Gene Symbol | Vash2 |
Entrez Gene ID | 226841 |
Full Name | vasohibin 2 |
Synonyms | B130052G07Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Vash2 cDNA ORF clone
Gene Symbol | Vash2 |
Entrez Gene ID | 226841 |
Full Name | vasohibin 2 |
Synonyms | B130052G07Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_011238913.3 | XP_011237215.1 | tubulinyl-Tyr carboxypeptidase 2 isoform X1 |
XM_011238913.2 | XP_011237215.1 | vasohibin-2 isoform X1 |
XM_006497150.4 | XP_006497213.1 | tubulinyl-Tyr carboxypeptidase 2 isoform X1 |
NM_144879.2 | NP_659128.2 | tubulinyl-Tyr carboxypeptidase 2 |
XM_006497149.3 | XP_006497212.1 | vasohibin-2 isoform X1 |
XM_006497149.4 | XP_006497212.1 | tubulinyl-Tyr carboxypeptidase 2 isoform X1 |
XM_006497150.3 | XP_006497213.1 | vasohibin-2 isoform X1 |
Rattus norvegicus (Norway rat) | Vash2 | NP_001102552.1 |
Pan troglodytes (chimpanzee) | VASH2 | XP_001170882.1 |
Gallus gallus (chicken) | VASH2 | XP_419424.4 |
Homo sapiens (human) | VASH2 | NP_079025.2 |
Mus musculus (house mouse) | Vash2 | NP_659128.2 |
Canis lupus familiaris (dog) | VASH2 | XP_005622414.1 |
Danio rerio (zebrafish) | vash2 | NP_001020694.1 |
Xenopus tropicalis (tropical clawed frog) | vash2 | XP_002934733.2 |
VASH2 | XP_001107184.1 |
Requisite role of vasohibin-2 in spontaneous gastric cancer formation and accumulation of cancer-associated fibroblasts.
Suzuki Y, Kitahara S, Suematsu T, Oshima M, Sato Y
Cancer science108(12)2342-2351(2017 Dec)
Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation.
Aillaud C, Bosc C, Peris L, Bosson A, Heemeryck P, Van Dijk J, Le Friec J, Boulan B, Vossier F, Sanman LE, Syed S, Amara N, Cout? Y, Lafanech?re L, Denarier E, Delphin C, Pelletier L, Humbert S, Bogyo M, Andrieux A, Rogowski K, Moutin MJ
Science (New York, N.Y.)358(6369)1448-1453(2017 12)
Vasohibin 2 promotes epithelial-mesenchymal transition in human breast cancer via activation of transforming growth factor ? 1 and hypoxia dependent repression of GATA-binding factor 3.
Tu M, Li Z, Liu X, Lv N, Xi C, Lu Z, Wei J, Song G, Chen J, Guo F, Jiang K, Wang S, Gao W, Miao Y
Cancer letters388187-197(2017 Mar)
Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation.
Suenaga K, Kitahara S, Suzuki Y, Kobayashi M, Horie S, Sugawara J, Yaegashi N, Sato Y
PloS one9(9)e104728(2014)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These results suggest that VASH2 plays an important role in gastric tumor progression via the accumulation of cancer-associated fibroblasts
Title: Requisite role of vasohibin-2 in spontaneous gastric cancer formation and accumulation of cancer-associated fibroblasts.
VASH2 drives breast cancer cells to undergo EMT by activation of the TGFbeta1 pathway and hypoxia dependent repression GATA3-ESR1 pathway, leading to cancer metastasis.
Title: Vasohibin 2 promotes epithelial-mesenchymal transition in human breast cancer via activation of transforming growth factor ? 1 and hypoxia dependent repression of GATA-binding factor 3.
VASH2 may modulate the onset of tumors in the gastrointestinal tract by regulating tumor angiogenesis.
Title: Vasohibin-2 modulates tumor onset in the gastrointestinal tract by normalizing tumor angiogenesis.
VASH1 and VASH2 showed distinctive localization and opposing function on the fetoplacental vascularization.
Title: Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation.
Loss of vasohibin-2 is associated with deficient angiogenesis in the termination sprouting front of endothelial cells.
Title: Distinctive localization and opposed roles of vasohibin-1 and vasohibin-2 in the regulation of angiogenesis.
The following Vash2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vash2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu13361 | |
Clone ID Related Accession (Same CDS sequence) | NM_144879.2 | |
Accession Version | NM_144879.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1068bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-19 | |
Organism | Mus musculus(house mouse) | |
Product | tubulinyl-Tyr carboxypeptidase 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB840589.1, AK140989.1 and AW488800.1. On Mar 14, 2009 this sequence version replaced NM_144879.1. Transcript Variant: This variant (1) represents the longer transcript and is protein-coding. ##Evidence-Data-START## Transcript exon combination :: AK140989.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139, SAMN01164142 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGACCGGCT CTGCCGCCGA CACTCACCGC TGCCCCCACC CCAAAATCAC CAAAGGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_659128.2 |
CDS | 425..1492 |
Translation |
Target ORF information:
Target ORF information:
|
NM_144879.2 |
1 | ATGACCGGCT CTGCCGCCGA CACTCACCGC TGCCCCCACC CCAAAATCAC CAAAGGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu28952 | |
Clone ID Related Accession (Same CDS sequence) | XM_011238913.3 , XM_011238913.2 , XM_006497150.4 , XM_006497149.3 , XM_006497149.4 , XM_006497150.3 | |
Accession Version | XM_011238913.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | vasohibin-2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011238913.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACCGGCT CTGCCGCCGA CACTCACCGC TGCCCCCACC CCAAAATCAC CAAAGGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011237215.1 |
CDS | 564..1751 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011238913.2 |
1 | ATGACCGGCT CTGCCGCCGA CACTCACCGC TGCCCCCACC CCAAAATCAC CAAAGGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu28952 | |
Clone ID Related Accession (Same CDS sequence) | XM_011238913.3 , XM_011238913.2 , XM_006497150.4 , XM_006497149.3 , XM_006497149.4 , XM_006497150.3 | |
Accession Version | XM_006497149.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | vasohibin-2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006497149.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACCGGCT CTGCCGCCGA CACTCACCGC TGCCCCCACC CCAAAATCAC CAAAGGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006497212.1 |
CDS | 306..1493 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006497149.3 |
1 | ATGACCGGCT CTGCCGCCGA CACTCACCGC TGCCCCCACC CCAAAATCAC CAAAGGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu28952 | |
Clone ID Related Accession (Same CDS sequence) | XM_011238913.3 , XM_011238913.2 , XM_006497150.4 , XM_006497149.3 , XM_006497149.4 , XM_006497150.3 | |
Accession Version | XM_006497150.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | vasohibin-2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006497150.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACCGGCT CTGCCGCCGA CACTCACCGC TGCCCCCACC CCAAAATCAC CAAAGGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006497213.1 |
CDS | 539..1726 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006497150.3 |
1 | ATGACCGGCT CTGCCGCCGA CACTCACCGC TGCCCCCACC CCAAAATCAC CAAAGGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu28952 | |
Clone ID Related Accession (Same CDS sequence) | XM_011238913.3 , XM_011238913.2 , XM_006497150.4 , XM_006497149.3 , XM_006497149.4 , XM_006497150.3 | |
Accession Version | XM_011238913.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | tubulinyl-Tyr carboxypeptidase 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_011238913.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACCGGCT CTGCCGCCGA CACTCACCGC TGCCCCCACC CCAAAATCAC CAAAGGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011237215.1 |
CDS | 562..1749 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011238913.3 |
1 | ATGACCGGCT CTGCCGCCGA CACTCACCGC TGCCCCCACC CCAAAATCAC CAAAGGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu28952 | |
Clone ID Related Accession (Same CDS sequence) | XM_011238913.3 , XM_011238913.2 , XM_006497150.4 , XM_006497149.3 , XM_006497149.4 , XM_006497150.3 | |
Accession Version | XM_006497150.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | tubulinyl-Tyr carboxypeptidase 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006497150.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACCGGCT CTGCCGCCGA CACTCACCGC TGCCCCCACC CCAAAATCAC CAAAGGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006497213.1 |
CDS | 537..1724 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006497150.4 |
1 | ATGACCGGCT CTGCCGCCGA CACTCACCGC TGCCCCCACC CCAAAATCAC CAAAGGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu28952 | |
Clone ID Related Accession (Same CDS sequence) | XM_011238913.3 , XM_011238913.2 , XM_006497150.4 , XM_006497149.3 , XM_006497149.4 , XM_006497150.3 | |
Accession Version | XM_006497149.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | tubulinyl-Tyr carboxypeptidase 2 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006497149.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACCGGCT CTGCCGCCGA CACTCACCGC TGCCCCCACC CCAAAATCAC CAAAGGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006497212.1 |
CDS | 364..1551 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006497149.4 |
1 | ATGACCGGCT CTGCCGCCGA CACTCACCGC TGCCCCCACC CCAAAATCAC CAAAGGCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Requisite role of vasohibin-2 in spontaneous gastric cancer formation and accumulation of cancer-associated fibroblasts. |
Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation. |
Vasohibin 2 promotes epithelial-mesenchymal transition in human breast cancer via activation of transforming growth factor ? 1 and hypoxia dependent repression of GATA-binding factor 3. |
Role of the vasohibin family in the regulation of fetoplacental vascularization and syncytiotrophoblast formation. |