Gene Symbol | Jazf1 |
Entrez Gene ID | 231986 |
Full Name | JAZF zinc finger 1 |
Synonyms | AI591476,C820002C15,Jaz1,Tip27 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Jazf1 cDNA ORF clone
gRNAs
Gene Symbol | Jazf1 |
Entrez Gene ID | 231986 |
Full Name | JAZF zinc finger 1 |
Synonyms | AI591476,C820002C15,Jaz1,Tip27 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006505943.4 | XP_006506006.1 | juxtaposed with another zinc finger protein 1 isoform X1 |
XM_011241295.2 | XP_011239597.1 | juxtaposed with another zinc finger protein 1 isoform X2 |
NM_001168277.1 | NP_001161749.1 | juxtaposed with another zinc finger protein 1 isoform 2 |
XM_006505943.3 | XP_006506006.1 | juxtaposed with another zinc finger protein 1 isoform X1 |
XM_011241295.1 | XP_011239597.1 | juxtaposed with another zinc finger protein 1 isoform X1 |
NM_173406.3 | NP_775582.2 | juxtaposed with another zinc finger protein 1 isoform 1 |
Danio rerio (zebrafish) | jazf1a | NP_001038420.1 |
JAZF1 | XP_001088719.1 | |
Mus musculus (house mouse) | Jazf1 | NP_775582.2 |
Rattus norvegicus (Norway rat) | Jazf1 | XP_001065610.1 |
Drosophila melanogaster (fruit fly) | CG12054 | NP_001247385.2 |
Xenopus tropicalis (tropical clawed frog) | jazf1 | XP_002933429.1 |
Homo sapiens (human) | JAZF1 | NP_778231.2 |
Pan troglodytes (chimpanzee) | JAZF1 | XP_001163921.1 |
Canis lupus familiaris (dog) | JAZF1 | XP_005628721.1 |
Bos taurus (cattle) | JAZF1 | NP_001193186.1 |
Gallus gallus (chicken) | JAZF1 | NP_001186547.1 |
Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System.
Memic F, Knoflach V, Morarach K, Sadler R, Laranjeira C, Hjerling-Leffler J, Sundstr?m E, Pachnis V, Marklund U
Gastroenterology(2017 Oct)
High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)
Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression.
West DB, Engelhard EK, Adkisson M, Nava AJ, Kirov JV, Cipollone A, Willis B, Rapp J, de Jong PJ, Lloyd KC
PLoS genetics12(2)e1005691(2016 Feb)
Spatiotemporal regulation of GLI target genes in the mammalian limb bud.
Lewandowski JP, Du F, Zhang S, Powell MB, Falkenstein KN, Ji H, Vokes SA
Developmental biology406(1)92-103(2015 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
aberrant JAZF1 expression contributes to the oncogenesis and type 2 diabetes pathogenesis
Title: JAZF1 promotes proliferation of C2C12 cells, but retards their myogenic differentiation through transcriptional repression of MEF2C and MRF4-Implications for the role of Jazf1 variants in oncogenesis and type 2 diabetes.
TIP27 has an important role in glucose homeostasis through the regulation of hepatic glucose metabolism and insulin sensitivity. Furthermore, this regulation requires activation of PI3-kinase.
Title: Transcription factor TIP27 regulates glucose homeostasis and insulin sensitivity in a PI3-kinase/Akt-dependent manner in mice.
JAZF1 overexpression decreased serum cholesterol levels and hepatic cholesterol synthesis by inhibiting CREB-dependent HMGCR promoter transcriptional activity.
Title: Overexpression of JAZF1 protected ApoE-deficient mice from atherosclerosis by inhibiting hepatic cholesterol synthesis via CREB-dependent mechanisms.
JAZF1 plays an important role in lipid metabolism and may thus provide a potential tool for the treatment of obesity and lipid metabolism disorders among other diseases
Title: JAZF1 regulates visfatin expression in adipocytes via PPAR? and PPAR?/? signaling.
JAZF1 was significantly upregulated during the differentiation of 3T3-L1 preadipocytes. The overexpression of JAZF1 inhibited lipid accumulation in differentiated mature 3T3-L1 adipocytes.
Title: JAZF1 can regulate the expression of lipid metabolic genes and inhibit lipid accumulation in adipocytes.
The following Jazf1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Jazf1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu37146 | |
Clone ID Related Accession (Same CDS sequence) | XM_006505943.4 , XM_006505943.3 | |
Accession Version | XM_006505943.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | juxtaposed with another zinc finger protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006505943.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAAAGAA TGATTTACAA AGTGCCTTTG GATTACACAG ACCCACGTGT TTTAGAAAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006506006.1 |
CDS | 153..803 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAAAAGAA TGATTTACAA AGTGCCTTTG GATTACACAG ACCCACGTGT TTTAGAAAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu20349 | |
Clone ID Related Accession (Same CDS sequence) | XM_011241295.2 , NM_001168277.1 , XM_011241295.1 | |
Accession Version | NM_001168277.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-14 | |
Organism | Mus musculus(house mouse) | |
Product | juxtaposed with another zinc finger protein 1 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC107317.3, AK050474.1 and AC117212.5. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC048577.1, BU938156.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGACAGATG CTGCACGCCG AGAACAGGAA TCTCTGAAGA AGAAGATTCA GCCGAAGCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001161749.1 |
CDS | 251..790 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGACAGATG CTGCACGCCG AGAACAGGAA TCTCTGAAGA AGAAGATTCA GCCGAAGCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu20362 | |
Clone ID Related Accession (Same CDS sequence) | NM_173406.3 | |
Accession Version | NM_173406.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 732bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-26 | |
Organism | Mus musculus(house mouse) | |
Product | juxtaposed with another zinc finger protein 1 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY278789.1, AK050474.1 and AC117212.5. On Nov 26, 2009 this sequence version replaced NM_173406.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660819.171709.1, AK050474.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMN00849374, SAMN00849375 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGACAGGCA TCGCCGCCGC CTCCTTCTTC TCCAACACCT GCCGCTTCGG GGGCTGCGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_775582.2 |
CDS | 58..789 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGACAGGCA TCGCCGCCGC CTCCTTCTTC TCCAACACCT GCCGCTTCGG GGGCTGCGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu20349 | |
Clone ID Related Accession (Same CDS sequence) | XM_011241295.2 , NM_001168277.1 , XM_011241295.1 | |
Accession Version | XM_011241295.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | juxtaposed with another zinc finger protein 1 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_011241295.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACAGATG CTGCACGCCG AGAACAGGAA TCTCTGAAGA AGAAGATTCA GCCGAAGCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011239597.1 |
CDS | 156..695 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGACAGATG CTGCACGCCG AGAACAGGAA TCTCTGAAGA AGAAGATTCA GCCGAAGCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu20349 | |
Clone ID Related Accession (Same CDS sequence) | XM_011241295.2 , NM_001168277.1 , XM_011241295.1 | |
Accession Version | XM_011241295.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 540bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-02-08 | |
Organism | Mus musculus(House mouse) | |
Product | juxtaposed with another zinc finger protein 1 isoform X1 | |
Comment |
1 | ATGACAGATG CTGCACGCCG AGAACAGGAA TCTCTGAAGA AGAAGATTCA GCCGAAGCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011239597.1 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGACAGATG CTGCACGCCG AGAACAGGAA TCTCTGAAGA AGAAGATTCA GCCGAAGCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu37146 | |
Clone ID Related Accession (Same CDS sequence) | XM_006505943.4 , XM_006505943.3 | |
Accession Version | XM_006505943.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | juxtaposed with another zinc finger protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000072.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006505943.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAAAAGAA TGATTTACAA AGTGCCTTTG GATTACACAG ACCCACGTGT TTTAGAAAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006506006.1 |
CDS | 230..880 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAAAAGAA TGATTTACAA AGTGCCTTTG GATTACACAG ACCCACGTGT TTTAGAAAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. |
High-throughput discovery of novel developmental phenotypes. |
Transcriptome Analysis of Targeted Mouse Mutations Reveals the Topography of Local Changes in Gene Expression. |
Spatiotemporal regulation of GLI target genes in the mammalian limb bud. |