gallus gallus (chicken) | EIF2B5 | XP_422755.3 |
| Drosophila melanogaster (fruit fly) | eIF2B-epsilon | NP_996329.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP000082 | XP_001687758.1 |
| Arabidopsis thaliana (thale cress) | AT2G34970 | NP_181042.1 |
| EIF2B5 | XP_001104122.1 | |
| Danio rerio (zebrafish) | eif2b5 | NP_001107069.1 |
| Schizosaccharomyces pombe (fission yeast) | tif225 | NP_594285.1 |
| Arabidopsis thaliana (thale cress) | AT4G18300 | NP_193564.1 |
| Xenopus tropicalis (tropical clawed frog) | eif2b5 | XP_002935185.2 |
| Mus musculus (house mouse) | Eif2b5 | NP_758469.1 |
| Saccharomyces cerevisiae (baker's yeast) | GCD6 | NP_010497.3 |
| Eremothecium gossypii | AGOS_AGL094W | NP_986572.1 |
| Canis lupus familiaris (dog) | EIF2B5 | XP_003640192.1 |
| Bos taurus (cattle) | EIF2B5 | XP_002684924.1 |
| Rattus norvegicus (Norway rat) | Eif2b5 | NP_620221.2 |
| Kluyveromyces lactis | KLLA0A04235g | XP_451187.1 |
| Neurospora crassa | NCU02414 | XP_959596.1 |
| Homo sapiens (human) | EIF2B5 | NP_003898.2 |
| Magnaporthe oryzae (rice blast fungus) | MGG_03517 | XP_003716402.1 |
| Arabidopsis thaliana (thale cress) | AT3G02270 | NP_186876.1 |
| Oryza sativa (rice) | Os02g0812400 | NP_001048478.1 |
Related articles in PubMed
Affected astrocytes in the spinal cord of the leukodystrophy vanishing white matter.
Leferink PS, Breeuwsma N, Bugiani M, van der Knaap MS, Heine VM
Glia(2017 Dec)
Mutant eIF2B leads to impaired mitochondrial oxidative phosphorylation in vanishing white matter disease.
Raini G, Sharet R, Herrero M, Atzmon A, Shenoy A, Geiger T, Elroy-Stein O
Journal of neurochemistry141(5)694-707(2017 Jun)
Astrocytes are central in the pathomechanisms of vanishing white matter.
Dooves S, Bugiani M, Postma NL, Polder E, Land N, Horan ST, van Deijk AL, van de Kreeke A, Jacobs G, Vuong C, Klooster J, Kamermans M, Wortel J, Loos M, Wisse LE, Scheper GC, Abbink TE, Heine VM, van der Knaap MS
The Journal of clinical investigation126(4)1512-24(2016 Apr)
Eukaryotic initiation factor 2B epsilon induces cap-dependent translation and skeletal muscle hypertrophy.
Mayhew DL, Hornberger TA, Lincoln HC, Bamman MM
The Journal of physiology589(Pt 12)3023-37(2011 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These results reveal a key role of the AKT-GSK3beta-eIF2Bepsilon signaling module in regulating axon regeneration in the adult mammalian central nervous system.
Title: GSK3? regulates AKT-induced central nervous system axon regeneration via an eIF2B?-dependent, mTORC1-independent pathway.
analysis of eukaryotic initiation factor 2B epsilon phosphorylation sites and ubiquitin-modified lysine residues
Title: Identification of ubiquitin-modified lysine residues and novel phosphorylation sites on eukaryotic initiation factor 2B epsilon.
Data show that toll-like receptors (TLRs)-TRIF signalling activates eIF2B GEF through PP2A-mediated serine dephosphorylation of the eIF2B varepsilon-subunit.
Title: Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B.
mouse model of EIF2B-related leukodystrophy; findings provide evidence that hypomorphic Eif2b5 alleles lead to delayed and abnormal development and maintenance of CNS white matter
Title: A mouse model for eukaryotic translation initiation factor 2B-leucodystrophy reveals abnormal development of brain white matter.
inactivation of glycogen synthase kinase 3beta (GSK3beta) by high glucose and high insulin induces increase in synthesis of laminin beta1 via activation of eIF2Bepsilon.
Title: Glycogen synthase kinase 3beta is a novel regulator of high glucose- and high insulin-induced extracellular matrix protein synthesis in renal proximal tubular epithelial cells.
The following Eif2b5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Eif2b5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu03261 | |
| Clone ID Related Accession (Same CDS sequence) | NM_172265.2 | |
| Accession Version | NM_172265.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2154bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-27 | |
| Organism | Mus musculus(house mouse) | |
| Product | translation initiation factor eIF-2B subunit epsilon | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC161756.3 and AK160985.1. On Aug 25, 2009 this sequence version replaced NM_172265.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK145801.1, BC038620.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGCAGCCA CTGCGGCGGT GCCTGGCGCT GCGGCCGGCC GAGCGAGCAA ACGCGGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_758469.1 |
| CDS | 98..2251 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_172265.2 |
ORF Insert Sequence:
1 | ATGGCAGCCA CTGCGGCGGT GCCTGGCGCT GCGGCCGGCC GAGCGAGCAA ACGCGGCGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Affected astrocytes in the spinal cord of the leukodystrophy vanishing white matter. |
|
Mutant eIF2B leads to impaired mitochondrial oxidative phosphorylation in vanishing white matter disease. |
|
Astrocytes are central in the pathomechanisms of vanishing white matter. |
|
Eukaryotic initiation factor 2B epsilon induces cap-dependent translation and skeletal muscle hypertrophy. |