Tbpl1 cDNA ORF clone, Mus musculus(house mouse)
Gene Symbol | Tbpl1 |
Entrez Gene ID | 237336 |
Full Name | TATA box binding protein-like 1 |
Synonyms | 4732475G08,AW011832,AW491032,D18347,STD,TLF,TRF2,TRP,Tlp |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
XM_006512730.4 | XP_006512793.1 | TATA box-binding protein-like protein 1 isoform X1 |
NM_011603.5 | NP_035733.1 | TATA box-binding protein-like protein 1 |
XM_006512730.3 | XP_006512793.1 | TATA box-binding protein-like protein 1 isoform X1 |

Pan troglodytes (chimpanzee) | TBPL1 | NP_001092762.1 |
Bos taurus (cattle) | TBPL1 | NP_001069758.1 |
Mus musculus (house mouse) | Tbpl1 | NP_035733.1 |
Homo sapiens (human) | TBPL1 | NP_001240605.1 |
Gallus gallus (chicken) | TBPL1 | NP_990086.1 |
Danio rerio (zebrafish) | tbpl1 | NP_991285.1 |
Canis lupus familiaris (dog) | TBPL1 | NP_001239188.1 |
Rattus norvegicus (Norway rat) | Tbpl1 | NP_001120673.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP007517 | XP_308361.4 |
Caenorhabditis elegans (roundworm) | tlf-1 | NP_492356.1 |
Xenopus tropicalis (tropical clawed frog) | tbpl1 | NP_001004932.1 |

Related articles in PubMed
Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation.
Menendez-Montes I, Escobar B, Palacios B, G?mez MJ, Izquierdo-Garcia JL, Flores L, Jim?nez-Borreguero LJ, Aragones J, Ruiz-Cabello J, Torres M, Martin-Puig S
Developmental cell39(6)724-739(2016 12)
TBP-like protein (TLP) represses myogenesis via inhibition of the?myogenin promoter.
Nakazato A, Maeda R, Ishikawa K, Suzuki H, Tamura TA
Biochemical and biophysical research communications479(4)814-819(2016 Oct)
TRF2 is recruited to the pre-initiation complex as a testis-specific subunit of TFIIA/ALF to promote haploid cell gene expression.
Martianov I, Velt A, Davidson G, Choukrallah MA, Davidson I
Scientific reports632069(2016 Aug)
TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice.
Yabuta Y, Ohta H, Abe T, Kurimoto K, Chuma S, Saitou M
The Journal of cell biology192(5)781-95(2011 Mar)
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst.
Guo G, Huss M, Tong GQ, Wang C, Li Sun L, Clarke ND, Robson P
Developmental cell18(4)675-85(2010 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Overexpression and knockdown of TLP revealed that the levels of muscle-specific myosin heavy chain and the myogenic transcription factor myogenin are downregulated by TLP. The proximal AT-rich sequence of the myogenin promoter is responsible for TLP-mediated transcriptional repression.
Title: TBP-like protein (TLP) represses myogenesis via inhibition of the?myogenin promoter.
Transplantation of TRF2 overexpressing bone marrow cells into the hematopoietic system of mice resulted in the the development of T-cell lymphomas, but overexpression of the TRF2 transgene was not detectable anymore in the tumors.
Title: Moderate expression of TRF2 in the hematopoietic system increases development of large cell blastic T-cell lymphomas.
Data report on the nucleosomal organization of telomeres that have become deprotected through the deletion of the shelterin components TRF2 or POT1a/b, and show no evidence of changes or nucleosome eviction near the telomere terminus.
Title: No overt nucleosome eviction at deprotected telomeres.
these results demonstrate that TRF2 increased expression is a potent oncogenic event that along with telomerase deficiency accelerates carcinogenesis, coincidental with a derepression of telomere recombination
Title: Telomerase abrogation dramatically accelerates TRF2-induced epithelial carcinogenesis.
reconfirmed cytoplasmic localization of TRF2; genotoxins caused it to migrate to the nucleus; TRF2 may be involved in genotoxin-induced transcriptional regulation
Title: TATA-binding protein-related factor 2 is localized in the cytoplasm of mammalian cells and much of it migrates to the nucleus in response to genotoxic agents.
The following Tbpl1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Tbpl1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu08452 | |
Clone ID Related Accession (Same CDS sequence) | XM_006512730.4 , NM_011603.5 , XM_006512730.3 | |
Accession Version | NM_011603.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-09-22 | |
Organism | Mus musculus(house mouse) | |
Product | TATA box-binding protein-like protein 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BY275848.1, AK049975.1, BE650743.1 and BE995552.1. On Apr 8, 2009 this sequence version replaced NM_011603.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK078547.1, SRR1660819.166027.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849384, SAMN01164131 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTTTAATTA CAAATGTAGT CTGTGTTTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_035733.1 |
CDS | 376..936 |
Translation |

Target ORF information:
Target ORF information:
|
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ORF Insert Sequence:
1 | ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTTTAATTA CAAATGTAGT CTGTGTTTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu08452 | |
Clone ID Related Accession (Same CDS sequence) | XM_006512730.4 , NM_011603.5 , XM_006512730.3 | |
Accession Version | XM_006512730.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | TATA box-binding protein-like protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006512730.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTTTAATTA CAAATGTAGT CTGTGTTTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006512793.1 |
CDS | 506..1066 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTTTAATTA CAAATGTAGT CTGTGTTTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu08452 | |
Clone ID Related Accession (Same CDS sequence) | XM_006512730.4 , NM_011603.5 , XM_006512730.3 | |
Accession Version | XM_006512730.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP |
|
Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | TATA box-binding protein-like protein 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006512730.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTTTAATTA CAAATGTAGT CTGTGTTTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006512793.1 |
CDS | 928..1488 |
Translation |

Target ORF information:
Target ORF information:
|
![]() |

ORF Insert Sequence:
1 | ATGGATGCAG ACAGTGATGT TGCATTGGAC ATTTTAATTA CAAATGTAGT CTGTGTTTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
Myocardial VHL-HIF Signaling Controls an Embryonic Metabolic Switch Essential for Cardiac Maturation. |
![]() |
TBP-like protein (TLP) represses myogenesis via inhibition of the?myogenin promoter. |
![]() |
TRF2 is recruited to the pre-initiation complex as a testis-specific subunit of TFIIA/ALF to promote haploid cell gene expression. |
![]() |
TDRD5 is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis in mice. |
![]() |
Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. |