Gene Symbol | Sesn2 |
Entrez Gene ID | 230784 |
Full Name | sestrin 2 |
Synonyms | HI95,SEST2,Ses2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Sesn2 cDNA ORF clone
gRNAs
Gene Symbol | Sesn2 |
Entrez Gene ID | 230784 |
Full Name | sestrin 2 |
Synonyms | HI95,SEST2,Ses2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_144907.1 | NP_659156.1 | sestrin-2 |
SESN2 | XP_001113030.1 | |
Canis lupus familiaris (dog) | SESN2 | XP_544461.2 |
Bos taurus (cattle) | SESN2 | NP_001019678.1 |
Homo sapiens (human) | SESN2 | NP_113647.1 |
Mus musculus (house mouse) | Sesn2 | NP_659156.1 |
Pan troglodytes (chimpanzee) | SESN2 | XP_524552.3 |
Danio rerio (zebrafish) | sesn2 | NP_001073444.1 |
Rattus norvegicus (Norway rat) | Sesn2 | NP_001102828.1 |
Xenopus tropicalis (tropical clawed frog) | sesn2 | NP_001073030.1 |
Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1? pathway.
Quan N, Wang L, Chen X, Luckett C, Cates C, Rousselle T, Zheng Y, Li J
Journal of molecular and cellular cardiology(2018 Jan)
The role of physical exercise on Sestrin1 and 2 accumulations in the skeletal muscle of mice.
Crisol BM, Lenhare L, Gaspar RS, Gaspar RC, Mu?oz VR, da Silva ASR, Cintra DE, Moura LP, Pauli JR, Ropelle ER
Life sciences(2017 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Decreased Sesn2 levels in aging lead to a blunted ischemic AMPK activation, alterations in substrate metabolism, and an increased sensitivity to ischemic insults.
Title: Sestrin2 prevents age-related intolerance to ischemia and reperfusion injury by modulating substrate metabolism.
SESN2 suppressed ER stress-mediated apoptosis. SESN2 attenuated hepatic injury in mice.
Title: Activating transcription factor 6-dependent sestrin 2 induction ameliorates ER stress-mediated liver injury.
Our findings further revealed that Sesn2-induced autophagy contributed to restore the impaired insulin signaling through the activation of AMPK signal. Even in the presence of palmitate, Sesn2 up-regulation maintained insulin sensitivity and glucose metabolism via AMPK-dependent autophagic activation.
Title: Sestrin 2 induces autophagy and attenuates insulin resistance by regulating AMPK signaling in C2C12 myotubes.
Oleanolic acid can attenuate hepatic ischemia reperfusion injury via HO-1/Sesn2 signaling pathway.
Title: Oleanolic acid attenuates liver ischemia reperfusion injury by HO-1/Sesn2 signaling pathway.
p53-dependent coordination with SESN2 regulates AMPK and mTORC1 signaling and controls parturition timing
Title: p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing.
The following Sesn2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Sesn2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu21856 | |
Clone ID Related Accession (Same CDS sequence) | NM_144907.1 | |
Accession Version | NM_144907.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-26 | |
Organism | Mus musculus(house mouse) | |
Product | sestrin-2 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC005672.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC005672.1, AK170228.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGATCGTAG CGGACTCCGA GTGCCATTCC GAGATCAAGG GCTACCTGCC GTTCACCAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_659156.1 |
CDS | 304..1746 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGATCGTAG CGGACTCCGA GTGCCATTCC GAGATCAAGG GCTACCTGCC GTTCACCAGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1? pathway. |
The role of physical exercise on Sestrin1 and 2 accumulations in the skeletal muscle of mice. |