Gene Symbol | Xirp1 |
Entrez Gene ID | 22437 |
Full Name | xin actin-binding repeat containing 1 |
Synonyms | AI415219,Cmya1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Xirp1 cDNA ORF clone
gRNAs
Gene Symbol | Xirp1 |
Entrez Gene ID | 22437 |
Full Name | xin actin-binding repeat containing 1 |
Synonyms | AI415219,Cmya1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_011242958.2 | XP_011241260.1 | xin actin-binding repeat-containing protein 1 isoform X1 |
XM_030244249.1 | XP_030100109.1 | xin actin-binding repeat-containing protein 1 isoform X1 |
XM_030244248.1 | XP_030100108.1 | xin actin-binding repeat-containing protein 1 isoform X1 |
NM_011724.3 | NP_035854.3 | xin actin-binding repeat-containing protein 1 |
Sarcomeric lesions and remodeling proximal to intercalated disks in overload-induced cardiac hypertrophy.
Kebir S, Orfanos Z, Schuld J, Linhart M, Lamberz C, van der Ven PF, Schrickel J, Kirfel G, F?rst DO, Meyer R
Experimental cell research348(1)95-105(2016 Oct)
Filamin C is a highly dynamic protein associated with fast repair of myofibrillar microdamage.
Leber Y, Ruparelia AA, Kirfel G, van der Ven PF, Hoffmann B, Merkel R, Bryson-Richardson RJ, F?rst DO
Human molecular genetics25(13)2776-2788(2016 07)
Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function.
Sharma P, Abbasi C, Lazic S, Teng AC, Wang D, Dubois N, Ignatchenko V, Wong V, Liu J, Araki T, Tiburcy M, Ackerley C, Zimmermann WH, Hamilton R, Sun Y, Liu PP, Keller G, Stagljar I, Scott IC, Kislinger T, Gramolini AO
Nature communications68391(2015 Sep)
Xin-deficient mice display myopathy, impaired contractility, attenuated muscle repair and altered satellite cell functionality.
Al-Sajee D, Nissar AA, Coleman SK, Rebalka IA, Chiang A, Wathra R, van der Ven PF, Orfanos Z, Hawke TJ
Acta physiologica (Oxford, England)214(2)248-60(2015 Jun)
Aciculin interacts with filamin C and Xin and is essential for myofibril assembly, remodeling and maintenance.
Molt S, B?hrdel JB, Yakovlev S, Schein P, Orfanos Z, Kirfel G, Winter L, Wiche G, van der Ven PF, Rottbauer W, Just S, Belkin AM, F?rst DO
Journal of cell science127(Pt 16)3578-92(2014 Aug)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Xin deficiency leads to a myopathic condition characterized by increased muscle fatigability
Title: Xin-deficient mice display myopathy, impaired contractility, attenuated muscle repair and altered satellite cell functionality.
Aciculin interacts with filamin C and Xin and is essential for myofibril assembly.
Title: Aciculin interacts with filamin C and Xin and is essential for myofibril assembly, remodeling and maintenance.
mXinalpha controls the dynamics of cortical actin cytoskeleton.
Title: Intercalated disc protein, mXin?, suppresses p120-catenin-induced branching phenotype via its interactions with p120-catenin and cortactin.
The results suggest that mXinalpha play a role in myotendinous junction conductance of contractile and stretching forces.
Title: Localization and function of Xin? in mouse skeletal muscle.
Data show that mXinbeta (CMYA3/XIRP2) but not mXinalpha ((CMYA1/XIRP1) was uniquely up-regulated during the redistribution of intercellular junction from the lateral membrane of cardiomyocytes to their termini.
Title: The Xin repeat-containing protein, mXin?, initiates the maturation of the intercalated discs during postnatal heart development.
The following Xirp1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Xirp1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu19591 | |
Clone ID Related Accession (Same CDS sequence) | XM_011242958.2 , NM_011724.3 | |
Accession Version | NM_011724.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3399bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-23 | |
Organism | Mus musculus(house mouse) | |
Product | xin actin-binding repeat-containing protein 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY783852.1 and AC117245.3. On Jan 30, 2010 this sequence version replaced NM_011724.2. Sequence Note: The RefSeq transcript and protein were derived from transcript and genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF051945.2, BC117959.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849390 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCTGATG CCCAGATGCA GGTAGCTCCT ACACCAACCA TCCAAATGAG GACAGAAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_035854.3 |
CDS | 170..3568 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGGCTGATG CCCAGATGCA GGTAGCTCCT ACACCAACCA TCCAAATGAG GACAGAAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu19591 | |
Clone ID Related Accession (Same CDS sequence) | XM_011242958.2 , NM_011724.3 | |
Accession Version | XM_011242958.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3399bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | xin actin-binding repeat-containing protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011242958.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGATG CCCAGATGCA GGTAGCTCCT ACACCAACCA TCCAAATGAG GACAGAAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011241260.1 |
CDS | 164..3562 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGCTGATG CCCAGATGCA GGTAGCTCCT ACACCAACCA TCCAAATGAG GACAGAAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu90151 | |
Clone ID Related Accession (Same CDS sequence) | XM_030244249.1 , XM_030244248.1 | |
Accession Version | XM_030244249.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5442bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | xin actin-binding repeat-containing protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGATG CCCAGATGCA GGTAGCTCCT ACACCAACCA TCCAAATGAG GACAGAAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030100109.1 |
CDS | 154..5595 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCTGATG CCCAGATGCA GGTAGCTCCT ACACCAACCA TCCAAATGAG GACAGAAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu90151 | |
Clone ID Related Accession (Same CDS sequence) | XM_030244249.1 , XM_030244248.1 | |
Accession Version | XM_030244248.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5442bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | xin actin-binding repeat-containing protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000075.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTGATG CCCAGATGCA GGTAGCTCCT ACACCAACCA TCCAAATGAG GACAGAAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030100108.1 |
CDS | 165..5606 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGCTGATG CCCAGATGCA GGTAGCTCCT ACACCAACCA TCCAAATGAG GACAGAAGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Sarcomeric lesions and remodeling proximal to intercalated disks in overload-induced cardiac hypertrophy. |
Filamin C is a highly dynamic protein associated with fast repair of myofibrillar microdamage. |
Evolutionarily conserved intercalated disc protein Tmem65 regulates cardiac conduction and connexin 43 function. |
Xin-deficient mice display myopathy, impaired contractility, attenuated muscle repair and altered satellite cell functionality. |
Aciculin interacts with filamin C and Xin and is essential for myofibril assembly, remodeling and maintenance. |