Gene Symbol | Plcl1 |
Entrez Gene ID | 227120 |
Full Name | phospholipase C-like 1 |
Synonyms | C230017K02Rik,PLC-L,PLC-L1,PLCE,PLCL,PLDL1,PRIP,PRIP-1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Plcl1 cDNA ORF clone
Gene Symbol | Plcl1 |
Entrez Gene ID | 227120 |
Full Name | phospholipase C-like 1 |
Synonyms | C230017K02Rik,PLC-L,PLC-L1,PLCE,PLCL,PLDL1,PRIP,PRIP-1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001114663.1 | NP_001108135.1 | inactive phospholipase C-like protein 1 |
Pan troglodytes (chimpanzee) | PLCL1 | XP_001169560.1 |
PLCL1 | XP_001089483.1 | |
Canis lupus familiaris (dog) | PLCL1 | XP_536020.4 |
Rattus norvegicus (Norway rat) | Plcl1 | NP_445908.1 |
Bos taurus (cattle) | PLCL1 | NP_001178208.1 |
Xenopus tropicalis (tropical clawed frog) | plcl1 | XP_002937769.2 |
Gallus gallus (chicken) | PLCL1 | XP_421916.3 |
Mus musculus (house mouse) | Plcl1 | NP_001108135.1 |
Homo sapiens (human) | PLCL1 | NP_006217.3 |
Suppression of cell migration by phospholipase C-related catalytically inactive protein-dependent modulation of PI3K signalling.
Asano S, Taniguchi Y, Yamawaki Y, Gao J, Harada K, Takeuchi H, Hirata M, Kanematsu T
Scientific reports7(1)5408(2017 Jul)
Phospholipase C-related but catalytically inactive proteins regulate ovarian follicle development.
Matsuda M, Hirata M
The Journal of biological chemistry292(20)8369-8380(2017 05)
Phospholipase C-related, but catalytically inactive protein (PRIP) up-regulates osteoclast differentiation via calcium-calcineurin-NFATc1 signaling.
Murakami A, Matsuda M, Harada Y, Hirata M
The Journal of biological chemistry292(19)7994-8006(2017 05)
Phospholipase C-related Catalytically Inactive Protein Is a New Modulator of Thermogenesis Promoted by ?-Adrenergic Receptors in Brown Adipocytes.
Oue K, Zhang J, Harada-Hada K, Asano S, Yamawaki Y, Hayashiuchi M, Furusho H, Takata T, Irifune M, Hirata M, Kanematsu T
The Journal of biological chemistry291(8)4185-96(2016 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These results suggest that PRIPs are positively involved in the development of follicles via their regulation of LH-LHR signaling and estradiol secretion.
Title: Phospholipase C-related but catalytically inactive proteins regulate ovarian follicle development.
PRIP promotes the translocation of phosphatases to lipid droplets to trigger the dephosphorylation of HSL and perilipin A, thus reducing PKA-mediated lipolysis.
Title: Phospholipase C-related catalytically inactive protein (PRIP) regulates lipolysis in adipose tissue by modulating the phosphorylation of hormone-sensitive lipase.
Data show that PRIP is required for the fusion of Staphylococcus aureus-containing autophagosome-like vacuoles with lysosomes, indicating that PRIP is a novel modulator in the regulation of the innate immune system in non-phagocytic host cells.
Title: Phospholipase C-related catalytically inactive protein participates in the autophagic elimination of Staphylococcus aureus infecting mouse embryonic fibroblasts.
Suppressed expression of PRIP-1 induces an elevated expression of KCC2 in the spinal cord, resulting in inhibition of nociception and amelioration of neuropathic pain in DKO mice.
Title: Phospholipase C-related but catalytically inactive protein modulates pain behavior in a neuropathic pain model in mice.
PRIP is a novel LC3-binding protein that acts as a negative modulator of autophagosome formation.
Title: Phospholipase C-related catalytically inactive protein, a novel microtubule-associated protein 1 light chain 3-binding protein, negatively regulates autophagosome formation.
The following Plcl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Plcl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu13063 | |
Clone ID Related Accession (Same CDS sequence) | NM_001114663.1 | |
Accession Version | NM_001114663.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3291bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-20 | |
Organism | Mus musculus(house mouse) | |
Product | inactive phospholipase C-like protein 1 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AK083136.1, BE981359.1, AK140530.1, AI644888.1 and AC145691.5. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK140530.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCTGAGG GCGCGGCTAG CAGGGAGGCT CCGGCGCCTC TCGACGTTGC CGGGGGCGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001108135.1 |
CDS | 443..3733 |
Translation |
Target ORF information:
Target ORF information:
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NM_001114663.1 |
1 | ATGGCTGAGG GCGCGGCTAG CAGGGAGGCT CCGGCGCCTC TCGACGTTGC CGGGGGCGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Suppression of cell migration by phospholipase C-related catalytically inactive protein-dependent modulation of PI3K signalling. |
Phospholipase C-related but catalytically inactive proteins regulate ovarian follicle development. |
Phospholipase C-related, but catalytically inactive protein (PRIP) up-regulates osteoclast differentiation via calcium-calcineurin-NFATc1 signaling. |
Phospholipase C-related Catalytically Inactive Protein Is a New Modulator of Thermogenesis Promoted by ?-Adrenergic Receptors in Brown Adipocytes. |