Gene Symbol | Ndufs1 |
Entrez Gene ID | 227197 |
Full Name | NADH dehydrogenase (ubiquinone) Fe-S protein 1 |
Synonyms | 5830412M15Rik,9930026A05Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Ndufs1 cDNA ORF clone
gRNAs
Gene Symbol | Ndufs1 |
Entrez Gene ID | 227197 |
Full Name | NADH dehydrogenase (ubiquinone) Fe-S protein 1 |
Synonyms | 5830412M15Rik,9930026A05Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001160040.1 | NP_001153512.1 | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor |
NM_001160039.1 | NP_001153511.1 | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor |
XM_006495952.3 | XP_006496015.1 | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 |
NM_145518.2 | NP_663493.2 | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor |
XM_006495952.4 | XP_006496015.1 | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 |
NM_001160038.1 | NP_001153510.1 | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor |
XM_030253694.1 | XP_030109554.1 | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 |
Danio rerio (zebrafish) | ndufs1 | NP_001007766.1 |
Drosophila melanogaster (fruit fly) | ND75 | NP_511083.1 |
Arabidopsis thaliana (thale cress) | EMB1467 | NP_568550.1 |
Oryza sativa (rice) | Os03g0713400 | NP_001051072.1 |
Xenopus tropicalis (tropical clawed frog) | ndufs1 | XP_002936432.2 |
Neurospora crassa | NCU01765 | XP_957188.2 |
Homo sapiens (human) | NDUFS1 | NP_001186913.1 |
NDUFS1 | XP_001105816.2 | |
Rattus norvegicus (Norway rat) | Ndufs1 | NP_001005550.1 |
Caenorhabditis elegans (roundworm) | nuo-5 | NP_503733.1 |
Canis lupus familiaris (dog) | NDUFS1 | XP_005640630.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_03155 | XP_003716838.1 |
Pan troglodytes (chimpanzee) | NDUFS1 | NP_001073384.1 |
Bos taurus (cattle) | NDUFS1 | NP_777245.1 |
Mus musculus (house mouse) | Ndufs1 | NP_001153510.1 |
Gallus gallus (chicken) | NDUFS1 | NP_001006518.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP001653 | XP_003435895.1 |
High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Conformational change of mitochondrial complex I increases ROS sensitivity during ischemia.
Gorenkova N, Robinson E, Grieve DJ, Galkin A
Antioxidants & redox signaling19(13)1459-68(2013 Nov)
TNF?-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formation.
Huai J, V?gtle FN, J?ckel L, Li Y, Kiefer T, Ricci JE, Borner C
Journal of cell science126(Pt 17)4015-25(2013 Sep)
Region-specific expression of mitochondrial complex I genes during murine brain development.
Wirtz S, Schuelke M
PloS one6(4)e18897(2011 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The transition of mitochondrial complex I into the D-form in the absence of oxygen may represent a key event in promoting cardiac injury during I/R.
Title: Conformational change of mitochondrial complex I increases ROS sensitivity during ischemia.
lysosomal membrane permeability induced by TNFalpha plus cycloheximide, the release of lysosomal cathepsins and reactive oxygen species formation require the caspase-3-mediated cleavage of the p75 NDUFS1 subunit of respiratory complex I.
Title: TNF?-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formation.
The following Ndufs1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ndufs1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu18917 | |
Clone ID Related Accession (Same CDS sequence) | NM_001160040.1 , NM_001160039.1 , XM_006495952.3 , NM_145518.2 , XM_006495952.4 , NM_001160038.1 , XM_030253694.1 | |
Accession Version | NM_001160040.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2184bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-03 | |
Organism | Mus musculus(house mouse) | |
Product | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY709888.1, BG808119.1, AK036926.1 and AV444601.1. Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660817.100468.1, AK146814.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164139 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTTAAGGA TACCTATAAA AAGGGCCTTG ATAGGCCTTT CTAATTCTCC TAAAGGATAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001153512.1 |
CDS | 401..2584 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTTAAGGA TACCTATAAA AAGGGCCTTG ATAGGCCTTT CTAATTCTCC TAAAGGATAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu18917 | |
Clone ID Related Accession (Same CDS sequence) | NM_001160040.1 , NM_001160039.1 , XM_006495952.3 , NM_145518.2 , XM_006495952.4 , NM_001160038.1 , XM_030253694.1 | |
Accession Version | NM_001160039.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2184bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-18 | |
Organism | Mus musculus(house mouse) | |
Product | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY709888.1, CN715066.1, AK036926.1 and AV444601.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660813.249299.1, SRR6116558.42098.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164143 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTTAAGGA TACCTATAAA AAGGGCCTTG ATAGGCCTTT CTAATTCTCC TAAAGGATAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001153511.1 |
CDS | 347..2530 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTTAAGGA TACCTATAAA AAGGGCCTTG ATAGGCCTTT CTAATTCTCC TAAAGGATAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu18917 | |
Clone ID Related Accession (Same CDS sequence) | NM_001160040.1 , NM_001160039.1 , XM_006495952.3 , NM_145518.2 , XM_006495952.4 , NM_001160038.1 , XM_030253694.1 | |
Accession Version | NM_145518.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2184bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-03 | |
Organism | Mus musculus(house mouse) | |
Product | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY709888.1, AK036926.1 and AV444601.1. On May 9, 2009 this sequence version replaced NM_145518.1. Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC006660.1, AK142711.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTTAAGGA TACCTATAAA AAGGGCCTTG ATAGGCCTTT CTAATTCTCC TAAAGGATAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_663493.2 |
CDS | 243..2426 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTTAAGGA TACCTATAAA AAGGGCCTTG ATAGGCCTTT CTAATTCTCC TAAAGGATAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu18917 | |
Clone ID Related Accession (Same CDS sequence) | NM_001160040.1 , NM_001160039.1 , XM_006495952.3 , NM_145518.2 , XM_006495952.4 , NM_001160038.1 , XM_030253694.1 | |
Accession Version | NM_001160038.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2184bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Mus musculus(house mouse) | |
Product | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY709888.1, BU708393.1, AK036926.1 and AV444601.1. Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3224858.8518.1, SRR5189679.170577.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164135, SAMN01164143 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTTAAGGA TACCTATAAA AAGGGCCTTG ATAGGCCTTT CTAATTCTCC TAAAGGATAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001153510.1 |
CDS | 505..2688 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTTAAGGA TACCTATAAA AAGGGCCTTG ATAGGCCTTT CTAATTCTCC TAAAGGATAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu18917 | |
Clone ID Related Accession (Same CDS sequence) | NM_001160040.1 , NM_001160039.1 , XM_006495952.3 , NM_145518.2 , XM_006495952.4 , NM_001160038.1 , XM_030253694.1 | |
Accession Version | XM_006495952.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2184bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006495952.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTAAGGA TACCTATAAA AAGGGCCTTG ATAGGCCTTT CTAATTCTCC TAAAGGATAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006496015.1 |
CDS | 322..2505 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTTAAGGA TACCTATAAA AAGGGCCTTG ATAGGCCTTT CTAATTCTCC TAAAGGATAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu18917 | |
Clone ID Related Accession (Same CDS sequence) | NM_001160040.1 , NM_001160039.1 , XM_006495952.3 , NM_145518.2 , XM_006495952.4 , NM_001160038.1 , XM_030253694.1 | |
Accession Version | XM_006495952.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2184bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006495952.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTAAGGA TACCTATAAA AAGGGCCTTG ATAGGCCTTT CTAATTCTCC TAAAGGATAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006496015.1 |
CDS | 328..2511 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTTAAGGA TACCTATAAA AAGGGCCTTG ATAGGCCTTT CTAATTCTCC TAAAGGATAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu18917 | |
Clone ID Related Accession (Same CDS sequence) | NM_001160040.1 , NM_001160039.1 , XM_006495952.3 , NM_145518.2 , XM_006495952.4 , NM_001160038.1 , XM_030253694.1 | |
Accession Version | XM_030253694.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2184bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000067.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTAAGGA TACCTATAAA AAGGGCCTTG ATAGGCCTTT CTAATTCTCC TAAAGGATAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_030109554.1 |
CDS | 253..2436 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGTTAAGGA TACCTATAAA AAGGGCCTTG ATAGGCCTTT CTAATTCTCC TAAAGGATAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
High-throughput discovery of novel developmental phenotypes. |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Conformational change of mitochondrial complex I increases ROS sensitivity during ischemia. |
TNF?-induced lysosomal membrane permeability is downstream of MOMP and triggered by caspase-mediated NDUFS1 cleavage and ROS formation. |
Region-specific expression of mitochondrial complex I genes during murine brain development. |