Gene Symbol | Rbm15 |
Entrez Gene ID | 229700 |
Full Name | RNA binding motif protein 15 |
Synonyms | C230088J01Rik,mKIAA1438 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Rbm15 cDNA ORF clone
Gene Symbol | Rbm15 |
Entrez Gene ID | 229700 |
Full Name | RNA binding motif protein 15 |
Synonyms | C230088J01Rik,mKIAA1438 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_001045807.1 | NP_001039272.1 | RNA-binding protein 15 |
Rattus norvegicus (Norway rat) | Rbm15 | XP_003749428.1 |
Gallus gallus (chicken) | LOC100859595 | XP_003642784.1 |
Homo sapiens (human) | RBM15 | NP_073605.4 |
Pan troglodytes (chimpanzee) | RBM15 | XP_524800.2 |
Canis lupus familiaris (dog) | RBM15 | XP_537035.1 |
Mus musculus (house mouse) | Rbm15 | NP_001039272.1 |
Xenopus tropicalis (tropical clawed frog) | rbm15 | XP_002933033.1 |
Bos taurus (cattle) | RBM15 | XP_005204276.1 |
Danio rerio (zebrafish) | rbm15 | XP_001335820.1 |
RBM15 | XP_001100087.1 |
A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing.
Moindrot B, Cerase A, Coker H, Masui O, Grijzenhout A, Pintacuda G, Schermelleh L, Nesterova TB, Brockdorff N
Cell reports12(4)562-72(2015 Jul)
Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl.
Xiao N, Laha S, Das SP, Morlock K, Jesneck JL, Raffel GD
Blood125(6)941-8(2015 Feb)
Hematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress.
Xiao N, Jani K, Morgan K, Okabe R, Cullen DE, Jesneck JL, Raffel GD
Blood119(21)4898-907(2012 May)
Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation.
Lee JH, Skalnik DG
PloS one7(8)e42965(2012)
The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1.
Uranishi H, Zolotukhin AS, Lindtner S, Warming S, Zhang GM, Bear J, Copeland NG, Jenkins NA, Pavlakis GN, Felber BK
The Journal of biological chemistry284(38)26106-16(2009 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Rbm15 is required for Xist-mediated silencing. Rbm15 is important for efficient deposition of H3K27me3 on the inactive chromosome.
Title: A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing.
Rbm15 regulates the alternative splicing of Mpl-TR, a truncated isoform of c-Mpl, which modulates Thrombopoietin-mediated signaling.
Title: Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl.
A requirement for Ott1 in stress hematopoiesis suggests that Ott1-dependent processes may converge with those affected by aging.
Title: Hematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress.
both Rbm15 and the leukemogenic Rbm15-Mkl1 fusion protein interact with the Setd1b histone H3-Lys4 methyltransferase
Title: Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation.
c-Myc is a target of RNA-binding motif protein 15 in the regulation of adult hematopoietic stem cell and megakaryocyte development.
Title: c-Myc is a target of RNA-binding motif protein 15 in the regulation of adult hematopoietic stem cell and megakaryocyte development.
The following Rbm15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rbm15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu01129 | |
Clone ID Related Accession (Same CDS sequence) | NM_001045807.1 | |
Accession Version | NM_001045807.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2889bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-06-20 | |
Organism | Mus musculus(house mouse) | |
Product | RNA-binding protein 15 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC120590.1. On or before Jan 29, 2007 this sequence version replaced XM_131139.6, XM_900123.2, XM_913302.2, XM_987358.1, XM_987320.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC120590.1, AK077048.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164140, SAMN01164143 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAGGTCTG CGGGGCGGGA GCCTTTGCCG CGGCGGAGTC CAAGATGGCG GCGTGCGAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001039272.1 |
CDS | 210..3098 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001045807.1 |
1 | ATGAGGTCTG CGGGGCGGGA GCCTTTGCCG CGGCGGAGTC CAAGATGGCG GCGTGCGAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
A Pooled shRNA Screen Identifies Rbm15, Spen, and Wtap as Factors Required for Xist RNA-Mediated Silencing. |
Ott1 (Rbm15) regulates thrombopoietin response in hematopoietic stem cells through alternative splicing of c-Mpl. |
Hematopoietic stem cells lacking Ott1 display aspects associated with aging and are unable to maintain quiescence during proliferative stress. |
Rbm15-Mkl1 interacts with the Setd1b histone H3-Lys4 methyltransferase via a SPOC domain that is required for cytokine-independent proliferation. |
The RNA-binding motif protein 15B (RBM15B/OTT3) acts as cofactor of the nuclear export receptor NXF1. |