Tat cDNA ORF clone, Mus musculus(house mouse)
| Gene Symbol | Tat |
| Entrez Gene ID | 234724 |
| Full Name | tyrosine aminotransferase |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Mus musculus(house mouse) |
| Genome | |
| Summary | This gene encodes a liver-specific mitochondrial enzyme that catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Regulated by glucocorticoid and polypeptide hormones, this gene's expression is affected by deletion of a regulatory region near the albino locus on chromosome 7. Mutations in this gene cause tyrosinemia type II in humans. [provided by RefSeq, Mar 2010]. |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_146214.3 | NP_666326.1 | tyrosine aminotransferase |
| XM_030243506.1 | XP_030099366.1 | tyrosine aminotransferase isoform X1 |
| Pan troglodytes (chimpanzee) | TAT | XP_511091.2 |
| TAT | XP_001106194.1 | |
| Canis lupus familiaris (dog) | TAT | XP_536796.2 |
| Gallus gallus (chicken) | TAT | XP_004944414.1 |
| Oryza sativa (rice) | Os11g0552000 | NP_001068082.2 |
| Homo sapiens (human) | TAT | NP_000344.1 |
| Arabidopsis thaliana (thale cress) | AT5G36160 | NP_198465.3 |
| Mus musculus (house mouse) | Tat | NP_666326.1 |
| Oryza sativa (rice) | Os02g0302400 | NP_001046626.1 |
| Oryza sativa (rice) | Os06g0345200 | NP_001057579.1 |
| Bos taurus (cattle) | TAT | NP_001029762.1 |
| Rattus norvegicus (Norway rat) | Tat | NP_036800.1 |
| Danio rerio (zebrafish) | tat | NP_001071022.1 |
| Drosophila melanogaster (fruit fly) | CG1461 | NP_572953.1 |
| Anopheles gambiae (African malaria mosquito) | AgaP_AGAP000327 | XP_310789.4 |
| Caenorhabditis elegans (roundworm) | tatn-1 | NP_510454.1 |
| Oryza sativa (rice) | Os02g0302700 | NP_001046628.1 |
| Xenopus tropicalis (tropical clawed frog) | tat | NP_001006790.1 |
Related articles in PubMed
Liver maturation deficiency in p57(Kip2)-/- mice occurs in a hepatocytic p57(Kip2) expression-independent manner.
Yanagida A, Chikada H, Ito K, Umino A, Kato-Itoh M, Yamazaki Y, Sato H, Kobayashi T, Yamaguchi T, Nakayama KI, Nakauchi H, Kamiya A
Developmental biology407(2)331-43(2015 Nov)
The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation.
Labialle S, Marty V, Bortolin-Cavaill? ML, Hoareau-Osman M, Prad?re JP, Valet P, Martin PG, Cavaill? J
The EMBO journal33(19)2216-30(2014 Oct)
Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells in mice.
Kiyohashi K, Kakinuma S, Kamiya A, Sakamoto N, Nitta S, Yamanaka H, Yoshino K, Fujiki J, Murakawa M, Kusano-Kitazume A, Shimizu H, Okamoto R, Azuma S, Nakagawa M, Asahina Y, Tanimizu N, Kikuchi A, Nakauchi H, Watanabe M
Hepatology (Baltimore, Md.)57(6)2502-13(2013 Jun)
Transduced Tat-DJ-1 protein protects against oxidative stress-induced SH-SY5Y cell death and Parkinson disease in a mouse model.
Jeong HJ, Kim DW, Woo SJ, Kim HR, Kim SM, Jo HS, Park M, Kim DS, Kwon OS, Hwang IK, Han KH, Park J, Eum WS, Choi SY
Molecules and cells33(5)471-8(2012 May)
Disruption of ?-arrestins blocks glucocorticoid receptor and severely retards lung and liver development in mice.
Zhang M, Teng H, Shi J, Zhang Y
Mechanisms of development128(7-10)368-75(2011 Sep-Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Tat-DJ-1 protein protects against dopaminergic neuronal cell death in 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine (MPTP)-induced PD mouse models.
Title: Transduced Tat-DJ-1 protein protects against oxidative stress-induced SH-SY5Y cell death and Parkinson disease in a mouse model.
Through macromolecular crystallography the mTAT crystal structure was revealed at 2.9 A resolution; it showed the interaction between the pyridoxal-5'-phosphate cofactor and the enzyme, as well as the formation of a disulphide bond.
Title: Tyrosine aminotransferase: biochemical and structural properties and molecular dynamics simulations.
The following Tat gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tat cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OMu16142 | |
| Clone ID Related Accession (Same CDS sequence) | NM_146214.3 , XM_030243506.1 | |
| Accession Version | NM_146214.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1365bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-27 | |
| Organism | Mus musculus(house mouse) | |
| Product | tyrosine aminotransferase | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC124409.5. On Mar 23, 2010 this sequence version replaced NM_146214.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK149383.1, BC030728.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849380 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGACTCCT ACGTAATCCA GACGAATGTC AATGACAGCC TACCTTCAGT GCTGGATGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_666326.1 |
| CDS | 98..1462 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_146214.3 |
ORF Insert Sequence:
1 | ATGGACTCCT ACGTAATCCA GACGAATGTC AATGACAGCC TACCTTCAGT GCTGGATGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OMu16142 | |
| Clone ID Related Accession (Same CDS sequence) | NM_146214.3 , XM_030243506.1 | |
| Accession Version | XM_030243506.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1365bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-07 | |
| Organism | Mus musculus(house mouse) | |
| Product | tyrosine aminotransferase isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000074.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGACTCCT ACGTAATCCA GACGAATGTC AATGACAGCC TACCTTCAGT GCTGGATGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_030099366.1 |
| CDS | 937..2301 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_030243506.1 |
ORF Insert Sequence:
1 | ATGGACTCCT ACGTAATCCA GACGAATGTC AATGACAGCC TACCTTCAGT GCTGGATGTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Liver maturation deficiency in p57(Kip2)-/- mice occurs in a hepatocytic p57(Kip2) expression-independent manner. |
|
The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. |
|
Wnt5a signaling mediates biliary differentiation of fetal hepatic stem/progenitor cells in mice. |
|
Transduced Tat-DJ-1 protein protects against oxidative stress-induced SH-SY5Y cell death and Parkinson disease in a mouse model. |
|
Disruption of ?-arrestins blocks glucocorticoid receptor and severely retards lung and liver development in mice. |