Gene Symbol | Phospho1 |
Entrez Gene ID | 237928 |
Full Name | phosphatase, orphan 1 |
Synonyms | D11Moh36,Phospo1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Phospho1 cDNA ORF clone
gRNAs
Gene Symbol | Phospho1 |
Entrez Gene ID | 237928 |
Full Name | phosphatase, orphan 1 |
Synonyms | D11Moh36,Phospo1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_153104.3 | NP_694744.1 | phosphoethanolamine/phosphocholine phosphatase |
Canis lupus familiaris (dog) | PHOSPHO1 | XP_005624681.1 |
Bos taurus (cattle) | PHOSPHO1 | NP_001180048.1 |
Mus musculus (house mouse) | Phospho1 | NP_694744.1 |
Oryza sativa (rice) | Os01g0720400 | NP_001044089.1 |
Arabidopsis thaliana (thale cress) | AT1G17710 | NP_173213.2 |
Arabidopsis thaliana (thale cress) | PS2 | NP_565052.1 |
Homo sapiens (human) | PHOSPHO1 | NP_001137276.1 |
Gallus gallus (chicken) | PHOSPHO1 | NP_990176.1 |
Xenopus tropicalis (tropical clawed frog) | phospho1 | XP_004918668.1 |
Pan troglodytes (chimpanzee) | PHOSPHO1 | XP_003953021.1 |
Rattus norvegicus (Norway rat) | Phospho1 | NP_001099303.1 |
Danio rerio (zebrafish) | phospho1 | NP_001003461.1 |
A distinctive patchy osteomalacia characterises Phospho1-deficient mice.
Boyde A, Staines KA, Javaheri B, Millan JL, Pitsillides AA, Farquharson C
Journal of anatomy231(2)298-308(2017 Aug)
Intravesicular Phosphatase PHOSPHO1 Function in Enamel Mineralization and Prism Formation.
Pandya M, Rosene L, Farquharson C, Mill?n JL, Diekwisch TGH
Frontiers in physiology8805(2017)
Role of PHOSPHO1 in Periodontal Development and Function.
Zweifler LE, Ao M, Yadav M, Kuss P, Narisawa S, Kolli TN, Wimer HF, Farquharson C, Somerman MJ, Mill?n JL, Foster BL
Journal of dental research95(7)742-51(2016 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
role in mineralization of alveolar bone and cellular cementum
Title: Role of PHOSPHO1 in Periodontal Development and Function.
These data support the involvement of phosphate transporter 1, hereafter referred to as Pi T-1, in the initiation of skeletal mineralization and provide compelling evidence that PHOSPHO1 function is involved in MV biogenesis
Title: Skeletal Mineralization Deficits and Impaired Biogenesis and Function of Chondrocyte-Derived Matrix Vesicles in Phospho1(-/-) and Phospho1/Pi t1 Double-Knockout Mice.
Deficiency in PHOSPHO1 exerts modifications in bone architecture that are transient and depend upon age.
Title: Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing.
ablation of the OPN gene, Spp1, leads to improvements in the skeletal phenotype in Phospho1(-/-) as they age
Title: Ablation of osteopontin improves the skeletal phenotype of phospho1(-/-) mice.
mineralization abnormalities of dentin; reduced overall mineralization with decreased matrix vesicle mineralization in the Phospho1(-/-) mice; almost complete absence of matrix vesicles in mice; further reduction in mineralization.
Title: Compounded PHOSPHO1/ALPL deficiencies reduce dentin mineralization.
The following Phospho1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Phospho1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu02298 | |
Clone ID Related Accession (Same CDS sequence) | NM_153104.3 | |
Accession Version | NM_153104.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-16 | |
Organism | Mus musculus(house mouse) | |
Product | phosphoethanolamine/phosphocholine phosphatase | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL593858.20. On Jul 29, 2009 this sequence version replaced NM_153104.2. Sequence Note: This RefSeq record was created from genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ457190.1, BY339347.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849375 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAGCGGGT GTTTTCCAGC TGTTGGACTA CGATGCCTAT CTAGGGACGG CAGGATGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_694744.1 |
CDS | 276..1079 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGAGCGGGT GTTTTCCAGC TGTTGGACTA CGATGCCTAT CTAGGGACGG CAGGATGGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
A distinctive patchy osteomalacia characterises Phospho1-deficient mice. |
Intravesicular Phosphatase PHOSPHO1 Function in Enamel Mineralization and Prism Formation. |
Role of PHOSPHO1 in Periodontal Development and Function. |