Gene Symbol | Bves |
Entrez Gene ID | 23828 |
Full Name | blood vessel epicardial substance |
Synonyms | Pop1,Popdc1,mBVES |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Bves cDNA ORF clone
Gene Symbol | Bves |
Entrez Gene ID | 23828 |
Full Name | blood vessel epicardial substance |
Synonyms | Pop1,Popdc1,mBVES |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
XM_006512736.3 | XP_006512799.1 | blood vessel epicardial substance isoform X1 |
XM_006512736.4 | XP_006512799.1 | blood vessel epicardial substance isoform X1 |
NM_024285.2 | NP_077247.1 | blood vessel epicardial substance |
XM_006512737.3 | XP_006512800.1 | blood vessel epicardial substance isoform X1 |
XM_006512737.2 | XP_006512800.1 | blood vessel epicardial substance isoform X1 |
NM_024285.3 | NP_077247.1 | blood vessel epicardial substance |
Mus musculus (house mouse) | Bves | NP_077247.1 |
Danio rerio (zebrafish) | bves | NP_001244093.1 |
Pan troglodytes (chimpanzee) | BVES | XP_527578.2 |
Canis lupus familiaris (dog) | BVES | XP_005627725.1 |
Rattus norvegicus (Norway rat) | Bves | NP_001071058.1 |
Xenopus tropicalis (tropical clawed frog) | bves | NP_001116888.1 |
Bos taurus (cattle) | BVES | XP_005210902.1 |
Homo sapiens (human) | BVES | NP_001186492.1 |
BVES | XP_001087344.1 | |
Gallus gallus (chicken) | BVES | NP_001001299.2 |
BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis.
Parang B, Kaz AM, Barrett CW, Short SP, Ning W, Keating CE, Mittal MK, Naik RD, Washington MK, Revetta FL, Smith JJ, Chen X, Wilson KT, Brand T, Bader DM, Tansey WP, Chen R, Brentnall TA, Grady WM, Williams CS
Gut66(5)852-862(2017 May)
High-throughput discovery of novel developmental phenotypes.
Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, , , , , , , , , MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bu?an M, Murray SA
Nature537(7621)508-514(2016 09)
BVES Regulates Intestinal Stem Cell Programs and Intestinal Crypt Viability after Radiation.
Reddy VK, Short SP, Barrett CW, Mittal MK, Keating CE, Thompson JJ, Harris EI, Revetta F, Bader DM, Brand T, Washington MK, Williams CS
Stem cells (Dayton, Ohio)34(6)1626-36(2016 06)
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Koscielny G, Yaikhom G, Iyer V, Meehan TF, Morgan H, Atienza-Herrero J, Blake A, Chen CK, Easty R, Di Fenza A, Fiegel T, Grifiths M, Horne A, Karp NA, Kurbatova N, Mason JC, Matthews P, Oakley DJ, Qazi A, Regnart J, Retha A, Santos LA, Sneddon DJ, Warren J, Westerberg H, Wilson RJ, Melvin DG, Smedley D, Brown SD, Flicek P, Skarnes WC, Mallon AM, Parkinson H
Nucleic acids research42(Database issue)D802-9(2014 Jan)
Popeye domain containing 1 (Popdc1/Bves) is a caveolae-associated protein involved in ischemia tolerance.
Alcalay Y, Hochhauser E, Kliminski V, Dick J, Zahalka MA, Parnes D, Schlesinger H, Abassi Z, Shainberg A, Schindler RF, Brand T, Kessler-Icekson G
PloS one8(9)e71100(2013)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
BVES plays a key role in maintaining the integrity of the colonic mucosa and protecting from inflammatory carcinogenesis. Additionally, these results provide the first in vivo and genetic evidence supporting the hypothesis that BVES regulates Wnt activity.
Title: BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis.
BVES is a key regulator of intestinal stem cell programs and mucosal homeostasis.
Title: BVES Regulates Intestinal Stem Cell Programs and Intestinal Crypt Viability after Radiation.
Bves and NDRG4 regulate directional epicardial cell migration through autocrine extracellular matrix deposition.
Title: Bves and NDRG4 regulate directional epicardial cell migration through autocrine extracellular matrix deposition.
The results indicate that Popdc1 is a caveolae-associated protein important for the preservation of caveolae structural and functional integrity and for heart protection.
Title: Popeye domain containing 1 (Popdc1/Bves) is a caveolae-associated protein involved in ischemia tolerance.
Popdc1 and Popdc2 proteins interact with the potassium channel TREK-1, which leads to increased cell surface expression and enhanced current density
Title: Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice.
The following Bves gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bves cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu18284 | |
Clone ID Related Accession (Same CDS sequence) | XM_006512736.3 , XM_006512736.4 , NM_024285.2 , XM_006512737.3 , XM_006512737.2 , NM_024285.3 | |
Accession Version | NM_024285.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1077bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-11-10 | |
Organism | Mus musculus(house mouse) | |
Product | blood vessel epicardial substance | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AC155715.24. On Nov 17, 2006 this sequence version replaced NM_024285.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF204174.1, BC132018.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGAATTCCA CGGAGTCCAT CCCGCTGGCA CAGTCAACTG TAGCAGGTTT TACATCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_077247.1 |
CDS | 132..1208 |
Translation |
Target ORF information:
Target ORF information:
|
NM_024285.2 |
1 | ATGAATTCCA CGGAGTCCAT CCCGCTGGCA CAGTCAACTG TAGCAGGTTT TACATCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu18284 | |
Clone ID Related Accession (Same CDS sequence) | XM_006512736.3 , XM_006512736.4 , NM_024285.2 , XM_006512737.3 , XM_006512737.2 , NM_024285.3 | |
Accession Version | NM_024285.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1077bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2020-01-01 | |
Organism | Mus musculus(house mouse) | |
Product | blood vessel epicardial substance | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC155715.24. On Feb 7, 2019 this sequence version replaced NM_024285.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF204174.1, SRR7345562.3101256.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849375, SAMN00849382 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAATTCCA CGGAGTCCAT CCCGCTGGCA CAGTCAACTG TAGCAGGTTT TACATCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_077247.1 |
CDS | 159..1235 |
Translation |
Target ORF information:
Target ORF information:
|
NM_024285.3 |
1 | ATGAATTCCA CGGAGTCCAT CCCGCTGGCA CAGTCAACTG TAGCAGGTTT TACATCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu18284 | |
Clone ID Related Accession (Same CDS sequence) | XM_006512736.3 , XM_006512736.4 , NM_024285.2 , XM_006512737.3 , XM_006512737.2 , NM_024285.3 | |
Accession Version | XM_006512736.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1077bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | blood vessel epicardial substance isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006512736.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAATTCCA CGGAGTCCAT CCCGCTGGCA CAGTCAACTG TAGCAGGTTT TACATCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006512799.1 |
CDS | 190..1266 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006512736.3 |
1 | ATGAATTCCA CGGAGTCCAT CCCGCTGGCA CAGTCAACTG TAGCAGGTTT TACATCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu18284 | |
Clone ID Related Accession (Same CDS sequence) | XM_006512736.3 , XM_006512736.4 , NM_024285.2 , XM_006512737.3 , XM_006512737.2 , NM_024285.3 | |
Accession Version | XM_006512737.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1077bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-21 | |
Organism | Mus musculus(house mouse) | |
Product | blood vessel epicardial substance isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 22, 2016 this sequence version replaced XM_006512737.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Mus musculus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAATTCCA CGGAGTCCAT CCCGCTGGCA CAGTCAACTG TAGCAGGTTT TACATCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006512800.1 |
CDS | 173..1249 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006512737.2 |
1 | ATGAATTCCA CGGAGTCCAT CCCGCTGGCA CAGTCAACTG TAGCAGGTTT TACATCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu18284 | |
Clone ID Related Accession (Same CDS sequence) | XM_006512736.3 , XM_006512736.4 , NM_024285.2 , XM_006512737.3 , XM_006512737.2 , NM_024285.3 | |
Accession Version | XM_006512736.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1077bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | blood vessel epicardial substance isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006512736.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAATTCCA CGGAGTCCAT CCCGCTGGCA CAGTCAACTG TAGCAGGTTT TACATCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006512799.1 |
CDS | 190..1266 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006512736.4 |
1 | ATGAATTCCA CGGAGTCCAT CCCGCTGGCA CAGTCAACTG TAGCAGGTTT TACATCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu18284 | |
Clone ID Related Accession (Same CDS sequence) | XM_006512736.3 , XM_006512736.4 , NM_024285.2 , XM_006512737.3 , XM_006512737.2 , NM_024285.3 | |
Accession Version | XM_006512737.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1077bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | blood vessel epicardial substance isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000076.6) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Aug 8, 2019 this sequence version replaced XM_006512737.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGAATTCCA CGGAGTCCAT CCCGCTGGCA CAGTCAACTG TAGCAGGTTT TACATCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006512800.1 |
CDS | 173..1249 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006512737.3 |
1 | ATGAATTCCA CGGAGTCCAT CCCGCTGGCA CAGTCAACTG TAGCAGGTTT TACATCTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis. |
High-throughput discovery of novel developmental phenotypes. |
BVES Regulates Intestinal Stem Cell Programs and Intestinal Crypt Viability after Radiation. |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
Popeye domain containing 1 (Popdc1/Bves) is a caveolae-associated protein involved in ischemia tolerance. |