Gene Symbol | Clca1 |
Entrez Gene ID | 23844 |
Full Name | chloride channel accessory 1 |
Synonyms | Clca2,Clca3,gob-5,gob5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
ORF » Species Summary » Mus musculus » Clca1 cDNA ORF clone
Gene Symbol | Clca1 |
Entrez Gene ID | 23844 |
Full Name | chloride channel accessory 1 |
Synonyms | Clca2,Clca3,gob-5,gob5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Mus musculus(house mouse) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_017474.2 | NP_059502.1 | calcium-activated chloride channel regulator 1 precursor |
XM_006501444.1 | XP_006501507.1 | calcium-activated chloride channel regulator 1 isoform X1 |
The Lymphatic Endothelial mCLCA1 Antibody Induces Proliferation and Growth of Lymph Node Lymphatic Sinuses.
Jordan-Williams KL, Ramanujam N, Farr AG, Ruddell A
PloS one11(5)e0156079(2016)
Integrin-Alpha IIb Identifies Murine Lymph Node Lymphatic Endothelial Cells Responsive to RANKL.
Cordeiro OG, Chypre M, Brouard N, Rauber S, Alloush F, Romera-Hernandez M, B?n?zech C, Li Z, Eckly A, Coles MC, Rot A, Yagita H, L?on C, Ludewig B, Cupedo T, Lanza F, Mueller CG
PloS one11(3)e0151848(2016)
The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice.
Erickson NA, Nystr?m EE, Mundhenk L, Arike L, Glauben R, Heimesaat MM, Fischer A, Bereswill S, Birchenough GM, Gruber AD, Johansson ME
PloS one10(7)e0131991(2015)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These findings demonstrate that 10.1.1 Ab rapidly and specifically induces proliferation and growth of Lymph Node lymphatic sinuses and stroma, suggesting a key role of mCLCA1 in coordinating Lymph Node remodeling during immune responses.
Title: The Lymphatic Endothelial mCLCA1 Antibody Induces Proliferation and Growth of Lymph Node Lymphatic Sinuses.
Clca1 is not required for mucus synthesis, structure and barrier function in the murine colon.
Title: The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice.
mCLCA3 appears to modulate leukocyte response via IL-17 and murine CXCL-8 homologs in acute Staphylococcus aureus pneumonia which is well in line with the proposed function of hCLCA1 as a signaling molecule acting on alveolar macrophages.
Title: mCLCA3 modulates IL-17 and CXCL-1 induction and leukocyte recruitment in murine Staphylococcus aureus pneumonia.
Findings suggest that increased expression of a single-gene, mCLCA3, could simulate an asthma attack, and its mechanism may involve mCLCA3 overexpression up-regulating IL-13 expression.
Title: Murine calcium-activated chloride channel family member 3 induces asthmatic airway inflammation independently of allergen exposure.
PA-LPS-induced MUC5AC and Clca3 expression is partly through Duox1
Title: P. aeruginosa lipopolysaccharide-induced MUC5AC and CLCA3 expression is partly through Duox1 in vitro and in vivo.
The following Clca1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Clca1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OMu31887 | |
Clone ID Related Accession (Same CDS sequence) | XM_006501444.1 | |
Accession Version | XM_006501444.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1878bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-07 | |
Organism | Mus musculus(house mouse) | |
Product | calcium-activated chloride channel regulator 1 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000069.6) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Mus musculus Annotation Release 108 Annotation Version :: 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGACAGCCC AGCCACCTGC ACCCACCTTC TCACTGCTGC AAATTGGACA AAGAATTGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_006501507.1 |
CDS | 605..2482 |
Translation |
Target ORF information:
Target ORF information:
|
XM_006501444.1 |
1 | ATGACAGCCC AGCCACCTGC ACCCACCTTC TCACTGCTGC AAATTGGACA AAGAATTGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OMu17804 | |
Clone ID Related Accession (Same CDS sequence) | NM_017474.2 | |
Accession Version | NM_017474.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2742bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-21 | |
Organism | Mus musculus(house mouse) | |
Product | calcium-activated chloride channel regulator 1 precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK033560.1 and AK008659.2. On Aug 13, 2009 this sequence version replaced NM_017474.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK033560.1, AB017156.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849377 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAATCTT TGAAGAGTCC TGTCTTCCTC TTGATCCTCC ACCTTCTGGA AGGAGTTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_059502.1 |
CDS | 32..2773 |
Translation |
Target ORF information:
Target ORF information:
|
NM_017474.2 |
1 | ATGGAATCTT TGAAGAGTCC TGTCTTCCTC TTGATCCTCC ACCTTCTGGA AGGAGTTCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The Lymphatic Endothelial mCLCA1 Antibody Induces Proliferation and Growth of Lymph Node Lymphatic Sinuses. |
Integrin-Alpha IIb Identifies Murine Lymph Node Lymphatic Endothelial Cells Responsive to RANKL. |
The Goblet Cell Protein Clca1 (Alias mClca3 or Gob-5) Is Not Required for Intestinal Mucus Synthesis, Structure and Barrier Function in Naive or DSS-Challenged Mice. |