Gene Symbol | Mat2a |
Entrez Gene ID | 232087 |
Full Name | methionine adenosyltransferase II, alpha |
Synonyms | D630045P18Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Mat2a cDNA ORF clone
Gene Symbol | Mat2a |
Entrez Gene ID | 232087 |
Full Name | methionine adenosyltransferase II, alpha |
Synonyms | D630045P18Rik |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_145569.4 | NP_663544.1 | S-adenosylmethionine synthase isoform type-2 |
NM_001363799.1 | NP_001350728.1 | S-adenosylmethionine synthase isoform type-2 isoform 3 |
NM_145569.5 | NP_663544.1 | S-adenosylmethionine synthase isoform type-2 isoform 1 |
NM_001363798.1 | NP_001350727.1 | S-adenosylmethionine synthase isoform type-2 isoform 2 |
Bos taurus (cattle) | MAT2A | NP_001094601.1 |
Rattus norvegicus (Norway rat) | Mat2a | NP_599178.1 |
Caenorhabditis elegans (roundworm) | sams-3 | NP_500872.1 |
Schizosaccharomyces pombe (fission yeast) | sam1 | NP_596731.1 |
Caenorhabditis elegans (roundworm) | sams-5 | NP_741415.1 |
Caenorhabditis elegans (roundworm) | sams-4 | NP_500871.1 |
Caenorhabditis elegans (roundworm) | sams-1 | NP_510002.1 |
Saccharomyces cerevisiae (baker's yeast) | SAM2 | NP_010790.3 |
Homo sapiens (human) | MAT2A | NP_005902.1 |
Drosophila melanogaster (fruit fly) | Sam-S | NP_524923.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP009447 | XP_307863.1 |
Saccharomyces cerevisiae (baker's yeast) | SAM1 | NP_013281.1 |
Neurospora crassa | NCU02657 | XP_965430.1 |
Pan troglodytes (chimpanzee) | MAT2A | XP_001167501.1 |
Canis lupus familiaris (dog) | MAT2A | XP_532980.2 |
Danio rerio (zebrafish) | mat2ab | NP_001014318.1 |
Mus musculus (house mouse) | Mat2a | NP_663544.1 |
Kluyveromyces lactis | KLLA0C01782g | XP_452275.1 |
Eremothecium gossypii | AGOS_AFR692C | NP_986240.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_00383 | XP_003718693.1 |
Arabidopsis thaliana (thale cress) | MAT3 | NP_001118458.1 |
Xenopus tropicalis (tropical clawed frog) | mat2a | NP_989395.1 |
Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development.
Tang S, Fang Y, Huang G, Xu X, Padilla-Banks E, Fan W, Xu Q, Sanderson SM, Foley JF, Dowdy S, McBurney MW, Fargo DC, Williams CJ, Locasale JW, Guan Z, Li X
The EMBO journal36(21)3175-3193(2017 11)
High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
SIRT1 knock-out embryos display reduced Mat2a expression and histone methylation and are sensitive to maternal methionine restriction-induced lethality, whereas maternal methionine supplementation increases the survival of SIRT1 knock-out newborn mice.
Title: Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development.
P300 acetylates MAT IIalpha at lysine residue 81 and destabilizes MAT IIalpha by promoting its ubiquitylation and subsequent proteasomal degradation.
Title: Acetylation of MAT II? represses tumour cell growth and is decreased in human hepatocellular cancer.
MATIIalpha represses the expression of cyclooxygenase 2 (COX-2), encoded by Ptgs2, by specifically interacting with histone H3K9 methyltransferase SETDB1.
Title: Methionine adenosyltransferase II-dependent histone H3K9 methylation at the COX-2 gene locus.
Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein
Title: Methionine adenosyltransferase II serves as a transcriptional corepressor of Maf oncoprotein.
MAT2A and MAT2beta genes are induced during hepatic stellate cell activation
Title: Changes in the expression of methionine adenosyltransferase genes and S-adenosylmethionine homeostasis during hepatic stellate cell activation.
The following Mat2a gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Mat2a cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu21855 | |
Clone ID Related Accession (Same CDS sequence) | NM_145569.4 , NM_145569.5 | |
Accession Version | NM_145569.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-12-27 | |
Organism | Mus musculus(house mouse) | |
Product | S-adenosylmethionine synthase isoform type-2 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC116115.11. On May 1, 2007 this sequence version replaced NM_145569.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK034757.1, AK052764.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAACGGGC AGCTCAACGG CTTCCACGAG GCGTTCATTG AGGAGGGGAC GTTCCTCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_663544.1 |
CDS | 123..1310 |
Translation |
Target ORF information:
Target ORF information:
|
NM_145569.4 |
1 | ATGAACGGGC AGCTCAACGG CTTCCACGAG GCGTTCATTG AGGAGGGGAC GTTCCTCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu21855 | |
Clone ID Related Accession (Same CDS sequence) | NM_145569.4 , NM_145569.5 | |
Accession Version | NM_145569.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-30 | |
Organism | Mus musculus(house mouse) | |
Product | S-adenosylmethionine synthase isoform type-2 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC116115.11. On Jun 3, 2018 this sequence version replaced NM_145569.4. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK034757.1, AK144189.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAACGGGC AGCTCAACGG CTTCCACGAG GCGTTCATTG AGGAGGGGAC GTTCCTCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_663544.1 |
CDS | 121..1308 |
Translation |
Target ORF information:
Target ORF information:
|
NM_145569.5 |
1 | ATGAACGGGC AGCTCAACGG CTTCCACGAG GCGTTCATTG AGGAGGGGAC GTTCCTCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu73589 | |
Clone ID Related Accession (Same CDS sequence) | NM_001363799.1 | |
Accession Version | NM_001363799.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1098bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-30 | |
Organism | Mus musculus(house mouse) | |
Product | S-adenosylmethionine synthase isoform type-2 isoform 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK133960.1 and BC058360.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK133960.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01164131, SAMN01164133 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAACGGGC AGCTCAACGG CTTCCACGAG GCGTTCATTG AGGAGGGGAC GTTCCTCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001350728.1 |
CDS | 121..1218 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001363799.1 |
1 | ATGAACGGGC AGCTCAACGG CTTCCACGAG GCGTTCATTG AGGAGGGGAC GTTCCTCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu84334 | |
Clone ID Related Accession (Same CDS sequence) | NM_001363798.1 | |
Accession Version | NM_001363798.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1089bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-30 | |
Organism | Mus musculus(house mouse) | |
Product | S-adenosylmethionine synthase isoform type-2 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK160869.1 and BC058360.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC058360.1, AK160869.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849380, SAMN00849381 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAACGGGC AGCTCAACGG CTTCCACGAG GCGTTCATTG AGGAGGGGAC GTTCCTCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001350727.1 |
CDS | 121..1209 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001363798.1 |
1 | ATGAACGGGC AGCTCAACGG CTTCCACGAG GCGTTCATTG AGGAGGGGAC GTTCCTCTTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development. |
High-throughput discovery of novel developmental phenotypes. |