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Tbpl1 cDNA ORF clone, Mus musculus(house mouse)

Summary

Gene Symbol Tbpl1
Entrez Gene ID 237336
Full Name TATA box binding protein-like 1
Synonyms 4732475G08,AW011832,AW491032,D18347,STD,TLF,TRF2,TRP,Tlp
General protein information
Preferred Names

TATA box binding protein-like 1

Names

TATA box-binding protein-like protein 1
21 kDa TBP-like protein
TATA box binding protein-like protein
TATA box-binding protein-related factor 2
TBP-like factor
TBP-like protein 1
TBP-related factor 2
TBP-related protein
Gene Type protein-coding
Organism Mus musculus(house mouse)
Genome

10

10|10 A3

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_006512730.4 XP_006512793.1 TATA box-binding protein-like protein 1 isoform X1
NM_011603.5 NP_035733.1 TATA box-binding protein-like protein 1
XM_006512730.3 XP_006512793.1 TATA box-binding protein-like protein 1 isoform X1

Pathways from BioSystems


Homologies


Pan troglodytes (chimpanzee) TBPL1 NP_001092762.1
Bos taurus (cattle) TBPL1 NP_001069758.1
Mus musculus (house mouse) Tbpl1 NP_035733.1
Homo sapiens (human) TBPL1 NP_001240605.1
Gallus gallus (chicken) TBPL1 NP_990086.1
Danio rerio (zebrafish) tbpl1 NP_991285.1
Canis lupus familiaris (dog) TBPL1 NP_001239188.1
Rattus norvegicus (Norway rat) Tbpl1 NP_001120673.1
Anopheles gambiae (African malaria mosquito) AgaP_AGAP007517 XP_308361.4
Caenorhabditis elegans (roundworm) tlf-1 NP_492356.1
Xenopus tropicalis (tropical clawed frog) tbpl1 NP_001004932.1

Gene Ontology


Bibliography

Related articles in PubMed

Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation.
Menendez-Montes I, Escobar B, Palacios B, G?mez MJ, Izquierdo-Garcia JL, Flores L, Jim?nez-Borreguero LJ, Aragones J, Ruiz-Cabello J, Torres M, Martin-Puig S
Developmental cell39(6)724-739(2016 12)

TBP-like protein (TLP) represses myogenesis via inhibition of the?myogenin promoter.
Nakazato A, Maeda R, Ishikawa K, Suzuki H, Tamura TA
Biochemical and biophysical research communications479(4)814-819(2016 Oct)

TRF2 is recruited to the pre-initiation complex as a testis-specific subunit of TFIIA/ALF to promote haploid cell gene expression.
Martianov I, Velt A, Davidson G, Choukrallah MA, Davidson I
Scientific reports632069(2016 Aug)

TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice.
Yabuta Y, Ohta H, Abe T, Kurimoto K, Chuma S, Saitou M
The Journal of cell biology192(5)781-95(2011 Mar)

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P
Developmental cell18(4)675-85(2010 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Overexpression and knockdown of TLP revealed that the levels of muscle-specific myosin heavy chain and the myogenic transcription factor myogenin are downregulated by TLP. The proximal AT-rich sequence of the myogenin promoter is responsible for TLP-mediated transcriptional repression.
Title: TBP-like protein (TLP) represses myogenesis via inhibition of the?myogenin promoter.

Transplantation of TRF2 overexpressing bone marrow cells into the hematopoietic system of mice resulted in the the development of T-cell lymphomas, but overexpression of the TRF2 transgene was not detectable anymore in the tumors.
Title: Moderate expression of TRF2 in the hematopoietic system increases development of large cell blastic T-cell lymphomas.

Data report on the nucleosomal organization of telomeres that have become deprotected through the deletion of the shelterin components TRF2 or POT1a/b, and show no evidence of changes or nucleosome eviction near the telomere terminus.
Title: No overt nucleosome eviction at deprotected telomeres.

these results demonstrate that TRF2 increased expression is a potent oncogenic event that along with telomerase deficiency accelerates carcinogenesis, coincidental with a derepression of telomere recombination
Title: Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis.

reconfirmed cytoplasmic localization of TRF2; genotoxins caused it to migrate to the nucleus; TRF2 may be involved in genotoxin-induced transcriptional regulation
Title: TATA-binding protein-related factor 2 is localized in the cytoplasm of mammalian cells and much of it migrates to the nucleus in response to genotoxic agents.

The following Tbpl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tbpl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OMu08452 NM_011603.5
Latest version!		 Mus musculus TATA box binding protein-like 1 (Tbpl1), mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $69.30
$99.00
OMu08452 XM_006512730.4
Latest version!		 Mus musculus TATA box binding protein-like 1 (Tbpl1), transcript variant X3, mRNA. pcDNA3.1-C-(k)DYK or customized vector 9-11 $69.30
$99.00
View Old Accession Versions >>
OMu08452 XM_006512730.3 Mus musculus TATA box binding protein-like 1 (Tbpl1), transcript variant X3, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $69.30
$99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OMu08452
Clone ID Related Accession (Same CDS sequence) XM_006512730.4 , NM_011603.5 , XM_006512730.3
Accession Version NM_011603.5 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 561bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-09-22
Organism Mus musculus(house mouse)
Product TATA box-binding protein-like protein 1
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY275848.1, AK049975.1, BE650743.1 and BE995552.1. On Apr 8, 2009 this sequence version replaced NM_011603.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK078547.1, SRR1660819.166027.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTTTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GCCATTTGAA CTTAAGGAAG ATTGCTTTGG AGGGAGCAAA TGTAATTTAT 
AAGCGTGATG TTGGGAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGTT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTCATCTT CACAGATTTT 
AAGGTGGTGA ATGTTTTGGC AGTGTGTAAC ATGCCCTTTG AGATCCGTTT GCCAGAATTT 
ACAAAGAACA ATAGACCTCA TGCCAGCTAT GAACCTGAAC TTCATCCTGC CGTGTGCTAT 
CGGATAAAGT CTCTAAGAGC TACATTACAG ATATTTTCAA CAGGAAGCAT CACAGTGACA 
GGGCCCAATG TAAAGGCTGT GGCGACTGCC GTGGAACAGA TCTACCCGTT CGTGTTTGAA 
AGCAGGAAGG AGATTTTATA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_035733.1
CDS376..936
Translation

Target ORF information:

RefSeq Version NM_011603.5
Organism Mus musculus(house mouse)
Definition Mus musculus TATA box binding protein-like 1 (Tbpl1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_011603.5

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTTTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GCCATTTGAA CTTAAGGAAG ATTGCTTTGG AGGGAGCAAA TGTAATTTAT 
AAGCGTGATG TTGGGAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGTT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTCATCTT CACAGATTTT 
AAGGTGGTGA ATGTTTTGGC AGTGTGTAAC ATGCCCTTTG AGATCCGTTT GCCAGAATTT 
ACAAAGAACA ATAGACCTCA TGCCAGCTAT GAACCTGAAC TTCATCCTGC CGTGTGCTAT 
CGGATAAAGT CTCTAAGAGC TACATTACAG ATATTTTCAA CAGGAAGCAT CACAGTGACA 
GGGCCCAATG TAAAGGCTGT GGCGACTGCC GTGGAACAGA TCTACCCGTT CGTGTTTGAA 
AGCAGGAAGG AGATTTTATA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu08452
Clone ID Related Accession (Same CDS sequence) XM_006512730.4 , NM_011603.5 , XM_006512730.3
Accession Version XM_006512730.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 561bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-21
Organism Mus musculus(house mouse)
Product TATA box-binding protein-like protein 1 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006512730.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTTTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GCCATTTGAA CTTAAGGAAG ATTGCTTTGG AGGGAGCAAA TGTAATTTAT 
AAGCGTGATG TTGGGAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGTT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTCATCTT CACAGATTTT 
AAGGTGGTGA ATGTTTTGGC AGTGTGTAAC ATGCCCTTTG AGATCCGTTT GCCAGAATTT 
ACAAAGAACA ATAGACCTCA TGCCAGCTAT GAACCTGAAC TTCATCCTGC CGTGTGCTAT 
CGGATAAAGT CTCTAAGAGC TACATTACAG ATATTTTCAA CAGGAAGCAT CACAGTGACA 
GGGCCCAATG TAAAGGCTGT GGCGACTGCC GTGGAACAGA TCTACCCGTT CGTGTTTGAA 
AGCAGGAAGG AGATTTTATA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006512793.1
CDS506..1066
Translation

Target ORF information:

RefSeq Version XM_006512730.3
Organism Mus musculus(house mouse)
Definition Mus musculus TATA box binding protein-like 1 (Tbpl1), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_006512730.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTTTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GCCATTTGAA CTTAAGGAAG ATTGCTTTGG AGGGAGCAAA TGTAATTTAT 
AAGCGTGATG TTGGGAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGTT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTCATCTT CACAGATTTT 
AAGGTGGTGA ATGTTTTGGC AGTGTGTAAC ATGCCCTTTG AGATCCGTTT GCCAGAATTT 
ACAAAGAACA ATAGACCTCA TGCCAGCTAT GAACCTGAAC TTCATCCTGC CGTGTGCTAT 
CGGATAAAGT CTCTAAGAGC TACATTACAG ATATTTTCAA CAGGAAGCAT CACAGTGACA 
GGGCCCAATG TAAAGGCTGT GGCGACTGCC GTGGAACAGA TCTACCCGTT CGTGTTTGAA 
AGCAGGAAGG AGATTTTATA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OMu08452
Clone ID Related Accession (Same CDS sequence) XM_006512730.4 , NM_011603.5 , XM_006512730.3
Accession Version XM_006512730.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 561bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-08-07
Organism Mus musculus(house mouse)
Product TATA box-binding protein-like protein 1 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006512730.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTTTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GCCATTTGAA CTTAAGGAAG ATTGCTTTGG AGGGAGCAAA TGTAATTTAT 
AAGCGTGATG TTGGGAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGTT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTCATCTT CACAGATTTT 
AAGGTGGTGA ATGTTTTGGC AGTGTGTAAC ATGCCCTTTG AGATCCGTTT GCCAGAATTT 
ACAAAGAACA ATAGACCTCA TGCCAGCTAT GAACCTGAAC TTCATCCTGC CGTGTGCTAT 
CGGATAAAGT CTCTAAGAGC TACATTACAG ATATTTTCAA CAGGAAGCAT CACAGTGACA 
GGGCCCAATG TAAAGGCTGT GGCGACTGCC GTGGAACAGA TCTACCCGTT CGTGTTTGAA 
AGCAGGAAGG AGATTTTATA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_006512793.1
CDS928..1488
Translation

Target ORF information:

RefSeq Version XM_006512730.4
Organism Mus musculus(house mouse)
Definition Mus musculus TATA box binding protein-like 1 (Tbpl1), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_006512730.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTTTAATTA CAAATGTAGT CTGTGTTTTT 
AGAACAAGAT GCCATTTGAA CTTAAGGAAG ATTGCTTTGG AGGGAGCAAA TGTAATTTAT 
AAGCGTGATG TTGGGAAAGT ATTAATGAAG CTTAGAAAAC CTAGAATTAC AGCTACAATT 
TGGTCCTCAG GAAAAATTAT TTGCACTGGA GCAACAAGTG AAGAAGAAGC TAAATTTGGT 
GCCAGACGTT TAGCCCGTAG TCTGCAGAAA CTAGGTTTTC AGGTCATCTT CACAGATTTT 
AAGGTGGTGA ATGTTTTGGC AGTGTGTAAC ATGCCCTTTG AGATCCGTTT GCCAGAATTT 
ACAAAGAACA ATAGACCTCA TGCCAGCTAT GAACCTGAAC TTCATCCTGC CGTGTGCTAT 
CGGATAAAGT CTCTAAGAGC TACATTACAG ATATTTTCAA CAGGAAGCAT CACAGTGACA 
GGGCCCAATG TAAAGGCTGT GGCGACTGCC GTGGAACAGA TCTACCCGTT CGTGTTTGAA 
AGCAGGAAGG AGATTTTATA A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation.
Developmental cell39(6)724-739(2016 12)
Menendez-Montes I,Escobar B,Palacios B,G?mez MJ,Izquierdo-Garcia JL,Flores L,Jim?nez-Borreguero LJ,Aragones J,Ruiz-Cabello J,Torres M,Martin-Puig S


book

TBP-like protein (TLP) represses myogenesis via inhibition of the?myogenin promoter.
Biochemical and biophysical research communications479(4)814-819(2016 Oct)
Nakazato A,Maeda R,Ishikawa K,Suzuki H,Tamura TA


book

TRF2 is recruited to the pre-initiation complex as a testis-specific subunit of TFIIA/ALF to promote haploid cell gene expression.
Scientific reports632069(2016 Aug)
Martianov I,Velt A,Davidson G,Choukrallah MA,Davidson I


book

TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice.
The Journal of cell biology192(5)781-95(2011 Mar)
Yabuta Y,Ohta H,Abe T,Kurimoto K,Chuma S,Saitou M


book

Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Developmental cell18(4)675-85(2010 Apr)
Guo G,Huss M,Tong GQ,Wang C,Li Sun L,Clarke ND,Robson P


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