Gene Symbol | Pilra |
Entrez Gene ID | 231805 |
Full Name | paired immunoglobin-like type 2 receptor alpha |
Synonyms | AV021745,FDF03 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Pilra cDNA ORF clone
Gene Symbol | Pilra |
Entrez Gene ID | 231805 |
Full Name | paired immunoglobin-like type 2 receptor alpha |
Synonyms | AV021745,FDF03 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_153510.3 | NP_705730.1 | paired immunoglobulin-like type 2 receptor alpha precursor |
Bos taurus (cattle) | PILRA | NP_001193279.1 |
Mus musculus (house mouse) | Pilra | NP_705730.1 |
Rattus norvegicus (Norway rat) | LOC100910669 | XP_003751197.1 |
Rattus norvegicus (Norway rat) | LOC100910497 | XP_003751201.2 |
Homo sapiens (human) | PILRA | NP_038467.2 |
Pan troglodytes (chimpanzee) | PILRA | XP_001148542.1 |
Canis lupus familiaris (dog) | LOC100686271 | XP_005621119.1 |
Bos taurus (cattle) | LOC617785 | XP_002698183.1 |
Canis lupus familiaris (dog) | PILRA | XP_005621105.1 |
Posttranslational proteolytic processing of Leda-1/Pianp involves cleavage by MMPs, ADAM10/17 and gamma-secretase.
Biswas S, Adrian M, Weber J, Evdokimov K, Winkler M, G?raud C
Biochemical and biophysical research communications477(4)661-666(2016 09)
Monocyte infiltration into obese and fibrilized tissues is regulated by PILR?.
Kohyama M, Matsuoka S, Shida K, Sugihara F, Aoshi T, Kishida K, Ishii KJ, Arase H
European journal of immunology46(5)1214-23(2016 05)
Counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilr? during the LPS-mediated immune response of murine macrophages.
Biswas S, Adrian M, Evdokimov K, Schledzewski K, Weber J, Winkler M, Goerdt S, G?raud C
Biochemical and biophysical research communications464(4)1078-83(2015 Sep)
Negative regulation of DSS-induced experimental colitis by PILR?.
Kishida K, Kohyama M, Kurashima Y, Kogure Y, Wang J, Hirayasu K, Suenaga T, Kiyono H, Kunisawa J, Arase H
International immunology27(6)307-14(2015 Jun)
PILR? negatively regulates mouse inflammatory arthritis.
Sun Y, Caplazi P, Zhang J, Mazloom A, Kummerfeld S, Quinones G, Senger K, Lesch J, Peng I, Sebrell A, Luk W, Lu Y, Lin Z, Barck K, Young J, Del Rio M, Lehar S, Asghari V, Lin W, Mariathasan S, DeVoss J, Misaghi S, Balazs M, Sai T, Haley B, Hass PE, Xu M, Ouyang W, Martin F, Lee WP, Zarrin AA
Journal of immunology (Baltimore, Md. : 1950)193(2)860-70(2014 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Thus, Leda-1/Pianp is constitutively processed by proprotein convertases, sheddases including MMPs and ADAM10/17 and intramembrane protease gamma-secretase.
Title: Posttranslational proteolytic processing of Leda-1/Pianp involves cleavage by MMPs, ADAM10/17 and gamma-secretase.
Data suggest that immune inhibitory receptor, PILRalpha, plays an important role in the prevention of obesity and liver fibrosis.
Title: Monocyte infiltration into obese and fibrilized tissues is regulated by PILR?.
demonstrate that counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilralpha is part of the complex innate immune response of macrophages and its genetically determined strain-specific modulation
Title: Counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilr? during the LPS-mediated immune response of murine macrophages.
negatively regulates inflammatory colitis by reducing the neutrophil and macrophage infiltration
Title: Negative regulation of DSS-induced experimental colitis by PILR?.
Data indicate paired Ig-like type 2 receptor (PILR)alpha Pilra-/- mice develop enhanced autoimmune arthritis.
Title: PILR? negatively regulates mouse inflammatory arthritis.
The following Pilra gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Pilra cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu02136 | |
Clone ID Related Accession (Same CDS sequence) | NM_153510.3 | |
Accession Version | NM_153510.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 909bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-07-04 | |
Organism | Mus musculus(house mouse) | |
Product | paired immunoglobulin-like type 2 receptor alpha precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BB583033.1, BY171703.1, AK041670.1 and AC125063.4. On Aug 21, 2009 this sequence version replaced NM_153510.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK041670.1, AK170000.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849382, SAMN01164135 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCTTTGC TGATCTCGCT TCCTGGAGGG ACTCCAGCCA TGGCTCAGAT CCTGCTTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_705730.1 |
CDS | 160..1068 |
Translation |
Target ORF information:
Target ORF information:
|
NM_153510.3 |
1 | ATGGCTTTGC TGATCTCGCT TCCTGGAGGG ACTCCAGCCA TGGCTCAGAT CCTGCTTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Posttranslational proteolytic processing of Leda-1/Pianp involves cleavage by MMPs, ADAM10/17 and gamma-secretase. |
Monocyte infiltration into obese and fibrilized tissues is regulated by PILR?. |
Counter-regulation of the ligand-receptor pair Leda-1/Pianp and Pilr? during the LPS-mediated immune response of murine macrophages. |
Negative regulation of DSS-induced experimental colitis by PILR?. |
PILR? negatively regulates mouse inflammatory arthritis. |